Results 41 to 50 of about 2,423 (198)

Corneal wound healing is compromised by immunoproteasome deficiency. [PDF]

PLoS ONE, 2013
Recent studies have revealed roles for immunoproteasome in regulating cell processes essential for maintaining homeostasis and in responding to stress and injury.
Deborah A Ferrington, Heidi Roehrich, Angela A Chang, Craig W Huang, Marcela Maldonado, Wendy Bratten, Abrar A Rageh, Neal D Heuss, Dale S Gregerson, Elizabeth F Nelson, Ching Yuan   +10 more
doaj   +1 more source

Tissue‐specific up‐regulation of the proteasome subunit β5i (LMP7) in Sjögren's syndrome [PDF]

Arthritis & Rheumatism, 2006
AbstractObjectiveSjögren's syndrome (SS) is characterized by autoimmune infiltration and focal accumulation of lymphocytes in the exocrine glands, with a predominance of CD4‐positive T cells. Since these histologic findings are nonspecific, determination of clinical and serologic abnormalities contribute to the diagnosis.
Thomas, Egerer, Lorena, Martinez-Gamboa, Anja, Dankof, Bruno, Stuhlmüller, Thomas, Dörner, Veit, Krenn, Karl, Egerer, Paul E, Rudolph, Gerd-R, Burmester, Eugen, Feist   +9 more
openaire   +2 more sources

Deficiency of LMP10 Attenuates Diet-Induced Atherosclerosis by Inhibiting Macrophage Polarization and Inflammation in Apolipoprotein E Deficient Mice

Frontiers in Cell and Developmental Biology, 2020
Macrophage polarization and inflammation are key factors for the onset and progression of atherosclerosis. The immunoproteasome complex consists of three inducible catalytic subunits (LMP2, LMP10, and LMP7) that play a critical role in the regulation of ...
Jiawei Liao, Xiangbo An, Xiaolei Yang, Qiu-Yue Lin, Shuang Liu, Yunpeng Xie, Jie Bai, Yun-Long Xia, Hui-Hua Li, Hui-Hua Li   +9 more
doaj   +1 more source

Immunoproteasome deficiency modifies the alternative pathway of NFκB signaling. [PDF]

PLoS ONE, 2013
Immunoproteasome is a protease abundant in immune cells and also present, albeit at lower concentrations, in cells outside the immune system. Recent evidence supports a novel role for the immunoproteasome in the cellular stress response potentially ...
Marcela Maldonado, Rebecca J Kapphahn, Marcia R Terluk, Neal D Heuss, Ching Yuan, Dale S Gregerson, Deborah A Ferrington   +6 more
doaj   +1 more source

Suppression of prostate cancer and amelioration of the immunosuppressive tumor microenvironment through selective immunoproteasome inhibition

OncoImmunology, 2023
New treatment options to battle hormone-refractory prostate carcinoma (PC) are a pressing medical need. Chronic inflammation has been implicated in PC etiology.
Julia Koerner, Dennis Horvath, Franziska Oliveri, Jun Li, Michael Basler   +4 more
doaj   +1 more source

Co-immunoprecipitation analysis using proβ5- and LMP7-containing proteasome subunits over-expressed in lmp7^−/−Mefs.

, 2012
Flag-tagged full-length LMP7 (LMP7-Flag), proLMP7 fused to mature β5 (proLMP7mβ5-Flag), full-length β5 (β5-Flag) and proβ5 fused to mature LMP7 (proβ5mLMP7-Flag) were over-expressed in lmp7−/−Mefs by retroviral transduction (A).
Nicole Schmidt (154421), Ulrich Steinhoff (154431), Stefan H. E. Kaufmann (149315), Petra Krienke (154424), Alexander Visekruna (154426), Ulrike Kuckelkorn (154428), David Ermert (154423), Thorsten Joeris (154419)   +7 more
core   +1 more source

The LMP7-K Allele of the Immunoproteasome Exhibits Reduced Transcript Stability and Predicts High Risk of Colon Cancer

, 2011
Destruction of cancer cells by cytotoxic T lymphocytes depends on immunogenic tumor peptides generated by proteasomes and presented by human leukocyte antigen (HLA) molecules.
Andreas G. Nerlich, Rudolf Wank, Barbara Fellerhoff, Reinhard Kopp, Judith P. Johnson, Barbara Laumbacher, Songhai Gu, Elisabeth H. Weiss, Jürgen Glas   +8 more
core   +1 more source

Trypanosoma cruzi infection down-modulates the immunoproteasome biosynthesis and the MHC class I cell surface expression in HeLa cells. [PDF]

PLoS ONE, 2014
Generally, Trypanosoma cruzi infection in human is persistent and tends to chronicity, suggesting that the parasite evade the immune surveillance by down regulating the intracellular antigen processing routes. Within the MHC class I pathway, the majority
Ricardo Camargo, Liliam O Faria, Alexander Kloss, Cecília B F Favali, Ulrike Kuckelkorn, Peter-Michael Kloetzel, Cezar Martins de Sá, Beatriz D Lima   +7 more
doaj   +1 more source

Expression of genes coding for β-catenin, CacyBP/SIP, galectin-3 and LMP7 in men hearts (mean ± SE).

, 2020
The correlation between expression of gene coding for β-catenin, CacyBP/SIP, galectin-3, LMP7 and individual’s age.
Irena Kasacka (8520003), Wojciech Łebkowski (8520015), Żaneta Piotrowska (8520006), Alicja Lewandowska (8520012), Michał Niezgoda (8520009)   +4 more
core   +1 more source

The role of immunoproteasomes in modulating neuro‐inflammation in Alzheimer’s Disease [PDF]

Alzheimers Dement
Abstract Background The immunoproteasome (IP) is the inducible form of the constitutive 20S proteasome upregulated in immune cells. The IP consists of 3 inducible β subunits (β1i – LMP2, β2i – MECL1, and β5i – LMP7), which generate MHC‐I compatible peptides.
Kumar M, Jiang S, Lorman D, David L, Soni R, Kissner M, Yang M, Myeku N.   +7 more
europepmc   +2 more sources