Results 21 to 30 of about 941,236 (333)
DNA-PKcs promotes sepsis-induced multiple organ failure by triggering mitochondrial dysfunction
Journal of Advanced Research, 2022 Introduction: Multiple organ failure is the commonest cause of death in septic patients. Objectives: This study was undertaken in an attempt to elucidate the functional importance of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) on ...
Rongjun Zou +11 more
doaj +1 more source
A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress. [PDF]
, 2018 BACKGROUND:Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood.
Aschbacher, Kirstin +7 more
core +1 more source
Royal Society Open Science, 2021 After initial detection of target archival DNA of a 116-year-old syntype specimen of the smooth lantern shark, Etmopterus pusillus, in a single-stranded DNA library, we shotgun-sequenced additional 9 million reads from this same DNA library.
Nicolas Straube +3 more
doaj +1 more source
A rapid and efficient method for enriching mitochondrial DNA from plants
Mitochondrial DNA. Part B. Resources, 2018 Current mitochondrial purification techniques are tedious and protracted due to their emphasis on recovering physiologically active mitochondria. However, for studies that are exclusively interested in isolating mitochondrial DNA (mtDNA) for applications
Mackenzie M. Strehle +2 more
doaj +1 more source
Cells, 2022 Mitochondria are well known as ‘the powerhouses of the cell’. Indeed, their major role is cellular energy production driven by both mitochondrial and nuclear DNA.
Amira Podolak +2 more
doaj +1 more source
Extensive Structural Variations Between Mitochondrial Genomes of CMS and Normal Peppers (Capsicum Annuum L.) Revealed by Complete Nucleotide Sequencing [PDF]
, 2014 Cytoplasmic male sterility (CMS) is an inability to produce functional pollen that is caused by mutation of the mitochondrial genome. Comparative analyses of mitochondrial genomes of lines with and without CMS in several species have revealed structural ...
Choi, Yoomi +4 more
core +2 more sources
Determination of Mitochondrial DNA Upon Drug Treatment
Bio-Protocol, 2015 Drug-induced mitochondrial injury can be caused by many different mechanisms including inhibition of mitochondrial DNA replication, transcription, translation, and altered protein function.
Michel Perron, Joy Feng
doaj +1 more source
Mitochondrial DNA-related Disorders
Bioscience Reports, 2007 Mitochondrial diseases are a group of disorders due to a mitochondrial respiratory chain deficiency. They may depend on mitochondrial genome (mtDNA-related disorders) as well as on a nuclear genome defect (nDNA-related disorders). mtDNA-related disorders encompass an increasing number of clinical pictures associated with more than 250 different ...
MANCUSO, MICHELANGELO +6 more
openaire +4 more sources
MitoNeoD:a mitochondria-targeted superoxide probe [PDF]
, 2017 Mitochondrial superoxide (O2⋅−) underlies much oxidative damage and redox signaling. Fluorescent probes can detect O2⋅−, but are of limited applicability in vivo, while in cells their usefulness is constrained by side reactions and DNA intercalation.
Anderson, Robert F. +19 more
core +5 more sources
Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae [PDF]
, 2019 Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments.
Balliano, Gianni +6 more
core +2 more sources