Results 1 to 10 of about 1,750 (109)

LMP7 as a Target for Coronavirus Therapy: Inhibition by Ixazomib and Interaction with SARS-CoV-2 Proteins Nsp13 and Nsp16 [PDF]

Pathogens
The emergence of human coronaviruses has led to three epidemics or pandemics in the last two decades, collectively causing millions of deaths and thus highlighting a long-term need to identify new antiviral drug targets and develop antiviral therapeutics.
Yi Ru, Yue Ma-Lauer, Chengyu Xiang, Pengyuan Li, Brigitte von Brunn, Anja Richter, Christian Drosten, Andreas Pichlmair, Susanne Pfefferle, Markus Klein, Robert D. Damoiseaux, Ulrich A. K. Betz, Albrecht von Brunn   +12 more
doaj   +2 more sources

Immunoproteasome Inhibition Modulates Microglial Polarization to Facilitate Anti-Inflammatory Responses and Hematoma Resolution After Intracerebral Hemorrhage [PDF]

Cells
Intracerebral hemorrhage induces severe secondary brain injury characterized by excessive neuroinflammation and inefficient hematoma clearance, processes largely governed by microglial polarization and phagocytic activity.
Wei-Fen Hu, Chien-Hui Lee, Hsin-Yi Huang, Cheng-Yoong Pang, Yi-Feng Wu, Tsung-Jen Lin, Peter Bor-Chian Lin, Sheng-Tzung Tsai, Chia-Ho Lin, Hock-Kean Liew   +9 more
doaj   +2 more sources

Immunoproteasome inhibition triggers protein stress and apoptosis in cells of B cell lineage without impairing vaccination-induced antibody responses [PDF]

Cell Death Discovery
The immunoproteasome (IP) is a specialized form of the 26S proteasome, in which the catalytic subunits β1c, β2c, and β5c of the standard proteasome are replaced by LMP2, MECL-1, and LMP7.
Dennis Mink, Franziska Oliveri, Julia Otto, Nazlim Kutsi, Carolina Gonzalez Siebold, Tony Muchamuel, Jun Li, Michael Basler   +7 more
doaj   +2 more sources

Peripheral blood mononuclear cell low molecular mass protein 7 in acute ischemic stroke: vertical change from admission to discharge and correlation with disability, stroke recurrence, and death [PDF]

Frontiers in Immunology
ObjectiveLow molecular mass protein 7 (LMP7) aggravates abnormal T cell differentiation and atherosclerosis, but its clinical role in acute ischemic stroke (AIS) is still unclear.
Lujia Hou, Yanlei Zhang
doaj   +2 more sources

Degradation of IL-4Ralpha by Immunoproteasome: implication in airway type 2 inflammation and hyperresponsiveness [PDF]

Frontiers in Immunology
IntroductionImmunoproteasome (IP) is induced by pro-inflammatory stimuli such as interferon gamma to regulate inflammation and immunity. Asthma patients with airway type 2 high inflammation (e.g., IL-13) demonstrate more eosinophils and airway ...
Niccolette Schaunaman, Diana Cervantes, Deborah A. Ferrington, Hong Wei Chu   +3 more
doaj   +2 more sources

Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia

Frontiers in Immunology, 2021
The immunoproteasome, a special isoform of the 20S proteasome, is expressed when the cells receive an inflammatory signal. Immunoproteasome inhibition proved efficacy in the treatment of autoimmune diseases.
Lu Liu, Miao Xu, Jun Peng
exaly   +3 more sources

Emerging role of the immunoproteasome as a druggable target in lung inflammatory diseases [PDF]

Respiratory Research
The ubiquitin-proteasome system is the primary system that mediates protein turn over through proteolytic activities in the 20S proteasome that catalyzes peptide hydrolysis.
Jiaxing Miao, Nargis Shaheen, Yutong Zhao, Jing Zhao   +3 more
doaj   +2 more sources

Three-Dimensional Tumor Spheroids Reveal B7-H3 CAR T Cell Infiltration Dynamics and Microenvironment-Induced Functional Reprogramming in Solid Tumors [PDF]

Cells
Chimeric antigen receptor (CAR) T cell therapy has demonstrated clinical success in hematologic malignancies but has limited efficacy in solid tumors due to tumor microenvironment (TME) barriers that impede CAR T cell recognition, infiltration, and ...
Feng Chen, Ke Ning, Yuanyuan Xie, Xiaoyan Yang, Ling Yu, Xinhui Wang   +5 more
doaj   +2 more sources

Evidence of Immunoproteasome Expression Onset in the Formative State of Pluripotency in Mouse Cells [PDF]

Cells
Embryonic stem cells (ESCs) are remarkable for the high activity level of ubiquitin–proteasome system—the molecular machinery of protein degradation in the cell.
Daria Kriger, Uliana I. Podenkova, Evgeny I. Bakhmet, Evgenii Potapenko, Elena Ivanova, Alexey N. Tomilin, Anna S. Tsimokha   +6 more
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Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema Via Activating NRF1/2‐P62 Axis and Suppressing IRF4 Transcription [PDF]

Advanced Science
Chronic obstructive pulmonary disease (COPD) stands as the prevailing chronic airway ailment, characterized by chronic bronchitis and emphysema. Current medications fall short in treatment of these diseases, underscoring the urgent need for effective ...
Bingxin Guo, Xing Shi, Qiong Jiang, Yuanwei Pan, Yuqiong Yang, Yuanyuan Liu, Shuyu Chen, Wenjiao Zhu, Laibin Ren, Ruifang Liang, Xue Chen, Haizhao Xu, Laiyou Wei, Yongjian Lin, Jinyong Wang, Chen Qiu, Haibo Zhou, Lang Rao, Lingwei Wang, Rongchang Chen, Shanze Chen   +20 more
doaj   +2 more sources