Results 151 to 160 of about 2,385 (193)

Immunoproteasome deficiency results in age-dependent development of epilepsy. [PDF]

Brain Commun
Leister H, Krause FF, Gil B, Prus R, Prus I, Hellhund-Zingel A, Mitra M, Da Rosa Gerbatin R, Delanty N, Beausang A, Brett FM, Farrell MA, Cryan J, O'Brien DF, Henshall DC, Helmprobst F, Pagenstecher A, Steinhoff U, Visekruna A, Engel T.   +19 more
europepmc   +1 more source

Imaging antigen processing and presentation in cancer. [PDF]

Immunother Adv
Lau D, Elliott T.
europepmc   +1 more source

Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice. [PDF]

Arterioscler Thromb Vasc Biol
Schaftenaar FH, van Dam AD, de Bruin G, Depuydt MAC, de Mol J, Amersfoort J, Douna H, Meijer M, Kröner MJ, van Santbrink PJ, Bernabé Kleijn MNA, van Puijvelde GHM, Florea BI, Slütter B, Foks AC, Bot I, Rensen PCN, Kuiper J.   +17 more
europepmc   +1 more source

Protocol for isolating human extracellular vesicles from nephrotic urine and enriching autoimmunoglobulin-triggered extracellular vesicles. [PDF]

STAR Protoc
Lahme K, Meyer-Schwesinger C.
europepmc   +1 more source

Immunohistochemical Identification and Assessment of the Location of Immunoproteasome Subunits LMP2 and LMP7 in Acquired Cholesteatoma

International Journal of Molecular Sciences, 2023
Cholesteatoma, accompanied by chronic inflammatory response, is characterized by invasive growth and osteolytic activity. As specific proteasome isoforms, the immunoproteasomes serve as an important modulator of inflammatory responses. The aim of the present study was to determine the biological activity of cholesteatoma through the analysis of the ...
Ewa Olszewska, Irena Kasacka, Marek Rogowski   +2 more
exaly   +4 more sources

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LMP7 inhibits the activation of NLRP3 inflammasome through interaction with NLRP3

Biochemical and Biophysical Research Communications, 2020
The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) by coding pattern recognition receptors (PRRs). As a well-known inflammasome, NLRP3 plays an essential role in helping the host immune response and driving antiviral processes.
Kailang Wu, Jing Jin, Aixin Li
exaly   +3 more sources

20S proteasome from LMP7 knock out mice reveals altered proteolytic activities and cleavage site preferences [PDF]

FEBS Letters, 1996
20S proteasomes of tissues from LMP7 knock out mice which show reduced MHC class I restricted antigen presentation were analyzed with regard to their subunit composition, peptide hydrolyzing activity and their ability to cleave a synthetic 25-mer ...
Peter M Kloetzel
exaly   +2 more sources

No independent associations of LMP2 and LMP7 polymorphisms with susceptibility to develop IDDM

Diabetes, 1997
Results from a recent study suggested that polymorphisms within the HLA class II genes LMP2 and LMP7 were associated with the susceptibility for developing IDDM, and that this association could not be explained by linkage disequilibrium to HLA-DR or -DQ genes.
D E, Undlien, H E, Akselsen, G, Joner, K, Dahl-Jørgensen, O, Søvik, K S, Rønningen, E, Thorsby   +6 more
openaire   +2 more sources

LMP7 polymorphism in Japanese patients with sarcoidosis and Behçet's disease

Human Immunology, 1996
To evaluate the influence of the MHC-linked LMP7 gene on disease susceptibility in HLA class I and class II-associated diseases, the distribution of LMP7 alleles was determined using the PCR-RFLP method in 69 Japanese patients with Behçet's disease, 65 patients with sarcoidosis, and 100 unrelated healthy controls.
M, Ishihara, S, Ohno, N, Mizuki, N, Yamagata, T, Ishida, T, Naruse, A, Ando, H, Inoko   +7 more
openaire   +2 more sources

Divergent intron arrangement in theMB1/LMP7 proteasome gene pair

Immunogenetics, 1996
We sequenced the human MB1 gene from a cosmid clone mapping to chromosome 14q11.2-12. The gene spans about 6 kilobases and contains three exons and two introns. There was no evidence of an alternative leader exon, which is a characteristic of the major histocompatibility complex (MHC)-encoded LMP7 gene, the closest relative of MB1, with which it shares
S, Abdulla, S, Beck, M, Belich, A, Jackson, T, Nakamura, J, Trowsdale   +5 more
openaire   +2 more sources