Results 161 to 170 of about 2,423 (198)

A Selective Inhibitor of the Immunoproteasome Subunit LMP7 Blocks Cytokine Production and Attenuates Progression of Experimental Arthritis

Nature Medicine, 2009
The immunoproteasome, a distinct class of proteasome found predominantly in monocytes and lymphocytes, is known to shape the antigenic repertoire presented on class I major histocompatibility complexes (MHC-I).
Marcus Gröttrup, Michael Basler, Tony Muchamuel   +2 more
exaly   +2 more sources

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No independent associations of LMP2 and LMP7 polymorphisms with susceptibility to develop IDDM

Diabetes, 1997
Results from a recent study suggested that polymorphisms within the HLA class II genes LMP2 and LMP7 were associated with the susceptibility for developing IDDM, and that this association could not be explained by linkage disequilibrium to HLA-DR or -DQ genes.
D E, Undlien, H E, Akselsen, G, Joner, K, Dahl-Jørgensen, O, Søvik, K S, Rønningen, E, Thorsby   +6 more
openaire   +2 more sources

LMP7 polymorphism in Japanese patients with sarcoidosis and Behçet's disease

Human Immunology, 1996
To evaluate the influence of the MHC-linked LMP7 gene on disease susceptibility in HLA class I and class II-associated diseases, the distribution of LMP7 alleles was determined using the PCR-RFLP method in 69 Japanese patients with Behçet's disease, 65 patients with sarcoidosis, and 100 unrelated healthy controls.
M, Ishihara, S, Ohno, N, Mizuki, N, Yamagata, T, Ishida, T, Naruse, A, Ando, H, Inoko   +7 more
openaire   +2 more sources

Divergent intron arrangement in theMB1/LMP7 proteasome gene pair

Immunogenetics, 1996
We sequenced the human MB1 gene from a cosmid clone mapping to chromosome 14q11.2-12. The gene spans about 6 kilobases and contains three exons and two introns. There was no evidence of an alternative leader exon, which is a characteristic of the major histocompatibility complex (MHC)-encoded LMP7 gene, the closest relative of MB1, with which it shares
S, Abdulla, S, Beck, M, Belich, A, Jackson, T, Nakamura, J, Trowsdale   +5 more
openaire   +2 more sources

LMP2 And LMP7 Gene Polymorphisms in the Southeastern Anatolia Population of Turkey

International Journal of Human Genetics, 2013
The low molecular weight polypeptide 2 (LMP2) and low molecular weight polypeptide 7 (LMP7) genes are located in the class II region of the Major Histocompatability Complex (MHC) locus on chromosome 6. These genes encode peptides forming the large components of the proteosome complex which degrades short-lived cytoplasmic proteins.
Filiz Özbaş Gerçeker
exaly   +2 more sources

Pig Lmp7 proteasome subunit cDNA cloning and expression analysis

Immunogenetics, 1999
Received: 15 May 1998 / Revised: 23 June 1998The nucleotide sequence data reported in this paper have beensubmitted to the GenBank nucleotide sequence database andhave been assigned the number AF059493H. R. Gaskins (Y)University of Illinois at Urbana-Champaign,1207 W. Gregory Drive, Urbana, IL 61801, USAT. Chun 7 H. R.
T, Chun, E, Hermel, C J, Aldrich, H R, Gaskins   +3 more
openaire   +2 more sources

Genetic Polymorphism in Intron 6 of the LMP7 Gene in Japanese and Its Association With Sarcoidosis

Tissue Antigens, 1997
Genetic polymorphism in intron 6 of the LMP7 gene was investigated using polymerase chain reaction‐restriction fragment length polymorphism in 90 unrelated healthy Japanese controls and 66 Japanese patients with sarcoidosis. Four alleles, including two new ones recently identified in Koreans, LMP7*C and LMP7*D, were found in the Japanese population ...
T Naruse, H Inoko
exaly   +3 more sources

Up-regulation of the proteasome subunit LMP7 in tissues of endotoxemic rats

Journal of Laboratory and Clinical Medicine, 2000
The proteasome has been implicated in systemic responses to infection or inflammatory stimuli including catabolism of skeletal muscle. Cytokines including tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) are known to be elevated systemically and locally under these conditions.
J E, Nelson, A, Loukissa, C, Altschuller-Felberg, J J, Monaco, J T, Fallon, C, Cardozo   +5 more
openaire   +2 more sources

Genetic Linkage Between the LMP2 and LMP7 Genes in the Medaka Fish, a Teleost

Immunogenetics, 1997
Kiyoshi Naruse, Noriyuki KURODA, Akihiro Shima   +2 more
exaly   +3 more sources

Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm

Biochemical and Biophysical Research Communications, 2020
Macrophages contribute to abdominal aortic aneurysm (AAA), but the effect of macrophage on AAA formation is not totally understood. Recent research proved that macrophage pyroptosis plays an important role in many cardiovascular disease. However, whether macrophage pyroptosis is involved in AAA and its mechanism remains unknown. In this study, we found
Xu, Zhang, Fangda, Li, Wei, Wang, Lei, Ji, Bo, Sun, Xue, Xiao, Xiaoxiao, Wang, Yuexin, Chen, Bao, Liu, Wei, Ye, Cui, Tian, Hongxia, Wang, Yuehong, Zheng   +12 more
openaire   +2 more sources