Results 91 to 100 of about 2,423 (198)

A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus.

PLoS ONE, 2011
Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates and immunocompromised adults.
Sarah Hutchinson, Stuart Sims, Geraldine O'Hara, Jon Silk, Uzi Gileadi, Vincenzo Cerundolo, Paul Klenerman   +6 more
doaj   +1 more source

Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models

Lipids in Health and Disease, 2011
Background Inflammation has been implicated in a variety of diseases associated with ageing, including cancer, cardiovascular, and neurologic diseases.
Papasian Christopher J, Badr Mostafa Z, Reis Julia C, Tan Xiaoyu, Qureshi Asaf A, Morrison David C, Qureshi Nilofer   +6 more
doaj   +1 more source

Comparison of expression of genes coding for β-catenin (CTNNB1) (A), CacyBP/SIP (B), galectin-3 (LGALS3) (C) and LMP7 (PSMB8) (D) in the heart of men at different age.

, 2020
Comparison of expression of genes coding for β-catenin (CTNNB1) (A), CacyBP/SIP (B), galectin-3 (LGALS3) (C) and LMP7 (PSMB8) (D) in the heart of men at different age.
Irena Kasacka (8520003), Wojciech Łebkowski (8520015), Żaneta Piotrowska (8520006), Alicja Lewandowska (8520012), Michał Niezgoda (8520009)   +4 more
core   +1 more source

Analysis of MHC class I cell surface expression in lmp7^−/− Mefs expressing proLMP7- or proβ5-containing subunits.

, 2012
lmp7−/− Mefs expressing LMP7-Flag, proLMP7mβ5-Flag, β5-Flag, proβ5mLMP7-Flag or cells transduced with the empty vector construct were cultured in the presence of 50 U/ml IFNγ for 4 days.
Nicole Schmidt (154421), Ulrich Steinhoff (154431), Stefan H. E. Kaufmann (149315), Petra Krienke (154424), Alexander Visekruna (154426), Ulrike Kuckelkorn (154428), David Ermert (154423), Thorsten Joeris (154419)   +7 more
core   +1 more source

IRF‐1 mediates upregulation of LMP7 by IFN‐γ and concerted expression of immunosubunits of the proteasome

FEBS Letters, 2005
An immunoproteasome subunit low molecular weight protein 7 (LMP7) plays critical roles in major histocompatibility complex class I antigen processing; however, the mechanism for its expression has remained unclear. We demonstrate that interferon (IFN) regulatory factor‐1 (IRF‐1) has a pivotal role in IFN‐γ‐dependent LMP7 expression, as was shown for ...
Namiki, Shin, Nakamura, Tetsuya, Oshima, Shigeru, Yamazaki, Motomi, Sekine, Yuko, Tsuchiya, Kiichiro, Okamoto, Ryuichi, Kanai, Takanori, Watanabe, Mamoru   +8 more
openaire   +2 more sources

Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic cat.

PLoS ONE, 2008
Two sequences of major histocompatibility complex (MHC) regions in the domestic cat, 2.976 and 0.362 Mbps, which were separated by an ancient chromosome break (55-80 MYA) and followed by a chromosomal inversion were annotated in detail.
Naoya Yuhki, James C Mullikin, Thomas Beck, Robert Stephens, Stephen J O'Brien   +4 more
doaj   +1 more source

Susceptibility of RBCs from LMP7-deficient mice infected with PyL to phagocytosis by macrophages.

, 2013
(A) Peritoneal macrophages obtained from WT mice were cultured with CFSE-labeled nRBCs and pRBCs prepared from WT or LMP7-deficient mice as in Fig. 3B. Phagocytosing macrophages were determined as in Fig. 3B.
Makoto Hirai (227542), Hiroko Okada (391891), Hajime Hisaeda (391893), Liping Tu (391888), Kazutomo Suzue (115420), Bin Chou (391887), Chikako Shimokawa (391892), Tomoyo Taniguchi (391890), Takashi Imai (24800), Kunisuke Himeno (391889), Xuefeng Duan (391886)   +10 more
core   +1 more source

Inhibition of Immunoproteasome Attenuates NLRP3 Inflammasome Response by Regulating E3 Ubiquitin Ligase TRIM31

Cells
Excessive secretion of pro-inflammatory cytokines leads to the disruption of intestinal barrier in inflammatory bowel disease (IBD). The inflammatory cytokine tumor necrosis factor alpha (TNFα) induces the assembly of the NLRP3 inflammasome, resulting in
Yubin Lee, Boran Yoon, Sumin Son, Eunbin Cho, Kyung Bo Kim, Eun Young Choi, Dong-Eun Kim   +6 more
doaj   +1 more source

EXPRESSION OF GENES ENCODING IMMUNOPROTEASOME SUBUNITS INDUCIBLE BY MACROPHAGES INFECTED WITH M. bovis BGC AND M. Tuberculosis H37RV

Туберкулез и болезни лёгких, 2014
To study the effect of M. bovis BCG vaccine strain and virulent laboratory M. tuberculosis H37Rv strain on the expression of macrophageinducible immunoproteasome subunits, a real-time reverse-transcription polymerase chain reaction technique using cDNA ...
S. N. Andreevskaya, T. G. Smirnova, A. V. Timofeev, E. E. Larionova, L. N. Chernousova   +4 more
doaj  

MRI-based machine learning reveals proteasome subunit PSMB8-mediated malignant glioma phenotypes through activating TGFBR1/2-SMAD2/3 axis

Molecular Biomedicine
Gliomas are the most prevalent and aggressive neoplasms of the central nervous system, representing a major challenge for effective treatment and patient prognosis.
Dongling Pei, Zeyu Ma, Yuning Qiu, Minkai Wang, Zilong Wang, Xianzhi Liu, Long Zhang, Zhenyu Zhang, Ran Li, Dongming Yan   +9 more
doaj   +1 more source