Results 31 to 40 of about 2,423 (198)
Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis
Life, 2021 Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk ...
Wanda Niepiekło-Miniewska +6 more
doaj +1 more source
Frontiers in Oncology, 2020 ObjectiveThe Wnt/ß-catenin pathway plays an important role in pathogenesis of variety cancers. Most studies on changes in WNT/β-catenin pathway in renal cell carcinoma (RCC) apply only to clear cell RCC, while there are no comparative assessments of this
Żaneta Piotrowska +4 more
doaj +1 more source
Post-transcriptional and epigenetic regulation of antigen processing machinery (APM) components and HLA-I in cervical cancers from Uighur women. [PDF]
PLoS ONE, 2012 Normal function of human leukocyte antigen class I (HLA-I) and antigen processing machinery (APM) proteins is required for T cell-mediated anti-tumor or antiviral immunity, whereas the tumor survival indicates a failure of the host in immune surveillance
Ayshamgul Hasim +7 more
doaj +1 more source
Immunoproteasome subunit LMP7-deficiency in initiation and progression of atherosclerosis
, 2021 Die Atherosklerose ist eine chronisch entzündliche Gefäßerkrankung, die erheblich zur globalen Morbidität und Mortalität beiträgt. Die Atherogenese geht mit einer Dysregulation des Ubiquitin-Proteasom-Systems (UPS) einher.
Dan, Cristian Ioan
core +1 more source
mBio, 2020 The proteasome is a major protein degradation machinery with essential and diverse biological functions. Upon induction by cytokines, proteasome subunits β1, β2, and β5 are replaced by β1i/LMP2, β2i/MECL-1, and β5i/LMP7, resulting in the formation of an ...
Yang Yang +13 more
doaj +1 more source
Acta Neuropathologica Communications, 2017 The immunoproteasome (iP) represents a specialized type of proteasomes, which plays an important role in the clearance of oxidant-damaged proteins under inflammatory and pathological conditions determining the outcome of various diseases.
Lisa K. Wagner +6 more
doaj +1 more source
Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. [PDF]
PLoS ONE, 2016 The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome.
Haiming M Liu +3 more
doaj +1 more source
Food Science of Animal Resources, 2017 In this study, two Listeria bacteriophages, LMP1 and LMP7, were isolated from chicken feces as a means of biocontrol of L. monocytogenes. Both bacteriophages had a lytic effect on L. monocytogenes ATCC 7644, 15313, 19114, and 19115.
Sunhee Lee +5 more
doaj +1 more source
Association of LMP/TAP gene polymorphisms with tuberculosis susceptibility in Li population in China. [PDF]
PLoS ONE, 2012 BACKGROUND: Tuberculosis (TB) is a contagious disease affected by multiple genetic and environmental factors. Several association studies have suggested that cellular immune response is vital for controlling and preventing of tuberculosis infection.
Danmei Wang +7 more
doaj +1 more source
On the Role of the Immunoproteasome in Protein Homeostasis
Cells, 2021 Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
doaj +1 more source