Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors [PDF]
Cells, 2022 Targeting proteasome with proteasome inhibitors (PIs) is an approved treatment strategy in multiple myeloma that has also been explored pre-clinically and clinically in other hematological malignancies.
Andrej Besse +6 more
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The dichotomous role of immunoproteasome in cancer: Friend or foe?
Acta Pharmaceutica Sinica B, 2023 Immunoproteasome is a variant of proteasome with structural differences in 20S subunits optimizing them for the production of antigenic peptides with higher binding affinity to major histocompatibility complex (MHC)-I molecules.
Ji Cao, Haiying Zhu
exaly +3 more sources
Key features of the innate immune response is mediated by the immunoproteasome in microglia [PDF]
Scientific ReportsMicroglia are the resident immune cells of the central nervous system (CNS). We and others have shown that the inflammatory response of microglia is partially regulated by the immunoproteasome, an inducible form of the proteasome responsible for the ...
Salman Izadjoo +11 more
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Emerging role of the immunoproteasome as a druggable target in lung inflammatory diseases [PDF]
Respiratory ResearchThe ubiquitin-proteasome system is the primary system that mediates protein turn over through proteolytic activities in the 20S proteasome that catalyzes peptide hydrolysis.
Jiaxing Miao +3 more
doaj +2 more sources
Inhibition of the immunoproteasome modulates innate immunity to ameliorate muscle pathology of dysferlin-deficient BlAJ mice [PDF]
Cell Death and Disease, 2022 Muscle repair in dysferlinopathies is defective. Although macrophage (Mø)-rich infiltrates are prominent in damaged skeletal muscles of patients with dysferlinopathy, the contribution of the immune system to the disease pathology remains to be fully ...
A. Farini +8 more
doaj +2 more sources
Immunoproteasome Inhibition Modulates Microglial Polarization to Facilitate Anti-Inflammatory Responses and Hematoma Resolution After Intracerebral Hemorrhage [PDF]
CellsIntracerebral hemorrhage induces severe secondary brain injury characterized by excessive neuroinflammation and inefficient hematoma clearance, processes largely governed by microglial polarization and phagocytic activity.
Wei-Fen Hu +9 more
doaj +2 more sources
The role of immunoproteasome in diabetes and diabetes-related complications [PDF]
Genes and DiseasesThe immunoproteasome represents a specialized isoform of the proteasome that is integral to the processes of antigen presentation and protein degradation.
Mengwen Wang +4 more
doaj +2 more sources
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis
EMBO Molecular Medicine, 2014 Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function
Marcus Gröttrup +2 more
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Immunoproteasome deficiency protects in the retina after optic nerve crush. [PDF]
PLoS ONE, 2015 The immunoproteasome is upregulated by disease, oxidative stress, and inflammatory cytokines, suggesting an expanded role for the immunoproteasome in stress signaling that goes beyond its canonical role in generating peptides for antigen presentation ...
Nathan J Schuld +9 more
doaj +1 more source
Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. [PDF]
PLoS ONE, 2016 The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome.
Haiming M Liu +3 more
doaj +1 more source