Results 71 to 80 of about 56,530 (315)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy

Journal of experimental & clinical cancer research : CR
Previous studies by our group have shown that oxidative phosphorylation (OXPHOS) is the main pathway by which pancreatic cancer stem cells (CSCs) meet their energetic requirements; therefore, OXPHOS represents an Achille’s heel of these highly ...
S. Alcalá, Lara Villarino, L. Ruiz-Cañas, José R. Couceiro, Miguel Martínez-Calvo, A. Palencia-Campos, D. Navarro, P. Cabezas-Sáinz, Iker Rodriguez-Arabaolaza, A. Cordero-Barreal, L. Trilla-Fuertes, Juan A. Rubiolo, S. Batres-Ramos, M. Vallespinós, C. González-Páramos, Jéssica Rodríguez, A. Gámez-Pozo, J. A. F. Vara, S. Fernández, A. B. Berlinches, N. Moreno-Mata, A. Redondo, Alfredo Carrato, P. Hermann, Laura Sánchez, Susana Torrente, M. Fernández-Moreno, J. Mascareñas, B. Sainz   +28 more
semanticscholar   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Residual OXPHOS is required to drive primary and metastatic lung tumours in an orthotopic breast cancer model [PDF]

BackgroundFast adaptation of glycolytic and mitochondrial energy pathways to changes in the tumour microenvironment is a hallmark of cancer. Purely glycolytic ρ0 tumour cells do not form primary tumours unless they acquire healthy mitochondria from their
David Eccles, Michael Berridge, O'Sullivan, David, Alfonso Schmidt, Schmidt, Alfonso, Carole Grasso, Melanie McConnell, Danielle Lewthwaite, Neuzil, Jiri, David O’Sullivan, Georgia Carson, Andrew Wilson, Grasso, Carole, McConnell, Melanie, Carson, Georgia, Patries Herst, Herst, Patries, Wilson, Andrew, Lewthwaite, Danielle, Eccles, David, Jiri Neuzil, Berridge, Michael   +21 more
core   +1 more source

The deubiquitinase OTUB1 governs lung cancer cell fitness by modulating proteostasis of OXPHOS proteins [PDF]

, 2023
Aerobic glycolysis is a hallmark of cancer development, but this dogma has been challenged by reports showing a key role of oxidative phosphorylation (OXPHOS) in cancer cell survival.
Nivea Dias Amoedo, Amoedo, ND, Anna Sablina, Sheryazdanova, A, Rossignol, R, Rodrigue Rossignol, Sara Dufour, SHERYAZDANOVA, Aidana, Sablina, A, Aidana Sheryazdanova, Francis Impens, ROSSIGNOL, Rodrigue, Impens, Francis, Dufour, Sara, AMOEDO, Nivea Dias, SABLINA, Anna   +15 more
core   +1 more source

Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors

Zhongliu Fangzhi Yanjiu
Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism.
CHE Xin, HU Zhen, WANG Yonggang, LI Yaoping   +3 more
doaj   +1 more source

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

Cancer Research, 2021
These findings demonstrate a novel role for DLST in neuroblastoma aggression and identify the OXPHOS inhibitor IACS-010759 as a potential therapeutic strategy for this deadly disease.
Nicole M. Anderson, Xiaodan Qin, Jennifer M. Finan, Andrew Lam, Jacob Athoe, R. Missiaen, Nicolas Skuli, Annie Kennedy, Amandeep S. Saini, Ting Tao, Shizhen Zhu, Itzhak Nissim, A. Look, Guoliang Qing, M. Simon, H. Feng   +15 more
semanticscholar   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging [PDF]

, 2016
Defects in mitochondrial biogenesis and function are common in many neurodegenerative disorders, including Huntington’s disease (HD). We have previously shown that in yeast models of HD, enhancement of mitochondrial biogenesis through overexpression of ...
Yi Zhu, Chong Li, Zhu, Yi, Ocampo, Alejandro, Alejandro Ocampo, Andrea L. Ruetenik, Morgan L. McCarthy, R. Grace Zhai, Ruan, Kai, Li, Chong, Kai Ruan, Zhai, R Grace, Ruetenik, Andrea L, Antoni Barrientos, Barrientos, Antoni   +14 more
core   +1 more source

mtDNA copy number: molecular diagnostics and mitochondrial-nuclear crosstalk in frailty and ageing

Patologìâ
Quantitative assessment of mitochondrial DNA copy number is an emerging field of study in the diagnosis and evaluation of age-related pathology and frailty in the elderly, along with the assessment of other acute and chronic diseases that are often ...
C. G. Ward
doaj   +1 more source