Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. [PDF]
PLoS ONE, 2016 The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome.
Haiming M Liu +3 more
doaj +24 more sources
The immunoproteasome and viral infection: a complex regulator of inflammation [PDF]
Frontiers in Microbiology, 2015 During viral infection, proper regulation of immune responses is necessary to ensure successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role in the generation of antigenic peptides for presentation on MHC class I ...
Jason B Weinberg, Mary McCarthy
exaly +4 more sources
The dichotomous role of immunoproteasome in cancer: Friend or foe?
Acta Pharmaceutica Sinica B, 2023 Immunoproteasome is a variant of proteasome with structural differences in 20S subunits optimizing them for the production of antigenic peptides with higher binding affinity to major histocompatibility complex (MHC)-I molecules.
Ji Cao
exaly +3 more sources
Key features of the innate immune response is mediated by the immunoproteasome in microglia [PDF]
Scientific ReportsMicroglia are the resident immune cells of the central nervous system (CNS). We and others have shown that the inflammatory response of microglia is partially regulated by the immunoproteasome, an inducible form of the proteasome responsible for the ...
Salman Izadjoo +11 more
doaj +2 more sources
Emerging role of the immunoproteasome as a druggable target in lung inflammatory diseases [PDF]
Respiratory ResearchThe ubiquitin-proteasome system is the primary system that mediates protein turn over through proteolytic activities in the 20S proteasome that catalyzes peptide hydrolysis.
Jiaxing Miao +3 more
doaj +2 more sources
New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells [PDF]
Journal of Immunology Research, 2015 The immunoproteasome is a highly efficient proteolytic machinery derived from the constitutive proteasome and is abundantly expressed in immune cells.
Hiroaki Kimura +3 more
doaj +2 more sources
Downhill exercise alters immunoproteasome content in mouse skeletal muscle [PDF]
, 2017 Content of the immunoproteasome, the inducible form of the standard proteasome, increases in atrophic muscle suggesting it may be associated with skeletal muscle remodeling.
Baumann, Cory W. +3 more
core +3 more sources
Immunoproteasome deficiency protects in the retina after optic nerve crush. [PDF]
PLoS ONE, 2015 The immunoproteasome is upregulated by disease, oxidative stress, and inflammatory cytokines, suggesting an expanded role for the immunoproteasome in stress signaling that goes beyond its canonical role in generating peptides for antigen presentation ...
Nathan J Schuld +9 more
doaj +3 more sources
Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation [PDF]
Journal of NeuroinflammationObjective Obesity represents a significant global health challenge characterized by chronic low-grade inflammation and metabolic dysregulation. The hypothalamus, a key regulator of energy homeostasis, is particularly susceptible to obesity’s deleterious ...
Nicolás Albornoz +12 more
doaj +2 more sources
The role of immunoproteasome in diabetes and diabetes-related complications [PDF]
Genes and DiseasesThe immunoproteasome represents a specialized isoform of the proteasome that is integral to the processes of antigen presentation and protein degradation.
Mengwen Wang +4 more
doaj +2 more sources