Results 171 to 180 of about 2,423 (198)

Association analysis of polymorphisms of porcine LMP2 and LMP7 genes with haematological traits

Molecular Biology Reports, 2010
Low molecular weight polypeptides 2 (LMP2) and low molecular weight polypeptides 7 (LMP7) are located within the major histocompatibility complex and have been associated with autoimmune disease. In this study, polymorphisms of porcine LMP2 and LMP7 genes were analyzed by PCR-SSCP and DNA sequencing methods.
Y, Liu, Y R, Luo, X, Lu, X T, Qiu, J P, Zhou, Y F, Gong, X D, Ding, Q, Zhang   +7 more
openaire   +2 more sources

Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i)

Journal of Medicinal Chemistry, 2021
Proteasomes are broadly expressed key components of the ubiquitin-dependent protein degradation pathway containing catalytically active subunits (β1, β2, and β5). LMP7 (β5i) is a subunit of the immunoproteasome, an inducible isoform that is predominantly expressed in hematopoietic cells.
Markus Klein, Michael Busch, Manja Friese-Hamim, Stefano Crosignani, Thomas Fuchss, Djordje Musil, Felix Rohdich, Michael P. Sanderson, Jeyaprakashnarayanan Seenisamy, Gina Walter-Bausch, Ugo Zanelli, Philip Hewitt, Christina Esdar, Oliver Schadt   +13 more
openaire   +2 more sources

Genetic polymorphism of the mouse major histocompatibility complex-associated proteasome subunit Lmp7

Immunogenetics, 1995
Major histocompatibility complex (MHC) class I molecules mainly resent antigenic peptides derived from cytosolic and nucleic proteins. The discovery of four new genes, namely Tap1, Tap2, Lmp2, and Lmp7, in the human, mouse, and rat MHC class II regions has shed light on the mechanisms repsonsible for the production and transport of these antigenic ...
E, Zanelli, P, Zhou, H, Cao, M K, Smart, C S, David   +4 more
openaire   +2 more sources

Immunoproteasome subunits LMP2 and LMP7 downregulation in primary malignant melanoma lesions

Melanoma Research, 2003
Recently, expression of the immunoproteasome subunits low molecular protein (LMP) 2 or LMP7 was shown to reduce the presentation of certain major histocompatibility complex (MHC) class I-restricted tumour peptide epitopes in renal cell carcinoma and melanoma cells. This may provide the tumour cells with an immune escape mechanism. To test the relevance
Joachim, Dissemond, Petra, Goette, Janet, Moers, Anette, Lindeke, Manfred, Goos, Soldano, Ferrone, Stephan N, Wagner   +6 more
openaire   +2 more sources

[Involvement of TAP2 and LMP7 gene polymorphisms in HCV infection].

Nihon rinsho. Japanese journal of clinical medicine, 2001
We aimed to study whether TAP and LMP polymorphisms could influence the severity of liver disease or the response to IFN treatment in patients with chronic HCV infection. TAPZ*0103 gene frequencies in carriers with normal ALT was significantly higher than that in CLD patients.
N, Kuzushita, Y, Sugimoto, Y, Sasaki, N, Hayashi   +3 more
openaire   +1 more source

Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection

European Journal of Immunology, 2009
AbstractProteasome‐mediated proteolysis is responsible for the generation of immunogenic epitopes presented by MHC class I molecules, which activate antigen‐specific CD8+ T cells. Immunoproteasomes, defined by the presence of the three catalytic subunits LMP2, MECL‐1, and LMP7, have been hypothesized to optimize MHC class I antigen processing.
Liping, Tu, Chikako, Moriya, Takashi, Imai, Hidekazu, Ishida, Kohhei, Tetsutani, Xuefeng, Duan, Shigeo, Murata, Keiji, Tanaka, Chikako, Shimokawa, Hajime, Hisaeda, Kunisuke, Himeno   +10 more
openaire   +2 more sources

Development and characterization of mouse anti‐human LMP2, LMP7, TAP1 and TAP2 monoclonal antibodies

Tissue Antigens, 1998
Abstract: Low molecular mass polypeptides (LMP) 2 and LMP7 and transporter associated with antigen processing (TAP) subunits TAP1 and TAP2 play a crucial role in antigen processing and cell surface expression of HLA class I molecules. Since monoclonal antibodies (mAb) to these molecules will facilitate the analysis of their expression, structure and ...
R, Kishore, D J, Hicklin, D V, Dellaratta, U, Golde, T, Kageshita, B, Seliger, S, Ferrone   +6 more
openaire   +2 more sources

Lentinan alleviates angiotensin II-induced myocardial remodeling through LMP7-SOCS3 signaling

International Journal of Biological Macromolecules
Myocardial remodeling is a major pathological mechanism causing heart failure. As a critical negative modulator of cardiac remodeling, suppressor of cytokine signaling 3 (SOCS3) is regulated by immunoproteasome subunit large multifunctional peptidase 7 (LMP7).
Yu, Pan, Bingqi, Chen, Jiawen, Xie, Danni, Chen, Yuwei, Cai, Denghui, Zhao, Yifei, Cao, Fuzhi, Lian, Xiao, Yan   +8 more
openaire   +2 more sources

[The relationship between polymorphism of LMP2 and LMP7 genes and the phenotype of ankylosing spondylitis].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 1999
To evaluate the relationship of the polymorphism of LMP2 and LMP7 genes and the phenotype of patients with ankylosing spondylitis(AS).One hundred and eighteen blood samples were collected from patients with AS and acute anterior uveitis(AAU). HLA-B(27) typing was performed and LMP2 and LMP7 amplified fragment length polymorphisms were determined after ...
H, Ding, H, Lu, D, Jiang, Z, Chen, J, Lin, S, Wang   +5 more
openaire   +1 more source

Cellular distribution of proteasome subunit Lmp7 mRNA and protein in human placentas.

Immunology, 1996
Human leucocyte antigen (HLA) class I antigen expression is closely controlled in placental trophoblast cells, which interface directly with genetically disparate maternal blood and tissues during pregnancy. In this study, the possibility that LMP7, a proteasome component that may be required for processing of class I-associated peptides, might be ...
K F, Roby, Y, Yang, D, Gershon, J S, Hunt   +3 more
openaire   +1 more source