Results 31 to 40 of about 1,819 (163)

HIV-1 Nef Interacts with LMP7 To Attenuate Immunoproteasome Formation and Major Histocompatibility Complex Class I Antigen Presentation

mBio, 2020
The proteasome is a major protein degradation machinery with essential and diverse biological functions. Upon induction by cytokines, proteasome subunits β1, β2, and β5 are replaced by β1i/LMP2, β2i/MECL-1, and β5i/LMP7, resulting in the formation of an ...
Yang Yang, Weiyong Liu, Dan Hu, Rui Su, Man Ji, Yuqing Huang, Muhammad Adnan Shereen, Xiaodi Xu, Zhen Luo, Qi Zhang, Fang Liu, Kailang Wu, Yingle Liu, Jianguo Wu   +13 more
doaj   +1 more source

Determining the Potential Roles of Branched‐Chain Amino Acids in the Regulation of Muscle Growth in Common Carp (Cyprinus carpio) Based on Transcriptome and MicroRNA Sequencing

Aquaculture Nutrition, Volume 2023, Issue 1, 2023., 2023
Branched‐chain amino acids (BCAAs) can be critically involved in skeletal muscle growth and body energy homeostasis. Skeletal muscle growth is a complex process; some muscle‐specific microRNAs (miRNAs) are involved in the regulation of muscle thickening and muscle mass.
Xianglin Cao, Han Cui, Xinyu Ji, Baohua Li, Ronghua Lu, Yuru Zhang, Jianjun Chen, Shivendra Kumar   +7 more
wiley   +1 more source

Effective therapy of polymyositis in mice via selective inhibition of the immunoproteasome

European Journal of Immunology, Volume 52, Issue 9, Page 1510-1522, September 2022., 2022
Using a murine model of polymyositis, known as C protein‐induced myositis, we showed that immunoproteasome inhibitors reduced the lesions and inflammatory infiltrates in the muscular tissue while normalizing grip strength. LMP7‐deficient mice did not develop the disease.
Marta del Rio Oliva, Christopher J Kirk, Marcus Groettrup, Michael Basler   +3 more
wiley   +1 more source

Immunoproteasome modulates NLRP3 inflammasome‐mediated neuroinflammation under cerebral ischaemia and reperfusion conditions

Journal of Cellular and Molecular Medicine, Volume 26, Issue 2, Page 462-474, January 2022., 2022
Abstract Compelling evidence showed that both nucleotide‐binding oligomerization domain‐like receptor family, pyrin domain‐containing protein 3 (NLRP3) inflammasomes and the immunoproteasome participate in neuroinflammatory responses in cerebral ischaemia injury. Moreover, inhibition of either NLRP3 inflammasomes or the immunoproteasome attenuates both
Xingyong Chen, Yinzhou Wang, Nannan Yao, Zejing Lin   +3 more
wiley   +1 more source

Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7 [PDF]

Oncotarget, 2017
Chronic inflammation is a well-known risk factor in development of intestinal tumorigenesis, although the exact mechanisms underlying development of colitis-associated cancer (CAC) still remain obscure. The activity and function of immunoproteasome has been extensively analyzed in the context of inflammation and infectious diseases.
Vachharajani, Niyati, Joeris, Thorsten, Luu, Maik, Hartmann, Sabrina, Pautz, Sabine, Jenike, Elena, Pantazis, Georgios, Prinz, Immo, Hofer, Markus J, Steinhoff, Ulrich, Visekruna, Alexander   +10 more
openaire   +2 more sources

Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer’s disease-like APPPS1 mice

Acta Neuropathologica Communications, 2017
The immunoproteasome (iP) represents a specialized type of proteasomes, which plays an important role in the clearance of oxidant-damaged proteins under inflammatory and pathological conditions determining the outcome of various diseases.
Lisa K. Wagner, Kate E. Gilling, Eileen Schormann, Peter M. Kloetzel, Frank L. Heppner, Elke Krüger, Stefan Prokop   +6 more
doaj   +1 more source

Ageing-related changes in the levels of β-catenin, CacyBP/SIP, galectin-3 and immunoproteasome subunit LMP7 in the heart of men.

PLoS ONE, 2020
Aging is a major risk factor for morbidity and mortality from cardiovascular causes in men. To better understand the cellular processes related to age-related cardiac complications, we undertook research aimed at comparative evaluation of genes ...
Irena Kasacka, Żaneta Piotrowska, Michał Niezgoda, Alicja Lewandowska, Wojciech Łebkowski   +4 more
doaj   +1 more source

Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. [PDF]

PLoS ONE, 2016
The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome.
Haiming M Liu, Deborah A Ferrington, Cory W Baumann, LaDora V Thompson   +3 more
doaj   +1 more source

Isolation and Characterization of Listeria phages for Control of Growth of Listeria monocytogenes in Milk

Food Science of Animal Resources, 2017
In this study, two Listeria bacteriophages, LMP1 and LMP7, were isolated from chicken feces as a means of biocontrol of L. monocytogenes. Both bacteriophages had a lytic effect on L. monocytogenes ATCC 7644, 15313, 19114, and 19115.
Sunhee Lee, Min Gon Kim, Hee Soo Lee, Sunhak Heo, Mirae Kwon, GeunBae Kim   +5 more
doaj   +1 more source

The role of immunoproteasomes in modulating neuro‐inflammation in Alzheimer’s Disease [PDF]

Alzheimers Dement
Abstract Background The immunoproteasome (IP) is the inducible form of the constitutive 20S proteasome upregulated in immune cells. The IP consists of 3 inducible β subunits (β1i – LMP2, β2i – MECL1, and β5i – LMP7), which generate MHC‐I compatible peptides.
Kumar M, Jiang S, Lorman D, David L, Soni R, Kissner M, Yang M, Myeku N.   +7 more
europepmc   +2 more sources