Results 131 to 140 of about 1,819 (163)

Up-regulation of the proteasome subunit LMP7 in tissues of endotoxemic rats

Journal of Laboratory and Clinical Medicine, 2000
The proteasome has been implicated in systemic responses to infection or inflammatory stimuli including catabolism of skeletal muscle. Cytokines including tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) are known to be elevated systemically and locally under these conditions.
J E, Nelson, A, Loukissa, C, Altschuller-Felberg, J J, Monaco, J T, Fallon, C, Cardozo   +5 more
openaire   +2 more sources

Genetic polymorphism in intron 6 of the LMP7 gene in Japanese and its association with sarcoidosis

Tissue Antigens, 1997
Genetic polymorphism in intron 6 of the LMP7 gene was investigated using polymerase chain reaction‐restriction fragment length polymorphism in 90 unrelated healthy Japanese controls and 66 Japanese patients with sarcoidosis. Four alleles, including two new ones recently identified in Koreans, LMP7*C and LMP7*D, were found in the Japanese population ...
T Naruse
exaly   +3 more sources

Pig Lmp7 proteasome subunit cDNA cloning and expression analysis

Immunogenetics, 1999
Received: 15 May 1998 / Revised: 23 June 1998The nucleotide sequence data reported in this paper have beensubmitted to the GenBank nucleotide sequence database andhave been assigned the number AF059493H. R. Gaskins (Y)University of Illinois at Urbana-Champaign,1207 W. Gregory Drive, Urbana, IL 61801, USAT. Chun 7 H. R.
T, Chun, E, Hermel, C J, Aldrich, H R, Gaskins   +3 more
openaire   +2 more sources

Genetic linkage between the LMP2 and LMP7 genes in the medaka fish, a teleost

Immunogenetics, 1997
Kiyoshi Naruse, Akihiro Shima, Noriyuki Kuroda   +2 more
exaly   +3 more sources

Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis

Cardiovascular Research, 2022
Abstract Aims The loss of vascular wall cells in allotransplanted arteries is the initial event leading to transplant arteriosclerosis (TA) and ensuing loss of allograft function. Pharmacological agents able to prevent TA are currently lacking.
Jun Li, Shaobo Hu, Henry W B Johnson, Christopher J Kirk, Peng Xian, Yanping Song, Yuan Li, Nan Liu, Marcus Groettrup, Michael Basler   +9 more
openaire   +2 more sources

Association analysis of polymorphisms of porcine LMP2 and LMP7 genes with haematological traits

Molecular Biology Reports, 2010
Low molecular weight polypeptides 2 (LMP2) and low molecular weight polypeptides 7 (LMP7) are located within the major histocompatibility complex and have been associated with autoimmune disease. In this study, polymorphisms of porcine LMP2 and LMP7 genes were analyzed by PCR-SSCP and DNA sequencing methods.
Y, Liu, Y R, Luo, X, Lu, X T, Qiu, J P, Zhou, Y F, Gong, X D, Ding, Q, Zhang   +7 more
openaire   +2 more sources

Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm

Biochemical and Biophysical Research Communications, 2020
Macrophages contribute to abdominal aortic aneurysm (AAA), but the effect of macrophage on AAA formation is not totally understood. Recent research proved that macrophage pyroptosis plays an important role in many cardiovascular disease. However, whether macrophage pyroptosis is involved in AAA and its mechanism remains unknown. In this study, we found
Xu, Zhang, Fangda, Li, Wei, Wang, Lei, Ji, Bo, Sun, Xue, Xiao, Xiaoxiao, Wang, Yuexin, Chen, Bao, Liu, Wei, Ye, Cui, Tian, Hongxia, Wang, Yuehong, Zheng   +12 more
openaire   +2 more sources

CONTROL OF LMP7 EXPRESSION IN HUMAN ENDOTHELIAL CELLS BY CYTOKINES REGULATING CELLULAR AND HUMORAL IMMUNITY

Cytokine, 2000
Formation of antigenic peptides by the multicatalytic proteinase complex (MPC, proteasome) is facilitated by incorporation of three subunits (LMP2, LMP7 and LMP10) that are inducible by IFN-gamma and TNF-alpha. These cytokines, or their functional homologues (e.g. TNF-beta), are released from many cells including Th(1)lymphocytes.
Christopher P Cardozo
exaly   +3 more sources

Genetic polymorphism of the mouse major histocompatibility complex-associated proteasome subunit Lmp7

Immunogenetics, 1995
Major histocompatibility complex (MHC) class I molecules mainly resent antigenic peptides derived from cytosolic and nucleic proteins. The discovery of four new genes, namely Tap1, Tap2, Lmp2, and Lmp7, in the human, mouse, and rat MHC class II regions has shed light on the mechanisms repsonsible for the production and transport of these antigenic ...
E, Zanelli, P, Zhou, H, Cao, M K, Smart, C S, David   +4 more
openaire   +2 more sources

Polymorphism in the LMP2 and LMP7 genes and adult rheumatoid arthritis: no relationship with disease susceptibility or outcome

Tissue Antigens, 1995
Walter P Maksymowych, F Pazderka
exaly   +3 more sources