Results 61 to 70 of about 1,819 (163)

Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers [PDF]

Cancer Research and Treatment, 2019
In the presence of interferon, proteasome subunits are replaced by their inducible counterparts to form an immunoproteasome (IP) plays a key role in generation of antigenic peptides presented by MHC class I molecules, leading to elicitation of a T cell‒mediated immune response.
Lee, Miseon, Song, In Hye, Heo, Sun-Hee, Kim, Young-Ae, Park, In Ah, Bang, Won Seon, Park, Hye Seon, Gong, Gyungyub, Lee, Hee Jin   +8 more
openaire   +2 more sources

CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation

Clinical and Translational Medicine, Volume 14, Issue 12, December 2024.
CircHipk3‐mediated macrophage pyroptosis acts as a critical upstream regulator of inflammatory cytokines and matrix metalloproteinases (MMPs), significantly contributing to abdominal aortic aneurysm (AAA) formation and rupture. CircHipk3 enhances NLRP3 inflammasome activation by interacting with Stat3 and degrading Ptbp1 mRNA, thereby inhibiting ...
Donghua Cai, Chuling Li, Yingyuan Zhang, Sisi He, Yihai Guo, Wangjun Liao, Yulin Liao, Jianping Bin, Xiang He   +8 more
wiley   +1 more source

Immunoproteasome deficiency protects in the retina after optic nerve crush. [PDF]

PLoS ONE, 2015
The immunoproteasome is upregulated by disease, oxidative stress, and inflammatory cytokines, suggesting an expanded role for the immunoproteasome in stress signaling that goes beyond its canonical role in generating peptides for antigen presentation ...
Nathan J Schuld, Stacy A Hussong, Rebecca J Kapphahn, Ute Lehmann, Heidi Roehrich, Abrar A Rageh, Neal D Heuss, Wendy Bratten, Dale S Gregerson, Deborah A Ferrington   +9 more
doaj   +1 more source

Heat Shock Up-Regulates lmp2 and lmp7 and Enhances Presentation of Immunoproteasome-Dependent Epitopes [PDF]

The Journal of Immunology, 2006
Abstract The heat shock response is a canonical regulatory pathway by which cellular stressors such as heat and oxidative stress alter the expression of stress-responsive genes. Some of these stress-responsive genes (heat shock proteins and MHC class I (MHC I)-related chains) play a significant role in the immune system. In this study,
Margaret K, Callahan, Elizabeth A, Wohlfert, Antoine, Ménoret, Pramod K, Srivastava   +3 more
openaire   +2 more sources

Recent Developments and Evolving Therapeutic Strategies in KMT2A‐Rearranged Acute Leukemia

Cancer Medicine, Volume 13, Issue 20, October 2024.
ABSTRACT Background Rearrangements of the histone‐lysine‐N‐methyltransferase (KMT2A), previously referred to as mixed‐lineage leukemia (MLL), are among the most common chromosomal abnormalities in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), involving numerous different fusion partners.
Lei Yin, Lin Wan, Youjian Zhang, Shenghao Hua, Xuejun Shao   +4 more
wiley   +1 more source

Nomenclature for Factors of the HLA System, 2026

HLA, Volume 107, Issue 3, March 2026.
Steven G. E. Marsh, Kazutoyo Osoegawa, Walter F. Bodmer, Ronald E. Bontrop, Mary N. Carrington, Henry A. Erlich, Sebastiaan Heidt, Rhonda Holdsworth, Wolfgang R. Mayr, Martin Maiers, Peter Parham, Effie W. Petersdorf, James Robinson, John Trowsdale, Marcelo Fernández‐Viña   +14 more
wiley   +1 more source

Pluripotent stem cell‐based screening identifies CUDC‐907 as an effective compound for restoring the in vitro phenotype of Nakajo‐Nishimura syndrome

Stem Cells Translational Medicine, 2021
Nakajo‐Nishimura syndrome (NNS) is an autoinflammatory disorder caused by a homozygous mutations in the PSMB8 gene. The administration of systemic corticosteroids is partially effective, but continuous treatment causes severe side effects.
Naoya Kase, Madoka Terashima, Akira Ohta, Akira Niwa, Fumiko Honda‐Ozaki, Yuri Kawasaki, Tatsutoshi Nakahata, Nobuo Kanazawa, Megumu K. Saito   +8 more
doaj   +1 more source

Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co‐regulate proteasomes and mitochondria

The FEBS Journal, Volume 291, Issue 12, Page 2565-2589, June 2024.
A mutation identified in an infant maps to the dimerisation domain of the Parkinson's disease‐associated gene, FBXO7/PARK15, and prevents its interaction with a proteasome regulator, PI31. We characterised the patient's fibroblasts and found multiple deficiencies in proteasome activity and mitochondrial function.
Sara Al Rawi, Lorna Simpson, Guðrún Agnarsdóttir, Neil Q. McDonald, Veronika Chernuha, Orly Elpeleg, Massimo Zeviani, Roger A. Barker, Ronen Spiegel, Heike Laman   +9 more
wiley   +1 more source

Proteasome functioning in breast cancer: connection with clinical-pathological factors. [PDF]

PLoS ONE, 2014
Breast cancer is one of four oncology diseases that are most widespread in the world. Moreover, breast cancer is one of leading causes of cancer-related deaths in female population within economically developed regions of the world.
Elena E Shashova, Yulia V Lyupina, Svetlana A Glushchenko, Elena M Slonimskaya, Olga V Savenkova, Alexey M Kulikov, Nikolay G Gornostaev, Irina V Kondakova, Natalia P Sharova   +8 more
doaj   +1 more source

PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis [PDF]

Respiratory Medicine, 2010
Hypersensitivity Pneumonitis (HP) is a lung inflammatory disorder caused by inhalation of organic particles by a susceptible host. However, only a small proportion of individuals exposed to HP-associated antigens develop the disease, suggesting that additional host/environmental factors may play a role.
Camarena, Ángel, Aquino-Galvez, Arnoldo, Falfán-Valencia, Ramcés, Sánchez, Gloria, Montaño, Martha, Ramos, Carlos, Juárez, Armida, García-de-Alba, Carolina, Granados, Julio, Selman, Moisés   +9 more
openaire   +2 more sources