Results 41 to 50 of about 1,819 (163)

Association of LMP/TAP gene polymorphisms with tuberculosis susceptibility in Li population in China. [PDF]

PLoS ONE, 2012
BACKGROUND: Tuberculosis (TB) is a contagious disease affected by multiple genetic and environmental factors. Several association studies have suggested that cellular immune response is vital for controlling and preventing of tuberculosis infection.
Danmei Wang, Yue Zhou, Limin Ji, Tong He, Feng Lin, Rong Lin, Tangchang Lin, Yanna Mo   +7 more
doaj   +1 more source

On the Role of the Immunoproteasome in Protein Homeostasis

Cells, 2021
Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
doaj   +1 more source

Deficiency of LMP10 Attenuates Diet-Induced Atherosclerosis by Inhibiting Macrophage Polarization and Inflammation in Apolipoprotein E Deficient Mice

Frontiers in Cell and Developmental Biology, 2020
Macrophage polarization and inflammation are key factors for the onset and progression of atherosclerosis. The immunoproteasome complex consists of three inducible catalytic subunits (LMP2, LMP10, and LMP7) that play a critical role in the regulation of ...
Jiawei Liao, Xiangbo An, Xiaolei Yang, Qiu-Yue Lin, Shuang Liu, Yunpeng Xie, Jie Bai, Yun-Long Xia, Hui-Hua Li, Hui-Hua Li   +9 more
doaj   +1 more source

Corneal wound healing is compromised by immunoproteasome deficiency. [PDF]

PLoS ONE, 2013
Recent studies have revealed roles for immunoproteasome in regulating cell processes essential for maintaining homeostasis and in responding to stress and injury.
Deborah A Ferrington, Heidi Roehrich, Angela A Chang, Craig W Huang, Marcela Maldonado, Wendy Bratten, Abrar A Rageh, Neal D Heuss, Dale S Gregerson, Elizabeth F Nelson, Ching Yuan   +10 more
doaj   +1 more source

Tissue‐specific up‐regulation of the proteasome subunit β5i (LMP7) in Sjögren's syndrome [PDF]

Arthritis & Rheumatism, 2006
AbstractObjectiveSjögren's syndrome (SS) is characterized by autoimmune infiltration and focal accumulation of lymphocytes in the exocrine glands, with a predominance of CD4‐positive T cells. Since these histologic findings are nonspecific, determination of clinical and serologic abnormalities contribute to the diagnosis.
Thomas, Egerer, Lorena, Martinez-Gamboa, Anja, Dankof, Bruno, Stuhlmüller, Thomas, Dörner, Veit, Krenn, Karl, Egerer, Paul E, Rudolph, Gerd-R, Burmester, Eugen, Feist   +9 more
openaire   +2 more sources

Immunoproteasome deficiency modifies the alternative pathway of NFκB signaling. [PDF]

PLoS ONE, 2013
Immunoproteasome is a protease abundant in immune cells and also present, albeit at lower concentrations, in cells outside the immune system. Recent evidence supports a novel role for the immunoproteasome in the cellular stress response potentially ...
Marcela Maldonado, Rebecca J Kapphahn, Marcia R Terluk, Neal D Heuss, Ching Yuan, Dale S Gregerson, Deborah A Ferrington   +6 more
doaj   +1 more source

Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

EBioMedicine, 2018
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders.
Scott Ugras, Malcolm J. Daniels, Hossein Fazelinia, Neal S. Gould, Anastasia K. Yocum, Kelvin C. Luk, Esteban Luna, Hua Ding, Chris McKennan, Steven Seeholzer, Dan Martinez, Perry Evans, Daniel Brown, John E. Duda, Harry Ischiropoulos   +14 more
doaj   +1 more source

Suppression of prostate cancer and amelioration of the immunosuppressive tumor microenvironment through selective immunoproteasome inhibition

OncoImmunology, 2023
New treatment options to battle hormone-refractory prostate carcinoma (PC) are a pressing medical need. Chronic inflammation has been implicated in PC etiology.
Julia Koerner, Dennis Horvath, Franziska Oliveri, Jun Li, Michael Basler   +4 more
doaj   +1 more source

Activity of immunoproteasome inhibitor ONX-0914 in acute lymphoblastic leukemia expressing MLL–AF4 fusion protein

Scientific Reports, 2021
Proteasome inhibitors bortezomib and carfilzomib are approved for the treatment of multiple myeloma and mantle cell lymphoma and have demonstrated clinical efficacy for the treatment of acute lymphoblastic leukemia (ALL). The t(4;11)(q21;q23) chromosomal
Tyler W. Jenkins, Sondra L. Downey-Kopyscinski, Jennifer L. Fields, Gilbert J. Rahme, William C. Colley, Mark A. Israel, Andrey V. Maksimenko, Steven N. Fiering, Alexei F. Kisselev   +8 more
doaj   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source