Results 161 to 170 of about 2,385 (193)

Pig Lmp7 proteasome subunit cDNA cloning and expression analysis

Immunogenetics, 1999
Received: 15 May 1998 / Revised: 23 June 1998The nucleotide sequence data reported in this paper have beensubmitted to the GenBank nucleotide sequence database andhave been assigned the number AF059493H. R. Gaskins (Y)University of Illinois at Urbana-Champaign,1207 W. Gregory Drive, Urbana, IL 61801, USAT. Chun 7 H. R.
T, Chun, E, Hermel, C J, Aldrich, H R, Gaskins   +3 more
openaire   +2 more sources

Genetic linkage between the LMP2 and LMP7 genes in the medaka fish, a teleost

Immunogenetics, 1997
Kiyoshi Naruse, Noriyuki Kuroda, Makoto Sasaki   +2 more
exaly   +3 more sources

Up-regulation of the proteasome subunit LMP7 in tissues of endotoxemic rats

Journal of Laboratory and Clinical Medicine, 2000
The proteasome has been implicated in systemic responses to infection or inflammatory stimuli including catabolism of skeletal muscle. Cytokines including tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) are known to be elevated systemically and locally under these conditions.
J E, Nelson, A, Loukissa, C, Altschuller-Felberg, J J, Monaco, J T, Fallon, C, Cardozo   +5 more
openaire   +2 more sources

Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm

Biochemical and Biophysical Research Communications, 2020
Macrophages contribute to abdominal aortic aneurysm (AAA), but the effect of macrophage on AAA formation is not totally understood. Recent research proved that macrophage pyroptosis plays an important role in many cardiovascular disease. However, whether macrophage pyroptosis is involved in AAA and its mechanism remains unknown. In this study, we found
Xu, Zhang, Fangda, Li, Wei, Wang, Lei, Ji, Bo, Sun, Xue, Xiao, Xiaoxiao, Wang, Yuexin, Chen, Bao, Liu, Wei, Ye, Cui, Tian, Hongxia, Wang, Yuehong, Zheng   +12 more
openaire   +2 more sources

Association analysis of polymorphisms of porcine LMP2 and LMP7 genes with haematological traits

Molecular Biology Reports, 2010
Low molecular weight polypeptides 2 (LMP2) and low molecular weight polypeptides 7 (LMP7) are located within the major histocompatibility complex and have been associated with autoimmune disease. In this study, polymorphisms of porcine LMP2 and LMP7 genes were analyzed by PCR-SSCP and DNA sequencing methods.
Y, Liu, Y R, Luo, X, Lu, X T, Qiu, J P, Zhou, Y F, Gong, X D, Ding, Q, Zhang   +7 more
openaire   +2 more sources

CD8+ T-cell auto-reactivity is dependent on the expression of the immunoproteasome subunit LMP7 in exposed to lipopolysaccharide antigen presenting cells and epithelial target cells

Autoimmunity, 2013
Proteasome generates peptides for presentation to CD8+ T-cells by antigen presenting cells (APCs) and peripheral cells. Inflammation alters proteasome to immunoproteasome, producing a different pool of peptides.
Georgios Pissas, Theodoros Eleftheriadis, Ioannis Stefanidis   +2 more
exaly   +2 more sources

Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i)

Journal of Medicinal Chemistry, 2021
Proteasomes are broadly expressed key components of the ubiquitin-dependent protein degradation pathway containing catalytically active subunits (β1, β2, and β5). LMP7 (β5i) is a subunit of the immunoproteasome, an inducible isoform that is predominantly expressed in hematopoietic cells.
Markus Klein, Michael Busch, Manja Friese-Hamim, Stefano Crosignani, Thomas Fuchss, Djordje Musil, Felix Rohdich, Michael P. Sanderson, Jeyaprakashnarayanan Seenisamy, Gina Walter-Bausch, Ugo Zanelli, Philip Hewitt, Christina Esdar, Oliver Schadt   +13 more
openaire   +2 more sources

Genetic polymorphism in intron 6 of the LMP7 gene in Japanese and its association with sarcoidosis

Tissue Antigens, 1997
Genetic polymorphism in intron 6 of the LMP7 gene was investigated using polymerase chain reaction‐restriction fragment length polymorphism in 90 unrelated healthy Japanese controls and 66 Japanese patients with sarcoidosis. Four alleles, including two new ones recently identified in Koreans, LMP7*C and LMP7*D, were found in the Japanese population ...
M, Ishihara, S, Ohno, T, Ishida, T, Naruse, H, Inoko   +4 more
exaly   +3 more sources

Genetic polymorphism of the mouse major histocompatibility complex-associated proteasome subunit Lmp7

Immunogenetics, 1995
Major histocompatibility complex (MHC) class I molecules mainly resent antigenic peptides derived from cytosolic and nucleic proteins. The discovery of four new genes, namely Tap1, Tap2, Lmp2, and Lmp7, in the human, mouse, and rat MHC class II regions has shed light on the mechanisms repsonsible for the production and transport of these antigenic ...
E, Zanelli, P, Zhou, H, Cao, M K, Smart, C S, David   +4 more
openaire   +2 more sources

Immunoproteasome subunits LMP2 and LMP7 downregulation in primary malignant melanoma lesions

Melanoma Research, 2003
Recently, expression of the immunoproteasome subunits low molecular protein (LMP) 2 or LMP7 was shown to reduce the presentation of certain major histocompatibility complex (MHC) class I-restricted tumour peptide epitopes in renal cell carcinoma and melanoma cells. This may provide the tumour cells with an immune escape mechanism. To test the relevance
Joachim, Dissemond, Petra, Goette, Janet, Moers, Anette, Lindeke, Manfred, Goos, Soldano, Ferrone, Stephan N, Wagner   +6 more
openaire   +2 more sources