Key features of the innate immune response is mediated by the immunoproteasome in microglia [PDF]
Scientific ReportsMicroglia are the resident immune cells of the central nervous system (CNS). We and others have shown that the inflammatory response of microglia is partially regulated by the immunoproteasome, an inducible form of the proteasome responsible for the ...
Salman Izadjoo +11 more
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Immunoproteasome subunits are novel signatures for predicting efficacy of immunotherapy in muscle invasive bladder cancer [PDF]
Journal of Translational MedicineBackground How to select muscle-invasive bladder cancer (MIBC) patients who are sensitive to immunotherapy is an unmet medical need. This study aimed to explore the role of immunoproteasome subunits as a novel signature for predicting efficacy of ...
XinJian Wang +10 more
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Immunoproteasome Inhibition Impairs Differentiation but Not Survival of T Helper 17 Cells [PDF]
CellsAutoimmune and inflammatory diseases are characterized by aberrant immune responses. The immunoproteasome was proposed as a target for such Th cell-mediated diseases due to its role in the activation, differentiation and function of T cells.
Franziska Oliveri +3 more
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The role of the immunoproteasome in cardiovascular disease
Pharmacological ResearchThe ubiquitinproteasome system (UPS) is the main mechanism responsible for the intracellular degradation of misfolded or damaged proteins. Under inflammatory conditions, the immunoproteasome, an isoform of the proteasome, can be induced, enhancing the ...
Yifei Nie +6 more
doaj +4 more sources
Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors [PDF]
Cells, 2022 Targeting proteasome with proteasome inhibitors (PIs) is an approved treatment strategy in multiple myeloma that has also been explored pre-clinically and clinically in other hematological malignancies.
Andrej Besse +6 more
doaj +4 more sources
The dichotomous role of immunoproteasome in cancer: Friend or foe?
Acta Pharmaceutica Sinica B, 2023 Immunoproteasome is a variant of proteasome with structural differences in 20S subunits optimizing them for the production of antigenic peptides with higher binding affinity to major histocompatibility complex (MHC)-I molecules.
Ji Cao
exaly +3 more sources
Current landscape of the immunoproteasome: implications for disease and therapy. [PDF]
Cell Death DiscovThe immunoproteasome, an inflammation-induced proteasome variant, coordinates proteostasis and adaptive immunity by replacing constitutive subunits (β1, β2, β5) with inducible counterparts (β1i, β2i, β5i).
Zou Z +11 more
europepmc +2 more sources
Emerging role of the immunoproteasome as a druggable target in lung inflammatory diseases [PDF]
Respiratory ResearchThe ubiquitin-proteasome system is the primary system that mediates protein turn over through proteolytic activities in the 20S proteasome that catalyzes peptide hydrolysis.
Jiaxing Miao +3 more
doaj +2 more sources
Immunoproteasome Inhibition Modulates Microglial Polarization to Facilitate Anti-Inflammatory Responses and Hematoma Resolution After Intracerebral Hemorrhage [PDF]
CellsIntracerebral hemorrhage induces severe secondary brain injury characterized by excessive neuroinflammation and inefficient hematoma clearance, processes largely governed by microglial polarization and phagocytic activity.
Wei-Fen Hu +9 more
doaj +2 more sources
On the Role of the Immunoproteasome in Protein Homeostasis [PDF]
Cells, 2021 Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
doaj +4 more sources