Results 111 to 120 of about 2,423 (198)

LMP2 ve LMP7 genlerinin obezite ile ı̇lişkisinin ı̇ncelenmesi

, 2020
67
openaire   +1 more source

CD8+T-cell auto-reactivity is dependent on the expression of the immunoproteasome subunit LMP7 in exposed to lipopolysaccharide antigen presenting cells and epithelial target cells

, 2013
Proteasome generates peptides for presentation to CD8+ T-cells by antigen presenting cells (APCs) and peripheral cells. Inflammation alters proteasome to immunoproteasome, producing a different pool of peptides.
Pissas, G., Stefanidis, I., Eleftheriadis, T., Liakopoulos, V., Antoniadi, G.   +4 more
core   +1 more source

Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.

, 2016
Generation of the HLA-A0201 (A2) influenza Matrix 58-66 epitope contained within the full-length Matrix protein is impaired in cells lacking the proteasome subunits low molecular protein 2 (LMP2) and LMP7.

core  

LY2874455 promoted the degradation of immunoproteasomes through autophagy and selective receptor p62.

(A) Autophagy deficiency caused increased levels of immunoproteasome subunits. Protein levels of LMP2, LMP7, and GAPDH were detected by western blot in WT or ATG7 knock out (ATG7-KO, through CRISPR-CAS9 method) RAW264.7 cells.
Gaoyue Jiang (18115410), Shanze Chen (3524258), Kefeng Lu (9282707), Meng Lu (271376), Huihui Li (227521), Jiao Zhou (2937987), Chunxia Li (182841)   +6 more
core   +1 more source

Vrednotenje substituiranih psoralenov kot zaviralcev LMP7 podenote imunoprotesoma

, 2016
Proteasom je multikatalitični kompleks, ki homeostazo celice vzdržuje preko odstranjevanja nepravilno zvitih in poškodovanih proteinov ter drugih signalnih molekul, ki nastanejo tekom različnih celičnih procesov. Preoteasom obstaja v več oblikah, a sta med pomembnejšimi standardni in imunoproteasom.
openaire   +1 more source

ONX-0914 Suppresses Hormone-Sensitive Prostate Cancer by Promoting O-GlcNAcylation-Mediated Stabilization of TCF7L1. [PDF]

Oncol Res
Xian P, Feng Z, Yu H, Yin H, Chen H, Shi T, Li X, Zhang C, Bai X, Gou X, Li X, Li J.   +11 more
europepmc   +1 more source

The immunoproteasome as a neuroimmune hub in the central nervous system: from proteostasis stress to inflammatory pathology. [PDF]

J Neuroinflammation
Zhao H, Liu Y, Chen X.
europepmc   +1 more source

Immunoproteasomes in Skeletal Muscle Pathologies: Emerging Roles, Conflicting Evidence, and Future Directions. [PDF]

Cells
Kalinkovich A, Livshits G.
europepmc   +1 more source

Antigen processing machinery deficits in head and neck cancers: mechanisms of immune evasion and strategies for therapeutic restoration. [PDF]

Front Oncol
Iyer P, Kinney BLC, Brammer B, Lee MY, Rosenthal JW, Schmitt NC.   +5 more
europepmc   +1 more source

The role of immunoproteasome in diabetes and diabetes-related complications. [PDF]

Genes Dis
Wang M, Luo L, Dai L, Zeng H, Wang H.
europepmc   +1 more source