Results 91 to 100 of about 802,688 (257)

Mitochondrial Protein in the Nucleus [PDF]

CellBio, 2015
Other than the respiratory chain components, most mitochondrial proteins are synthesized in the cytosol and imported into the mitochondria. Many mitochondrial proteins therefore have at least a transient cytosolic appearance, and several have a dual mitochondrial-cytosol functional localization.
openaire   +2 more sources

Mitochondrial proteomics on human fibroblasts for identification of metabolic imbalance and cellular stress

Proteome Science, 2009
Background Mitochondrial proteins are central to various metabolic activities and are key regulators of apoptosis. Disturbance of mitochondrial proteins is therefore often associated with disease.
Bross Peter, Christensen Jane H, Pedersen Christina B, Stenbroen Vibeke, Vang Søren, Palmfeldt Johan, Gregersen Niels   +6 more
doaj   +1 more source

Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins [PDF]

, 2018
Objective—We explored mechanisms that alter mitochondrial structure and function in pulmonary endothelial cells (PEC) function after hyperoxia. Approach and Results—Mitochondrial structures of PECs exposed to hyperoxia or normoxia were visualized and ...
Audi, Said H., Beyer, Andreas M., Clough, Anne V., Durand, Matthew J., Ebben, Johnathan D., Hill, R. Blake, Jacobs, Elizabeth R., Ma, Cui, Medhora, Meetha, Terashvili, Maia, Toro, Laura Norwood, Zhu, Daling   +11 more
core   +1 more source

Mitochondrial import receptors for precursor proteins [PDF]

, 1991
The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria.
Attardi, Baker, Deshaies, Gillespie, Hartl, Hines, Horwich, Hwang, Kang, Kiebler, Klingenberg, Meyer, Murakami, Murakami, Murakami, Ono, Pain, Pfaller, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Riezman, Roise, Rosenberg, Schnell, Sheffield, So¨llner, So¨llner, Steger, Vestweber, Wickner   +34 more
core   +1 more source

Comprehensive sub-mitochondrial protein map of the parasitic protist Trypanosoma brucei defines critical features of organellar biology

Cell Reports, 2023
Summary: We have generated a high-confidence mitochondrial proteome (MitoTag) of the Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a mitochondrial localization had not been described before. We use the TrypTag dataset as
Jan Pyrih, Michael Hammond, Aline Alves, Samuel Dean, Jack Daniel Sunter, Richard John Wheeler, Keith Gull, Julius Lukeš   +7 more
doaj  

Protein sorting to mitochondria [PDF]

, 1990
According to the endosymbiont hypothesis, mitochondria have lost the autonomy of their prokaryotic ancestors. They have to import most of their proteins from the cytosol because the mitochondrial genome codes for only a small percentage of the ...
Hartl, Franz-Ulrich, Neupert, Walter
core   +1 more source

The mitochondrial uncoupling proteins.

Genome biology, 2002
The uncoupling proteins (UCPs) are transporters, present in the mitochondrial inner membrane, that mediate a regulated discharge of the proton gradient that is generated by the respiratory chain. This energy-dissipatory mechanism can serve functions such as thermogenesis, maintenance of the redox balance, or reduction in the production of reactive ...
Eduardo Rial, Mario García de Lacoba, Amalia Ledesma   +2 more
openaire   +3 more sources

Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis

Cell Reports, 2018
Summary: Mitochondria possess elaborate machineries for the import of proteins from the cytosol. Cytosolic factors like Hsp70 chaperones and their co-chaperones, the J-proteins, guide proteins to the mitochondrial surface.
Łukasz Opaliński, Jiyao Song, Chantal Priesnitz, Lena-Sophie Wenz, Silke Oeljeklaus, Bettina Warscheid, Nikolaus Pfanner, Thomas Becker   +7 more
doaj  

A Combined Mass Spectrometry and Data Integration Approach to Predict the Mitochondrial Poly(A) RNA Interacting Proteome

Frontiers in Cell and Developmental Biology, 2019
In order to synthesize the 13 oxidative phosphorylation proteins encoded by mammalian mtDNA, a large assortment of nuclear encoded proteins is required. These include mitoribosomal proteins and various RNA processing, modification and degradation enzymes.
Selma L. van Esveld, Şirin Cansız-Arda, Fenna Hensen, Robin van der Lee, Martijn A. Huynen, Johannes N. Spelbrink   +5 more
doaj   +1 more source

Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis [PDF]

, 2009
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial
A Degterev, A Müller, A Müller, AE Deghmane, Anke Harsman, B Shanmugavadivu, Dirk Günther, DM Walther, DR Voelker, E Gottlieb, E Gottlieb, Elke A. Dian-Lothrop, Eva Hauf, FJ Bauer, FJ Castora, G Kroemer, G Schatz, Hank Steven Seifert, I Guilvout, IE Gentle, Ines Herrmann, J Song, JE Chipuk, JF Weel, Joachim Rassow, K Hill, Katharina Ross, Krishnaraj Rajalingam, L Scorrano, LA Pon, LC Armstrong, LM Loew, M Meinecke, MC Wei, Michael Meinecke, MP Bos, N Bolender, N Pfanner, N Wiedemann, N Wiedemann, O Kepp, O Kepp, Oliver Kepp, P Massari, P Massari, P Mueller, R Voulhoux, RD Taylor, Richard Wagner, Robert Hurwitz, RP Zahedi, S Desagher, S Kutik, S Makino, SA Paschen, SA Paschen, T Krimmer, T Rudel, Thomas Rudel, V Kozjak, V Kozjak-Pavlovic, V Robert, Vera Kozjak-Pavlovic, Volker Brinkmann, W Neupert   +64 more
core   +4 more sources