Results 81 to 90 of about 2,385 (193)

CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation

Clinical and Translational Medicine, Volume 14, Issue 12, December 2024.
CircHipk3‐mediated macrophage pyroptosis acts as a critical upstream regulator of inflammatory cytokines and matrix metalloproteinases (MMPs), significantly contributing to abdominal aortic aneurysm (AAA) formation and rupture. CircHipk3 enhances NLRP3 inflammasome activation by interacting with Stat3 and degrading Ptbp1 mRNA, thereby inhibiting ...
Donghua Cai, Chuling Li, Yingyuan Zhang, Sisi He, Yihai Guo, Wangjun Liao, Yulin Liao, Jianping Bin, Xiang He   +8 more
wiley   +1 more source

Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes

, 2000
Biogenesis of mammalian 20 S proteasomes occurs via precursor complexes containing {alpha} and unprocessed {beta}units. A human homologue of the yeast proteasome maturation factor Ump1 was identified in 2D gels of 16 S precursor preparations and ...
Witt, E., Krueger, E., Zantopf, D., Schmidt, M., Kraft, R., Kloetzel, P.M.   +5 more
core   +1 more source

Nomenclature for Factors of the HLA System, 2026

HLA, Volume 107, Issue 3, March 2026.
Steven G. E. Marsh, Kazutoyo Osoegawa, Walter F. Bodmer, Ronald E. Bontrop, Mary N. Carrington, Henry A. Erlich, Sebastiaan Heidt, Rhonda Holdsworth, Wolfgang R. Mayr, Martin Maiers, Peter Parham, Effie W. Petersdorf, James Robinson, John Trowsdale, Marcelo Fernández‐Viña   +14 more
wiley   +1 more source

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

, 2009
The immunoproteasome, a distinct class of proteasome found predominantly in monocytes and lymphocytes, is known to shape the antigenic repertoire presented on class I major histocompatibility complexes (MHC-I).
Lauer, Christoph, Sylvain, Catherine, Kirk, Christopher J., Muchamuel, Tony, Kalim, Khalid W., Gröttrup, Marcus, Aujay, Monette A., Suzuki, Erika, Ring, Eileen R., Basler, Michael   +9 more
core   +1 more source

Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma

Scientific Reports, 2017
Merkel cell carcinoma (MCC) is a rare and aggressive, yet highly immunogenic skin cancer. The latter is due to its viral or UV-associated carcinogenesis. For tumor progression MCC has to escape the host’s immuno-surveillance, e.g.
Cathrin Ritter, Kaiji Fan, Annette Paschen, Sine Reker Hardrup, Soldano Ferrone, Paul Nghiem, Selma Ugurel, David Schrama, Jürgen C. Becker   +8 more
doaj   +1 more source

Recent Developments and Evolving Therapeutic Strategies in KMT2A‐Rearranged Acute Leukemia

Cancer Medicine, Volume 13, Issue 20, October 2024.
ABSTRACT Background Rearrangements of the histone‐lysine‐N‐methyltransferase (KMT2A), previously referred to as mixed‐lineage leukemia (MLL), are among the most common chromosomal abnormalities in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), involving numerous different fusion partners.
Lei Yin, Lin Wan, Youjian Zhang, Shenghao Hua, Xuejun Shao   +4 more
wiley   +1 more source

Intensity of immunoreaction against β-catenin, CacyBP/SIP, galectin-3 and LMP7 immunoproteasome subunit in men heart (mean ± SE).

, 2020
The correlation between age and intensity of immunohistochemical staining for β-catenin, CacyBP/SIP, galectin-3, LMP7.
Irena Kasacka (8520003), Wojciech Łebkowski (8520015), Żaneta Piotrowska (8520006), Alicja Lewandowska (8520012), Michał Niezgoda (8520009)   +4 more
core   +1 more source

Resistance of LMP7-deficient mice to infection with P. yoelii.

, 2013
(A) Parasitemia (two left panels) and survival ratio (right panel) was monitored in the indicated mice infected with PyL. Each symbol represents parasitemia from an individual mouse, and the numbers or “s” represent day of mouse death or mice survival ...
Makoto Hirai (227542), Hiroko Okada (391891), Hajime Hisaeda (391893), Liping Tu (391888), Kazutomo Suzue (115420), Bin Chou (391887), Chikako Shimokawa (391892), Tomoyo Taniguchi (391890), Takashi Imai (24800), Kunisuke Himeno (391889), Xuefeng Duan (391886)   +10 more
core   +1 more source

Positive test for β-catenin antibody (A) CacyBP/SIP antibody (B), galectin-3 antibody (C) and LMP7 antibody (D).

, 2020
Positive test for β-catenin antibody (A) CacyBP/SIP antibody (B), galectin-3 antibody (C) and LMP7 antibody (D).
Irena Kasacka (8520003), Wojciech Łebkowski (8520015), Żaneta Piotrowska (8520006), Alicja Lewandowska (8520012), Michał Niezgoda (8520009)   +4 more
core   +1 more source

LMP2 and LMP7 Gene Polymorphisms in the Southeastern Anatolia Population of Turkey

INTERNATIONAL JOURNAL OF HUMAN GENETICS, 2013
The low molecular weight polypeptide 2 (LMP2) and low molecular weight polypeptide 7 (LMP7) genes are located in the class II region of the Major Histocompatability Complex (MHC) locus on chromosome 6. These genes encode peptides forming the large components of the proteosome complex which degrades short-lived cytoplasmic proteins.
openaire   +1 more source