Results 271 to 280 of about 659,761 (294)

Mitochondrial function in melanoma

Archives of Biochemistry and Biophysics, 2014
Melanoma is the most lethal form of skin cancer and its incidence is rapidly rising. Breakthroughs in the understanding of the basic biology of melanoma in the past decade have yielded several new treatments, and advances continue to be made on a variety of fronts.
Nicholas, Theodosakis, Goran, Micevic, Daniel P, Kelly, Marcus, Bosenberg   +3 more
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Mitochondrial functions of polymelanosomes

Comparative Biochemistry and Physiology, 1967
Abstract 1. 1. Large cytoplasmic organelles containing melanin granules (polymelanosomes) were centrifugally isolated from the melanocytes of the Amphiuma tridactylum liver. 2. 2. These polymelanosomes have significant amounts of the following enzyme activities: succinic oxidase, cytochrome oxidase and monoamine oxidase. 3. 3.
M H, Van Woert, A, Nicholson, G C, Cotzias   +2 more
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Triptolide Alters Mitochondrial Functions

2007
Triptolide (TPL), a small molecule purified from the herb Tripterygium wilfordii, has potential clinical application for suppression of chronic autoimmune disorders and inhibition of tumor growth. However, its mechanism of action is largely unknown.
Ying, Su, Shanmin, Yang, Zhenyu, Xiao, Wei, Wang, Paul, Okunieff, Lurong, Zhang   +5 more
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Carnitine, mitochondrial function and therapy☆

Advanced Drug Delivery Reviews, 2009
Carnitine is important for cell function and survival primarily because of its involvement in the multiple equilibria between acylcarnitine and acyl-CoA esters established through the enzymatic activities of the family of carnitine acyltransferases. These have different acyl chain-length specificities and intracellular compartment distributions, and ...
Zammit VA, Ramsay RR, BONOMINI, Mario, Arduini Arduino   +3 more
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Mitochondrial functions and aging

Gene, 2002
In the filamentous ascomycete Podospora anserina mitochondria play a major role in lifespan control. Since the function of these organelles depends on a large number of individual components it is no surprise that a complex network of interacting branches of individual molecular pathways is involved in this process.
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Crosstalk between mitochondrial (dys)function and mitochondrial abundance

Journal of Cellular Physiology, 2012
AbstractA controlled regulation of mitochondrial mass through either the production (biogenesis) or the degradation (mitochondrial quality control) of the organelle represents a crucial step for proper mitochondrial and cell function. Key steps of mitochondrial biogenesis and quality control are overviewed, with an emphasis on the role of mitochondrial
Michel, Sébastien, Wanet, Anaïs, De Pauw, Aurélia, Rommelaere, Guillaume, Arnould, Thierry, Renard, Patricia   +5 more
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Mitochondrial functional complementation in mitochondrial DNA-based diseases

The International Journal of Biochemistry & Cell Biology, 2009
Mitochondria exist in networks that are continuously remodeled through fusion and fission. Why do individual mitochondria in living cells fuse and divide continuously? Protein machinery and molecular mechanism for the dynamic nature of mitochondria have been almost clarified.
Kazuto, Nakada, Akitsugu, Sato, Jun-ichi, Hayashi   +2 more
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Mitochondrial function, mitochondrial DNA and ageing: a reappraisal

Biogerontology, 2010
The impressive performance of the research in biology of mitochondrion has greatly improved our knowledge on the functions of this organelle and highlighted the influence its functioning has on numerous human phenotypes. In particular, many studies have focused on the involvement of mitochondrion function (and dysfunction) in human ageing. To date, the
PASSARINO, Giuseppe, ROSE, Giuseppina, BELLIZZI, Dina   +2 more
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Mitochondrial functions in stem cells

Current Opinion in Genetics & Development, 2016
Mitochondria fulfill multiple cellular functions beyond ATP production, including several functions that are specialized for distinct tissue types (thermogenesis, steroidogenesis). Recent evidence indicates that mitochondrial activities are regulated within cell lineages, and through incompletely understood mechanisms, are important for specification ...
Daciana H, Margineantu, David M, Hockenbery   +1 more
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Mitochondrial function in Babesia bovis

International Journal for Parasitology, 1992
A variety of anti-mitochondrial drugs that had previously been found to inhibit the growth of the malarial parasite Plasmodium falciparum were tested on Babesia bovis in vitro. Several of these drugs were found to be non-toxic towards B. bovis. However, those drugs that were found to inhibit babesial growth included compounds (shown in parentheses ...
M M, Gozar, W J, O'Sullivan, A S, Bagnara   +2 more
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