Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors [PDF]
Cells, 2022 Targeting proteasome with proteasome inhibitors (PIs) is an approved treatment strategy in multiple myeloma that has also been explored pre-clinically and clinically in other hematological malignancies.
Andrej Besse +6 more
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The immunoproteasome and viral infection: a complex regulator of inflammation
Frontiers in Microbiology, 2015 During viral infection, proper regulation of immune responses is necessary to ensure successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role in the generation of antigenic peptides for presentation on MHC class I ...
Jason Weinberg
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Immunoproteasome Inhibition Impairs Differentiation but Not Survival of T Helper 17 Cells [PDF]
CellsAutoimmune and inflammatory diseases are characterized by aberrant immune responses. The immunoproteasome was proposed as a target for such Th cell-mediated diseases due to its role in the activation, differentiation and function of T cells.
Franziska Oliveri +3 more
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Immunoproteasome deficiency protects in the retina after optic nerve crush. [PDF]
PLoS ONE, 2015 The immunoproteasome is upregulated by disease, oxidative stress, and inflammatory cytokines, suggesting an expanded role for the immunoproteasome in stress signaling that goes beyond its canonical role in generating peptides for antigen presentation ...
Nathan J Schuld +9 more
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The dichotomous role of immunoproteasome in cancer: Friend or foe?
Acta Pharmaceutica Sinica B, 2023 Immunoproteasome is a variant of proteasome with structural differences in 20S subunits optimizing them for the production of antigenic peptides with higher binding affinity to major histocompatibility complex (MHC)-I molecules.
Ji Cao, Haiying Zhu, Boya Chen
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Key features of the innate immune response is mediated by the immunoproteasome in microglia [PDF]
Scientific ReportsMicroglia are the resident immune cells of the central nervous system (CNS). We and others have shown that the inflammatory response of microglia is partially regulated by the immunoproteasome, an inducible form of the proteasome responsible for the ...
Salman Izadjoo +11 more
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Emerging role of the immunoproteasome as a druggable target in lung inflammatory diseases [PDF]
Respiratory ResearchThe ubiquitin-proteasome system is the primary system that mediates protein turn over through proteolytic activities in the 20S proteasome that catalyzes peptide hydrolysis.
Jiaxing Miao +3 more
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Immunoproteasome Inhibition Modulates Microglial Polarization to Facilitate Anti-Inflammatory Responses and Hematoma Resolution After Intracerebral Hemorrhage [PDF]
CellsIntracerebral hemorrhage induces severe secondary brain injury characterized by excessive neuroinflammation and inefficient hematoma clearance, processes largely governed by microglial polarization and phagocytic activity.
Wei-Fen Hu +9 more
doaj +2 more sources
The role of immunoproteasome in diabetes and diabetes-related complications [PDF]
Genes and DiseasesThe immunoproteasome represents a specialized isoform of the proteasome that is integral to the processes of antigen presentation and protein degradation.
Mengwen Wang +4 more
doaj +2 more sources
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis
EMBO Molecular Medicine, 2014 Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function
Marcus Groettrup +2 more
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