LMP2 and LMP7 gene polymorphism in Mexican populations: Mestizos and Amerindians [PDF]
Genes & Immunity, 2002 Low molecular weight polypeptide (LMP) genes are located within the major histocompatibility complex and have been associated with autoimmune diseases such as ankylosing spondylitis. In order to define the distribution of LMP genes in Mexican populations, the LMP2 and LMP7 polymorphism was analyzed in 312 Mexican individuals (95 Mexican Mestizos, 48 ...
G, Vargas-Alarcón +8 more
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Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. [PDF]
PLoS ONE, 2016 Immunoproteasomes, harboring the active site subunits β5i/LMP7, β1i/LMP2, and β2i/MECL1 exert protective, regulatory or modulating functions during infection-induced immune responses.
Felicia Kirschner +5 more
doaj +1 more source
Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders [PDF]
Scientific Reports, 2015 AbstractInflammation plays an important role in the development of obesity and metabolic disorders; however, it has not been fully understood how inflammation occurs and is regulated in their pathogenesis. Low-molecular mass protein-7 (LMP7) is a proteolytic subunit of the immunoproteasome that shapes the repertoire of antigenic peptides on major ...
Hiroaki Kimura +14 more
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Charakterisierung der Auswirkungen einer Defizienz der proteasomalen Untereinheit β5/LMP7 auf die Funktion von Monozyten und Makrophagen [PDF]
, 2020 Klinische Manifestationen der Atherosklerose (z.B. Myokardinfarkt, Schlaganfall) stellen weltweit die häufigste Todesursache dar. Die Atherosklerose ist eine chronisch entzündliche Erkrankung der arteriellen Gefäße an deren Pathogenese u.a.
Pötzsch, Max
core +1 more source
Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis
Life, 2021 Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk ...
Wanda Niepiekło-Miniewska +6 more
doaj +1 more source
Immunoproteasome subunit LMP7-deficiency in initiation and progression of atherosclerosis
, 2021 Die Atherosklerose ist eine chronisch entzündliche Gefäßerkrankung, die erheblich zur globalen Morbidität und Mortalität beiträgt. Die Atherogenese geht mit einer Dysregulation des Ubiquitin-Proteasom-Systems (UPS) einher.
Dan, Cristian Ioan
core +1 more source
Post-transcriptional and epigenetic regulation of antigen processing machinery (APM) components and HLA-I in cervical cancers from Uighur women. [PDF]
PLoS ONE, 2012 Normal function of human leukocyte antigen class I (HLA-I) and antigen processing machinery (APM) proteins is required for T cell-mediated anti-tumor or antiviral immunity, whereas the tumor survival indicates a failure of the host in immune surveillance
Ayshamgul Hasim +7 more
doaj +1 more source
mBio, 2020 The proteasome is a major protein degradation machinery with essential and diverse biological functions. Upon induction by cytokines, proteasome subunits β1, β2, and β5 are replaced by β1i/LMP2, β2i/MECL-1, and β5i/LMP7, resulting in the formation of an ...
Yang Yang +13 more
doaj +1 more source
Selective targeting of immunoproteasome subunit LMP7 prevents colitis-associated carcinogenesis
, 2016 Chronic inflammation is a well-known risk factor for the development of colonic tumorigenesis. In this study, we show that the immunoproteasome (iP) subunit LMP7 plays a crucial role in the progression of colitis-associated carcinogenesis (CAC).
Vachharajani, Niyati +1 more
core +2 more sources
Acta Neuropathologica Communications, 2017 The immunoproteasome (iP) represents a specialized type of proteasomes, which plays an important role in the clearance of oxidant-damaged proteins under inflammatory and pathological conditions determining the outcome of various diseases.
Lisa K. Wagner +6 more
doaj +1 more source