Results 21 to 30 of about 2,423 (198)

Characterization of the immunproteasome subunits LMP2 and LMP7 in the mouse brain

, 2018
Die hier verfasste Dissertation beinhaltet eine Lokalisationsstudie sowie eine funktionelle Charakterisierung der katalytischen Untereinheiten LMP2 und LMP7 des Immunoproteasomes (IPs) im Gehirn der Maus.
Säring, Paula
core   +3 more sources

The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis [PDF]

Frontiers in Immunology, 2021
Cell survival and function critically relies on the fine-tuned balance of protein synthesis and degradation. In the steady state, the standard proteasome is sufficient to maintain this proteostasis.
Timothy French, Nicole Israel, Nicole Israel, Henning Peter Düsedau, Anne Tersteegen, Johannes Steffen, Clemens Cammann, Clemens Cammann, Eylin Topfstedt, Daniela Dieterich, Daniela Dieterich, Thomas Schüler, Ulrike Seifert, Ulrike Seifert, Ildiko Rita Dunay, Ildiko Rita Dunay   +15 more
doaj   +3 more sources

Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

EBioMedicine, 2018
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders.
Scott Ugras, Malcolm J. Daniels, Hossein Fazelinia, Neal S. Gould, Anastasia K. Yocum, Kelvin C. Luk, Esteban Luna, Hua Ding, Chris McKennan, Steven Seeholzer, Dan Martinez, Perry Evans, Daniel Brown, John E. Duda, Harry Ischiropoulos   +14 more
doaj   +2 more sources

Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.

PLoS Pathogens, 2011
Proteasomes recognize and degrade poly-ubiquitinylated proteins. In infectious disease, cells activated by interferons (IFNs) express three unique catalytic subunits β1i/LMP2, β2i/MECL-1 and β5i/LMP7 forming an alternative proteasome isoform, the ...
Elisa Opitz, Annett Koch, Karin Klingel, Frank Schmidt, Stefan Prokop, Anna Rahnefeld, Martina Sauter, Frank L Heppner, Uwe Völker, Reinhard Kandolf, Ulrike Kuckelkorn, Karl Stangl, Elke Krüger, Peter M Kloetzel, Antje Voigt   +14 more
doaj   +4 more sources

Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema Via Activating NRF1/2‐P62 Axis and Suppressing IRF4 Transcription

Advanced Science
Chronic obstructive pulmonary disease (COPD) stands as the prevailing chronic airway ailment, characterized by chronic bronchitis and emphysema. Current medications fall short in treatment of these diseases, underscoring the urgent need for effective ...
Bingxin Guo, Xing Shi, Qiong Jiang, Yuanwei Pan, Yuqiong Yang, Yuanyuan Liu, Shuyu Chen, Wenjiao Zhu, Laibin Ren, Ruifang Liang, Xue Chen, Haizhao Xu, Laiyou Wei, Yongjian Lin, Jinyong Wang, Chen Qiu, Haibo Zhou, Lang Rao, Lingwei Wang, Rongchang Chen, Shanze Chen   +20 more
doaj   +2 more sources

LMP2 and LMP7 gene polymorphism in Mexican populations: Mestizos and Amerindians [PDF]

Genes & Immunity, 2002
Low molecular weight polypeptide (LMP) genes are located within the major histocompatibility complex and have been associated with autoimmune diseases such as ankylosing spondylitis. In order to define the distribution of LMP genes in Mexican populations, the LMP2 and LMP7 polymorphism was analyzed in 312 Mexican individuals (95 Mexican Mestizos, 48 ...
G, Vargas-Alarcón, R, Gamboa, Y, Vergara, J M, Rodriguez-Zepeda, A, de la Peña, R, Izaguirre, J, Zuñiga, J A, Ruiz-Morales, J, Granados   +8 more
openaire   +2 more sources

Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. [PDF]

PLoS ONE, 2016
Immunoproteasomes, harboring the active site subunits β5i/LMP7, β1i/LMP2, and β2i/MECL1 exert protective, regulatory or modulating functions during infection-induced immune responses.
Felicia Kirschner, Katrin Reppe, Nadine Andresen, Martin Witzenrath, Frédéric Ebstein, Peter-Michael Kloetzel   +5 more
doaj   +1 more source

Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders [PDF]

Scientific Reports, 2015
AbstractInflammation plays an important role in the development of obesity and metabolic disorders; however, it has not been fully understood how inflammation occurs and is regulated in their pathogenesis. Low-molecular mass protein-7 (LMP7) is a proteolytic subunit of the immunoproteasome that shapes the repertoire of antigenic peptides on major ...
Hiroaki Kimura, Fumitake Usui, Tadayoshi Karasawa, Akira Kawashima, Koumei Shirasuna, Yoshiyuki Inoue, Takanori Komada, Motoi Kobayashi, Yoshiko Mizushina, Tadashi Kasahara, Koichi Suzuki, Yusaku Iwasaki, Toshihiko Yada, Patrizio Caturegli, Masafumi Takahashi   +14 more
openaire   +2 more sources

Charakterisierung der Auswirkungen einer Defizienz der proteasomalen Untereinheit β5/LMP7 auf die Funktion von Monozyten und Makrophagen [PDF]

, 2020
Klinische Manifestationen der Atherosklerose (z.B. Myokardinfarkt, Schlaganfall) stellen weltweit die häufigste Todesursache dar. Die Atherosklerose ist eine chronisch entzündliche Erkrankung der arteriellen Gefäße an deren Pathogenese u.a.
Pötzsch, Max
core   +1 more source

Correction to "Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema via Activating NRF1/2-P62 Axis and Suppressing IRF4 Transcription". [PDF]

Adv Sci (Weinh)
Advanced Science, Volume 13, Issue 11, 23 February 2026.
europepmc   +2 more sources