Results 211 to 220 of about 600,085 (261)

Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein-Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1). [PDF]

Int J Mol Sci
Rueter J, Rimbach G, Bilke S, Tholey A, Huebbe P.   +4 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

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Glutathionylation of Mitochondrial Proteins

Antioxidants & Redox Signaling, 2005
Many proteins contain free thiols that can be modified by the reversible formation of mixed disulfides with low-molecular-weight thiols through a process called S-thiolation. As the majority of these modifications result from the interaction of protein thiols with the endogenous glutathione pool, protein glutathionylation is the predominant alteration.
Thomas R, Hurd, Nikola J, Costa, Christina C, Dahm, Samantha M, Beer, Stephanie E, Brown, Aleksandra, Filipovska, Michael P, Murphy   +6 more
openaire   +2 more sources

Mitochondrial ribosomal proteins: Candidate genes for mitochondrial disease [PDF]

Genetics in Medicine, 2004
Most of the energy requirement for cell growth, differentiation, and development is met by the mitochondria in the form of ATP produced by the process of oxidative phosphorylation. Human mitochondrial DNA encodes a total of 13 proteins, all of which are essential for oxidative phosphorylation.
Edward B Mougey, Nathan Fischel-Ghodsian, Fischel-Ghodsian Nathan   +2 more
exaly   +3 more sources

Mitochondrial protein import

Journal of Bioenergetics and Biomembranes, 1990
Most polypeptides of mitochondria are imported from the cytosol. Precursor proteins contain targeting and sorting information, often in the form of amino-terminal presequences. Precursors first bind to receptors in the outer membrane. Two putative import receptors have been identified: a 19-kilodalton protein (MOM19) in Neurospora mitochondria, and a ...
V, Geli, B, Glick
openaire   +2 more sources

Synthesis of Mitochondrial Proteins

1973
The recent discovery that the ubiquitous energy-transducing organelle of eukaryotic cells, the mitochondrion, contains its own DNA, distinct from that of the nucleus (for recent reviews, see 1-4), has generated intensive investigations in a number of related areas.
K, Dawidowicz, H R, Mahler
openaire   +2 more sources

Mitochondrial Myopathy with a Defect of Mitochondrial-Protein Transport

New England Journal of Medicine, 1990
The clinical and biochemical heterogeneity of the mitochondrial myopathies is now well established.1 , 2 Recent work has focused on identifying the molecular basis of these disorders and has demons...
A H, Schapira, J M, Cooper, J A, Morgan-Hughes, D N, Landon, J B, Clark   +4 more
openaire   +2 more sources

Biogenesis of Mitochondrial Proteins

2012
Depending on the organism, mitochondria consist approximately of 500-1,400 different proteins. By far most of these proteins are encoded by nuclear genes and synthesized on cytosolic ribosomes. Targeting signals direct these proteins into mitochondria and there to their respective subcompartment: the outer membrane, the intermembrane space (IMS), the ...
Johannes M, Herrmann, Sebastian, Longen, Daniel, Weckbecker, Matthieu, Depuydt   +3 more
openaire   +2 more sources

Mitochondrial Protein Import

1991
A dynamic picture of the mitochondrial protein import pathway is emerging, with conformational alteration a critical feature both preceding and following membrane translocation. The mediators of these steps of conformational alteration, as well as steps of recognition, translocation, and proteolytic cleavage, appear to be proteins. Using powerful tools
A L, Horwich, M, Cheng, A, West, R A, Pollock   +3 more
openaire   +2 more sources