Results 81 to 90 of about 46,956 (278)

Mitochondrial ataxia - Unravelling the puzzle

Annals of Movement Disorders
Primary mitochondrial diseases (PMDs) can be caused by a defect in any of the mitochondrial metabolic pathways, due to mitochondrial or nuclear DNA mutations, or occurring de novo. Ataxia is one of the most common presentations in mitochondrial disorders
Neha Pandita, Jacky Ganguly, Hrishikesh Kumar   +2 more
doaj   +1 more source

Analyzing the integrity of oxidative phosphorylation complexes in Drosophila flight muscles

STAR Protocols, 2021
Summary: Drosophila flight muscles are highly enriched with mitochondria and have emerged as a powerful genetic system for studying how oxidative phosphorylation (OXPHOS) complexes are assembled.
Anjaneyulu Murari, Edward Owusu-Ansah
doaj   +1 more source

Impaired OXPHOS Complex III in Breast Cancer

PLoS ONE, 2011
We measured the mitochondrial oxidative phosphorylation (mtOXPHOS) activities of all five complexes and determined the activity and gene expression in detail of the Complex III subunits in human breast cancer cell lines and primary tumors. Our analysis revealed dramatic differences in activity of complex III between normal and aggressive metastatic ...
Kjerstin M Owens, Mariola Kulawiec, Mohamad Mokhtar Desouki, Ayyasamy Vanniarajan, Keshav K Singh   +4 more
openaire   +4 more sources

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Attenuates of NAD+ impair BMSC osteogenesis and fracture repair through OXPHOS

Stem Cell Research & Therapy, 2022
Background Controlling the adipo-osteogenic lineage commitment of bone marrow mesenchymal stem cell (BMSC) in favor of osteogenesis is considered a promising approach for bone regeneration and repair.
Boer Li, Yu Shi, Mengyu Liu, Fanzi Wu, Xuchen Hu, Fanyuan Yu, Chenglin Wang, Ling Ye   +7 more
doaj   +1 more source

Spatial orchestration of mitochondrial translation and OXPHOS complex assembly. [PDF]

, 2018
Oxidative phosphorylation (OXPHOS) is vital for the regeneration of the vast majority of ATP in eukaryotic cells 1 . OXPHOS is carried out by large multi-subunit protein complexes in the cristae membranes, which are invaginations of the mitochondrial ...
Martin Ott, Stefan Jakobs, Jakobs, S., Riedel, D., Wenzel, Dirk, Stoldt, S., Kehrein, K., Kirsten Kehrein, Dietmar Riedel, Wenzel, D., Ott, M., Kehrein, Kirsten, Dirk Wenzel, Riedel, Dietmar, Ott, Martin, Stefan Stoldt, Stoldt, Stefan, Jakobs, Stefan   +17 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Copper-Induced Enhancement of Glioblastoma Tumorigenicity via Cytochrome C Oxidase

Antioxidants
Copper is an essential trace element, yet chronic copper exposure can lead to toxicity in humans, and high levels of copper have been found in the blood or tumors of patients with various forms of cancer and may affect cancer severity and response to ...
Claudia R. Oliva, Md Yousuf Ali, Susanne Flor, Corinne E. Griguer   +3 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Discovery of a Potent and Oral Available Complex I OXPHOS Inhibitor That Abrogates Tumor Growth and Circumvents MEKi Resistance

, 2023
Targeting oxidative phosphorylation (OXPHOS) has emerged as a promising therapeutic strategy for cancer therapy. Here, we discovered a 1H-1,2,3-triazole derivative HP661 as a highly potent and orally available OXPHOS inhibitor that effectively blocked ...
Yue Sun (197395), Tian Guan (8089241), Yangrui Peng (1845298), Xueli Zhang (383859), Xinting Xia (15390506), Xiufeng Pang (107423), Peng He (24579), Jia He (89641), Yihua Chen (107400), Mingyao Liu (38997), Juanjuan Feng (169164)   +10 more
core   +2 more sources