LMP7 as a Target for Coronavirus Therapy: Inhibition by Ixazomib and Interaction with SARS-CoV-2 Proteins Nsp13 and Nsp16 [PDF]
PathogensThe emergence of human coronaviruses has led to three epidemics or pandemics in the last two decades, collectively causing millions of deaths and thus highlighting a long-term need to identify new antiviral drug targets and develop antiviral therapeutics.
Yi Ru +12 more
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Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection
Scientific Reports, 2022 Immunoproteasomes (IP) serve as an important modulator of immune responses to pathogens and other pathological factors. LMP7/β5i, one of the IP subunits, plays a critical role in autoimmune diseases by downregulating inflammation.
Kris Genelyn Dimasuay +7 more
doaj +3 more sources
Immunoproteasome Inhibition Modulates Microglial Polarization to Facilitate Anti-Inflammatory Responses and Hematoma Resolution After Intracerebral Hemorrhage [PDF]
CellsIntracerebral hemorrhage induces severe secondary brain injury characterized by excessive neuroinflammation and inefficient hematoma clearance, processes largely governed by microglial polarization and phagocytic activity.
Wei-Fen Hu +9 more
doaj +2 more sources
Immunoproteasome inhibition triggers protein stress and apoptosis in cells of B cell lineage without impairing vaccination-induced antibody responses [PDF]
Cell Death DiscoveryThe immunoproteasome (IP) is a specialized form of the 26S proteasome, in which the catalytic subunits β1c, β2c, and β5c of the standard proteasome are replaced by LMP2, MECL-1, and LMP7.
Dennis Mink +7 more
doaj +2 more sources
Peripheral blood mononuclear cell low molecular mass protein 7 in acute ischemic stroke: vertical change from admission to discharge and correlation with disability, stroke recurrence, and death [PDF]
Frontiers in ImmunologyObjectiveLow molecular mass protein 7 (LMP7) aggravates abnormal T cell differentiation and atherosclerosis, but its clinical role in acute ischemic stroke (AIS) is still unclear.
Lujia Hou, Yanlei Zhang
doaj +2 more sources
Degradation of IL-4Ralpha by Immunoproteasome: implication in airway type 2 inflammation and hyperresponsiveness [PDF]
Frontiers in ImmunologyIntroductionImmunoproteasome (IP) is induced by pro-inflammatory stimuli such as interferon gamma to regulate inflammation and immunity. Asthma patients with airway type 2 high inflammation (e.g., IL-13) demonstrate more eosinophils and airway ...
Niccolette Schaunaman +3 more
doaj +2 more sources
Emerging role of the immunoproteasome as a druggable target in lung inflammatory diseases [PDF]
Respiratory ResearchThe ubiquitin-proteasome system is the primary system that mediates protein turn over through proteolytic activities in the 20S proteasome that catalyzes peptide hydrolysis.
Jiaxing Miao +3 more
doaj +2 more sources
Three-Dimensional Tumor Spheroids Reveal B7-H3 CAR T Cell Infiltration Dynamics and Microenvironment-Induced Functional Reprogramming in Solid Tumors [PDF]
CellsChimeric antigen receptor (CAR) T cell therapy has demonstrated clinical success in hematologic malignancies but has limited efficacy in solid tumors due to tumor microenvironment (TME) barriers that impede CAR T cell recognition, infiltration, and ...
Feng Chen +5 more
doaj +2 more sources
Evidence of Immunoproteasome Expression Onset in the Formative State of Pluripotency in Mouse Cells [PDF]
CellsEmbryonic stem cells (ESCs) are remarkable for the high activity level of ubiquitin–proteasome system—the molecular machinery of protein degradation in the cell.
Daria Kriger +6 more
doaj +2 more sources
LMP7-Specific Inhibitor M3258 Modulates the Tumor Microenvironment of Triple-Negative Breast Cancer and Inflammatory Breast Cancer [PDF]
CancersMichael Sanderson +2 more
exaly +2 more sources