Characterization of the immunproteasome subunits LMP2 and LMP7 in the mouse brain
, 2018 Die hier verfasste Dissertation beinhaltet eine Lokalisationsstudie sowie eine funktionelle Charakterisierung der katalytischen Untereinheiten LMP2 und LMP7 des Immunoproteasomes (IPs) im Gehirn der Maus. Das IP ist eine spezifische Form des Proteasoms, welches konstitutiv in Zellen des Immunsystems exprimiert wird und auf Grund seiner speziellen ...
Säring, Paula
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PLoS ONE, 2020 Aging is a major risk factor for morbidity and mortality from cardiovascular causes in men. To better understand the cellular processes related to age-related cardiac complications, we undertook research aimed at comparative evaluation of genes ...
Irena Kasacka +4 more
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The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis [PDF]
Frontiers in Immunology, 2021 Cell survival and function critically relies on the fine-tuned balance of protein synthesis and degradation. In the steady state, the standard proteasome is sufficient to maintain this proteostasis.
Timothy French +15 more
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The role of immunoproteasomes in modulating neuro‐inflammation in Alzheimer’s Disease [PDF]
Alzheimers DementAbstract Background The immunoproteasome (IP) is the inducible form of the constitutive 20S proteasome upregulated in immune cells. The IP consists of 3 inducible β subunits (β1i – LMP2, β2i – MECL1, and β5i – LMP7), which generate MHC‐I compatible peptides.
Kumar M +7 more
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IRF‐1 mediates upregulation of LMP7 by IFN‐γ and concerted expression of immunosubunits of the proteasome [PDF]
FEBS Letters, 2005 An immunoproteasome subunit low molecular weight protein 7 (LMP7) plays critical roles in major histocompatibility complex class I antigen processing; however, the mechanism for its expression has remained unclear. We demonstrate that interferon (IFN) regulatory factor‐1 (IRF‐1) has a pivotal role in IFN‐γ‐dependent LMP7 expression, as was shown for ...
Namiki, Shin +8 more
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EBioMedicine, 2018 Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders.
Scott Ugras +14 more
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Three-Dimensional Tumor Spheroids Reveal B7-H3 CAR T Cell Infiltration Dynamics and Microenvironment-Induced Functional Reprogramming in Solid Tumors [PDF]
CellsChimeric antigen receptor (CAR) T cell therapy has demonstrated clinical success in hematologic malignancies but has limited efficacy in solid tumors due to tumor microenvironment (TME) barriers that impede CAR T cell recognition, infiltration, and ...
Feng Chen +5 more
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Evidence of Immunoproteasome Expression Onset in the Formative State of Pluripotency in Mouse Cells [PDF]
CellsEmbryonic stem cells (ESCs) are remarkable for the high activity level of ubiquitin–proteasome system—the molecular machinery of protein degradation in the cell.
Daria Kriger +6 more
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PLoS Pathogens, 2011 Proteasomes recognize and degrade poly-ubiquitinylated proteins. In infectious disease, cells activated by interferons (IFNs) express three unique catalytic subunits β1i/LMP2, β2i/MECL-1 and β5i/LMP7 forming an alternative proteasome isoform, the ...
Elisa Opitz +14 more
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LMP7-Specific Inhibitor M3258 Modulates the Tumor Microenvironment of Triple-Negative Breast Cancer and Inflammatory Breast Cancer [PDF]
CancersMichael Sanderson, Xuemei Xie
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