Results 1 to 10 of about 195,005 (265)
Modelling Proteasome and Proteasome Regulator Activities [PDF]
Biomolecules, 2014 Proteasomes are key proteases involved in a variety of processes ranging from the clearance of damaged proteins to the presentation of antigens to CD8+ T-lymphocytes.
Juliane Liepe +4 more
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Frontiers in Cell and Developmental Biology, 2023 The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays critical roles in nervous system processes.
Kanisa Davidson, Andrew M. Pickering
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Cells, 2021 Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to hypothermia.
Nagat El Demerdash +6 more
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Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease
Molecules, 2020 The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
David J. Sherman, Jing Li
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Targeted Protein Degradation: Principles and Applications of the Proteasome
Cells, 2023 The proteasome is a multi-catalytic protease complex that is involved in protein quality control via three proteolytic activities (i.e., caspase-, trypsin-, and chymotrypsin-like activities).
Yosup Kim +4 more
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iScience, 2020 Summary: The proteasome is a therapeutic target in cancer, but resistance to proteasome inhibitors often develops owing to the induction of compensatory pathways.
Eiichi Hashimoto +7 more
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Wiggle and Shake: Managing and Exploiting Conformational Dynamics during Proteasome Biogenesis
Biomolecules, 2023 The 26S proteasome is the largest and most complicated protease known, and changes to proteasome assembly or function contribute to numerous human diseases.
Daniel Betancourt +2 more
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SPOP targets the immune transcription factor IRF1 for proteasomal degradation
eLife, 2023 Adaptation of the functional proteome is essential to counter pathogens during infection, yet precisely timed degradation of these response proteins after pathogen clearance is likewise key to preventing autoimmunity. Interferon regulatory factor 1 (IRF1)
Irene Schwartz +14 more
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Phosphatase UBLCP1 controls proteasome assembly [PDF]
Open Biology, 2017 Ubiquitin-like domain-containing C-terminal domain phosphatase 1 (UBLCP1), an FCP/SCP phosphatase family member, was identified as the first proteasome phosphatase.
Shuangwu Sun +7 more
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Role of amino acid metabolism in mitochondrial homeostasis
Frontiers in Cell and Developmental Biology, 2023 Mitochondria are central hubs for energy production, metabolism and cellular signal transduction in eukaryotic cells. Maintenance of mitochondrial homeostasis is important for cellular function and survival.
Qiaochu Li +2 more
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