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PLANT UNCOUPLING MITOCHONDRIAL PROTEINS
Annual Review of Plant Biology, 2006Uncoupling proteins (UCPs) are membrane proteins that mediate purine nucleotide-sensitive free fatty acid-activated H+ flux through the inner mitochondrial membrane. After the discovery of UCP in higher plants in 1995, it was acknowledged that these proteins are widely distributed in eukaryotic organisms.
Eugenio Vercesi, Anibal +5 more
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Mitochondrial biogenesis: Inhibitors of mitochondrial protein synthesis
Molecular and Cellular Biochemistry, 1977The effects of erythromycin, chloramphenicol, cycloheximide, pyrimethamine, chromate, cadmium, lead, nickel, 4-nitro-quinoline-1-oxide and thioacetamide on yeast and human cells were studied. Inhibition of the synthesis of mitochondrial proteins resulted in the loss of cytochromes as well as in morphological changes in the cellular membranes and ...
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Association of a Novel Mitochondrial Protein M19 with Mitochondrial Nucleoids
The Journal of Biochemistry, 2009We have identified a novel mitochondrial protein, termed M19, by proteomic analysis of mitochondrial membrane proteins from HeLa cells. M19 is highly conserved among vertebrates, and possesses no homologous domains with other known proteins. By northern and western blotting, mouse M19 was shown to be expressed in various tissues, and to be especially ...
Dongchon Kang +4 more
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Mitochondrial diseases caused by dysfunctional mitochondrial protein import
Biochemical Society Transactions, 2018Mitochondria are essential organelles which perform complex and varied functions within eukaryotic cells. Maintenance of mitochondrial health and functionality is thus a key cellular priority and relies on the organelle's extensive proteome. The mitochondrial proteome is largely encoded by nuclear genes, and mitochondrial proteins must be sorted to the
Diana Stojanovski +2 more
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Linking mitochondrial dynamics to mitochondrial protein quality control
Current Opinion in Genetics & Development, 2016Over the last decade, countless discoveries have been made that have expanded our knowledge of mitochondrial biology, and more often than not, these discoveries provided fascinating new insights into the etiology of human disease. For example, advances in mitochondrial genetics exposed the role of mitochondrial mutations in cancer progression, and the ...
Suraiya Haroon, Marc Vermulst
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Proteins of Mitochondrial Synthesis
Physiologia Plantarum, 1975AbstractProteins synthesized in vitro by mitochondria isolated from 48‐h germinating seeds of Vigna sinensis (L.) Savi and incubated in the presence of 14C‐labelled amino acids from Chlorella protein hydrolysate, have been found associated with nine products separable by acrylamide gel electrophoresis in the presence of sodium dodecyl sulphate ...
Prabir Bhattacharyya +6 more
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Chapter 8 Acetylation of Mitochondrial Proteins
2009Sirtuins (SIRT1-SIRT7) are a family of NAD(+)-dependent protein deacetylases that regulate cell survival, metabolism, and longevity. SIRT3 is localized to the mitochondria where it deacetylates several key metabolic enzymes: acetylcoenzyme A synthetase, glutamate dehydrogenase, and subunits of complex I and thereby regulates their enzymatic activity ...
Jing-Yi Huang +3 more
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Mitochondrial transport proteins of the brain
Journal of Neuroscience Research, 2007AbstractIn this study, cellular distribution and activity of glutamate and γ‐aminobutyric acid (GABA) transport as well as oxoglutarate transport across brain mitochondrial membranes were investigated. A goal was to establish cell‐type‐specific expression of key transporters and enzymes involved in neurotransmitter metabolism in order to estimate ...
Susan M. Hutson +5 more
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Mechanisms of mitochondrial protein import
Essays in Biochemistry, 2000Mitochondria import most of their proteins from the cytosol. Precursor forms of most matrix proteins as well as some IM and IMS proteins are synthesized on cytoplasmic ribosomes with N-terminal cleavable signal sequences. Many other mitochondrial proteins including IM carrier proteins contain internal targeting sequences.
Donna M. Gordon +2 more
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MITOCHONDRIAL PROTEIN DEGRADATION
1979Publisher Summary This chapter discusses mitochondrial protein degradation. Most proteins are made in the cytosol and migrate to the mitochondria; either the bulk of these proteins are degraded within the organelles or without. In the latter case, they must come out.
J. Cervera +3 more
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