Results 61 to 70 of about 2,385 (193)

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, Volume 2, Issue 2, Page 343-370, June 2026.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis [PDF]

Respiratory Medicine, 2010
Hypersensitivity Pneumonitis (HP) is a lung inflammatory disorder caused by inhalation of organic particles by a susceptible host. However, only a small proportion of individuals exposed to HP-associated antigens develop the disease, suggesting that additional host/environmental factors may play a role.
Camarena, Ángel, Aquino-Galvez, Arnoldo, Falfán-Valencia, Ramcés, Sánchez, Gloria, Montaño, Martha, Ramos, Carlos, Juárez, Armida, García-de-Alba, Carolina, Granados, Julio, Selman, Moisés   +9 more
openaire   +2 more sources

Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells. [PDF]

PLoS ONE, 2017
Human cancers are known to downregulate Major Histocompatibility Complex (MHC) class I expression thereby escaping recognition and rejection by anti-tumor T cells.
Shalini Sethumadhavan, Murillo Silva, Phaethon Philbrook, Thao Nguyen, Stephen M Hatfield, Akio Ohta, Michail V Sitkovsky   +6 more
doaj   +1 more source

Subversion of immunoproteasome subunit expression in dengue virus serotype 2-infected HepG2 cells

Revista da Sociedade Brasileira de Medicina Tropical
: INTRODUCTION: Infection with all serotypes of dengue virus (DV) results in augmented antigen presentation by MHC class I molecules. However, the upregulation of immunoproteasome subunits only results from infection with two serotypes. This study aims
Chye Sheng Gan, Pei Jean Lim, Muhammad Fazril Mohamad Razif, Rohana Yusof, Shatrah Othman   +4 more
doaj   +1 more source

Immunoproteasome deficiency protects in the retina after optic nerve crush. [PDF]

PLoS ONE, 2015
The immunoproteasome is upregulated by disease, oxidative stress, and inflammatory cytokines, suggesting an expanded role for the immunoproteasome in stress signaling that goes beyond its canonical role in generating peptides for antigen presentation ...
Nathan J Schuld, Stacy A Hussong, Rebecca J Kapphahn, Ute Lehmann, Heidi Roehrich, Abrar A Rageh, Neal D Heuss, Wendy Bratten, Dale S Gregerson, Deborah A Ferrington   +9 more
doaj   +1 more source

Human Leukocyte Antigen (HLA) and Tumor Immunity: A Critical Link in Cancer Immunotherapy

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Malignant tumors pose a serious threat to human health and survival, with profound economic consequences worldwide. Human leukocyte antigens (HLAs), encoded by the human major histocompatibility complex, represent one of the most polymorphic genetic systems and play a vital role in immune regulation.
Donath Damian
wiley   +1 more source

Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation. [PDF]

PLoS ONE, 2013
Alcohol binge-drinking (acute ethanol consumption) is immunosuppressive and alters both the innate and adaptive arms of the immune system. Antigen presentation by macrophages (and other antigen presenting cells) represents an important function of the ...
Alain J D'Souza, Shyamal D Desai, Xiaowen L Rudner, Michelle N Kelly, SanBao Ruan, Judd E Shellito   +5 more
doaj   +1 more source

Hiding in Plain Sight: A Case of Intestinal Tuberculosis Masquerading as Benign Lower GI Bleeding

Case Reports in Gastrointestinal Medicine, Volume 2026, Issue 1, 2026.
Background Intestinal tuberculosis (TB) represents the most common form of abdominal TB, often affecting the ileocaecal region. Lower gastrointestinal bleeding is an uncommon presentation and may create significant diagnostic uncertainty, particularly in immunocompromised patients and in settings where inflammatory bowel disease is also encountered ...
Lavender Otom, Priyanka Panwar, Gerald Odong, Fatma Kassim, Patricia Okiro, Christopher Opio, Saleem Abdulkarim, Neetu Rawal   +7 more
wiley   +1 more source

Immunotherapy Resistance in dMMR/MSI‐H Colorectal Cancer: Unraveling Mechanisms and Exploring Overcoming Strategies

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality worldwide. Approximately 15% of localized and 5% of metastatic cases exhibit mismatch repair deficiency (dMMR) or high microsatellite instability (MSI‐H). While immune checkpoint inhibitors (ICIs) have revolutionized the first‐line treatment for this subgroup, 15%–46% of ...
Ke Zhou, Ping Lu, Hongli Xu, Xinjun Liang, Poorani Gurumallesh Prabu   +4 more
wiley   +1 more source