Results 21 to 30 of about 1,819 (163)
The proteasome system in infection: impact of β5 and LMP7 on composition, maturation and quantity of active proteasome complexes. [PDF]
PLoS ONE, 2012 Proteasomes are the major enzyme complexes for non-lysosomal protein degradation in eukaryotic cells. Mammals express two sets of catalytic subunits: the constitutive subunits β1, β2 and β5 and the immunosubunits LMP2 (β1i), MECL-1 (β2i) and LMP7 (β5i ...
Thorsten Joeris +7 more
doaj +1 more source
Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders [PDF]
Scientific Reports, 2015 AbstractInflammation plays an important role in the development of obesity and metabolic disorders; however, it has not been fully understood how inflammation occurs and is regulated in their pathogenesis. Low-molecular mass protein-7 (LMP7) is a proteolytic subunit of the immunoproteasome that shapes the repertoire of antigenic peptides on major ...
Hiroaki Kimura +14 more
openaire +2 more sources
Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis
Life, 2021 Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk ...
Wanda Niepiekło-Miniewska +6 more
doaj +1 more source
Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity [PDF]
The EMBO Reports, 2018 Cells of hematopoietic origin express high levels of the immunoproteasome, a cytokine-inducible proteasome variant comprising the proteolytic subunits LMP2 (β1i), MECL-1 (β2i), and LMP7 (β5i). Targeting the immunoproteasome in pre-clinical models of autoimmune diseases with the epoxyketone inhibitor ONX 0914 has proven to be effective.
Michael Basler +11 more
openaire +5 more sources
Frontiers in Oncology, 2020 ObjectiveThe Wnt/ß-catenin pathway plays an important role in pathogenesis of variety cancers. Most studies on changes in WNT/β-catenin pathway in renal cell carcinoma (RCC) apply only to clear cell RCC, while there are no comparative assessments of this
Żaneta Piotrowska +4 more
doaj +1 more source
Post-transcriptional and epigenetic regulation of antigen processing machinery (APM) components and HLA-I in cervical cancers from Uighur women. [PDF]
PLoS ONE, 2012 Normal function of human leukocyte antigen class I (HLA-I) and antigen processing machinery (APM) proteins is required for T cell-mediated anti-tumor or antiviral immunity, whereas the tumor survival indicates a failure of the host in immune surveillance
Ayshamgul Hasim +7 more
doaj +1 more source
Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV‐induced meningitis [PDF]
European Journal of Immunology, 2015 In addition to antigen processing, immunoproteasomes were recently shown to exert functions influencing cytokine production by monocytes and T cells, T‐helper cell differentiation, and T‐cell survival. Moreover, selective inhibition of the immunoproteasome subunit LMP7 ameliorated symptoms of autoimmune diseases including CD4+ T‐cell mediated EAE.
Mundt Sarah +4 more
openaire +4 more sources
Histone deacetylase‐based dual targeted inhibition in multiple myeloma
Medicinal Research Reviews, Volume 43, Issue 6, Page 2177-2236, November 2023., 2023 Abstract Despite enormous advances in terms of therapeutic strategies, multiple myeloma (MM) still remains an incurable disease with MM patients often becoming resistant to standard treatments. To date, multiple combined and targeted therapies have proven to be more beneficial compared to monotherapy approaches, leading to a decrease in drug resistance
Angelica Ferro +3 more
wiley +1 more source
High glucose leads to redistribution of the proteasomal system
BioFactors, Volume 49, Issue 3, Page 636-645, May/June 2023., 2023 The original confocal microscopic image (RGB, left) was split into its three channels “red,” “green,” and “blue.” The single channels were evaluated separately in an automated process using a modified ImageJ macro. Abstract The impact of high glucose on the cellular redox state, causing both induction of antioxidative systems and also enhanced protein ...
Tilman Grune +2 more
wiley +1 more source
Translational Oncology, 2015 OBJECTIVES: Patients with human papillomavirus (HPV)–positive tonsillar squamous cell carcinoma (TSCC) and base of tongue squamous cell carcinoma (BOTSCC) have a better clinical outcome than those with corresponding HPV-negative tumors.
Nikolaos Tertipis +6 more
doaj +1 more source