Results 41 to 50 of about 2,385 (193)

Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. [PDF]

PLoS ONE, 2016
The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome.
Haiming M Liu, Deborah A Ferrington, Cory W Baumann, LaDora V Thompson   +3 more
doaj   +1 more source

Isolation and Characterization of Listeria phages for Control of Growth of Listeria monocytogenes in Milk

Food Science of Animal Resources, 2017
In this study, two Listeria bacteriophages, LMP1 and LMP7, were isolated from chicken feces as a means of biocontrol of L. monocytogenes. Both bacteriophages had a lytic effect on L. monocytogenes ATCC 7644, 15313, 19114, and 19115.
Sunhee Lee, Min Gon Kim, Hee Soo Lee, Sunhak Heo, Mirae Kwon, GeunBae Kim   +5 more
doaj   +1 more source

Association of LMP/TAP gene polymorphisms with tuberculosis susceptibility in Li population in China. [PDF]

PLoS ONE, 2012
BACKGROUND: Tuberculosis (TB) is a contagious disease affected by multiple genetic and environmental factors. Several association studies have suggested that cellular immune response is vital for controlling and preventing of tuberculosis infection.
Danmei Wang, Yue Zhou, Limin Ji, Tong He, Feng Lin, Rong Lin, Tangchang Lin, Yanna Mo   +7 more
doaj   +1 more source

On the Role of the Immunoproteasome in Protein Homeostasis

Cells, 2021
Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
doaj   +1 more source

Corneal wound healing is compromised by immunoproteasome deficiency. [PDF]

PLoS ONE, 2013
Recent studies have revealed roles for immunoproteasome in regulating cell processes essential for maintaining homeostasis and in responding to stress and injury.
Deborah A Ferrington, Heidi Roehrich, Angela A Chang, Craig W Huang, Marcela Maldonado, Wendy Bratten, Abrar A Rageh, Neal D Heuss, Dale S Gregerson, Elizabeth F Nelson, Ching Yuan   +10 more
doaj   +1 more source

Tissue‐specific up‐regulation of the proteasome subunit β5i (LMP7) in Sjögren's syndrome [PDF]

Arthritis & Rheumatism, 2006
AbstractObjectiveSjögren's syndrome (SS) is characterized by autoimmune infiltration and focal accumulation of lymphocytes in the exocrine glands, with a predominance of CD4‐positive T cells. Since these histologic findings are nonspecific, determination of clinical and serologic abnormalities contribute to the diagnosis.
Thomas, Egerer, Lorena, Martinez-Gamboa, Anja, Dankof, Bruno, Stuhlmüller, Thomas, Dörner, Veit, Krenn, Karl, Egerer, Paul E, Rudolph, Gerd-R, Burmester, Eugen, Feist   +9 more
openaire   +2 more sources

Deficiency of LMP10 Attenuates Diet-Induced Atherosclerosis by Inhibiting Macrophage Polarization and Inflammation in Apolipoprotein E Deficient Mice

Frontiers in Cell and Developmental Biology, 2020
Macrophage polarization and inflammation are key factors for the onset and progression of atherosclerosis. The immunoproteasome complex consists of three inducible catalytic subunits (LMP2, LMP10, and LMP7) that play a critical role in the regulation of ...
Jiawei Liao, Xiangbo An, Xiaolei Yang, Qiu-Yue Lin, Shuang Liu, Yunpeng Xie, Jie Bai, Yun-Long Xia, Hui-Hua Li, Hui-Hua Li   +9 more
doaj   +1 more source

Immunoproteasome deficiency modifies the alternative pathway of NFκB signaling. [PDF]

PLoS ONE, 2013
Immunoproteasome is a protease abundant in immune cells and also present, albeit at lower concentrations, in cells outside the immune system. Recent evidence supports a novel role for the immunoproteasome in the cellular stress response potentially ...
Marcela Maldonado, Rebecca J Kapphahn, Marcia R Terluk, Neal D Heuss, Ching Yuan, Dale S Gregerson, Deborah A Ferrington   +6 more
doaj   +1 more source

Suppression of prostate cancer and amelioration of the immunosuppressive tumor microenvironment through selective immunoproteasome inhibition

OncoImmunology, 2023
New treatment options to battle hormone-refractory prostate carcinoma (PC) are a pressing medical need. Chronic inflammation has been implicated in PC etiology.
Julia Koerner, Dennis Horvath, Franziska Oliveri, Jun Li, Michael Basler   +4 more
doaj   +1 more source

Trypanosoma cruzi infection down-modulates the immunoproteasome biosynthesis and the MHC class I cell surface expression in HeLa cells. [PDF]

PLoS ONE, 2014
Generally, Trypanosoma cruzi infection in human is persistent and tends to chronicity, suggesting that the parasite evade the immune surveillance by down regulating the intracellular antigen processing routes. Within the MHC class I pathway, the majority
Ricardo Camargo, Liliam O Faria, Alexander Kloss, Cecília B F Favali, Ulrike Kuckelkorn, Peter-Michael Kloetzel, Cezar Martins de Sá, Beatriz D Lima   +7 more
doaj   +1 more source