Results 171 to 180 of about 2,385 (193)

[Involvement of TAP2 and LMP7 gene polymorphisms in HCV infection].

Nihon rinsho. Japanese journal of clinical medicine, 2001
We aimed to study whether TAP and LMP polymorphisms could influence the severity of liver disease or the response to IFN treatment in patients with chronic HCV infection. TAPZ*0103 gene frequencies in carriers with normal ALT was significantly higher than that in CLD patients.
N, Kuzushita, Y, Sugimoto, Y, Sasaki, N, Hayashi   +3 more
openaire   +1 more source

Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection

European Journal of Immunology, 2009
AbstractProteasome‐mediated proteolysis is responsible for the generation of immunogenic epitopes presented by MHC class I molecules, which activate antigen‐specific CD8+ T cells. Immunoproteasomes, defined by the presence of the three catalytic subunits LMP2, MECL‐1, and LMP7, have been hypothesized to optimize MHC class I antigen processing.
Liping, Tu, Chikako, Moriya, Takashi, Imai, Hidekazu, Ishida, Kohhei, Tetsutani, Xuefeng, Duan, Shigeo, Murata, Keiji, Tanaka, Chikako, Shimokawa, Hajime, Hisaeda, Kunisuke, Himeno   +10 more
openaire   +2 more sources

Development and characterization of mouse anti‐human LMP2, LMP7, TAP1 and TAP2 monoclonal antibodies

Tissue Antigens, 1998
Abstract: Low molecular mass polypeptides (LMP) 2 and LMP7 and transporter associated with antigen processing (TAP) subunits TAP1 and TAP2 play a crucial role in antigen processing and cell surface expression of HLA class I molecules. Since monoclonal antibodies (mAb) to these molecules will facilitate the analysis of their expression, structure and ...
R, Kishore, D J, Hicklin, D V, Dellaratta, U, Golde, T, Kageshita, B, Seliger, S, Ferrone   +6 more
openaire   +2 more sources

Lentinan alleviates angiotensin II-induced myocardial remodeling through LMP7-SOCS3 signaling

International Journal of Biological Macromolecules
Myocardial remodeling is a major pathological mechanism causing heart failure. As a critical negative modulator of cardiac remodeling, suppressor of cytokine signaling 3 (SOCS3) is regulated by immunoproteasome subunit large multifunctional peptidase 7 (LMP7).
Yu, Pan, Bingqi, Chen, Jiawen, Xie, Danni, Chen, Yuwei, Cai, Denghui, Zhao, Yifei, Cao, Fuzhi, Lian, Xiao, Yan   +8 more
openaire   +2 more sources

[The relationship between polymorphism of LMP2 and LMP7 genes and the phenotype of ankylosing spondylitis].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 1999
To evaluate the relationship of the polymorphism of LMP2 and LMP7 genes and the phenotype of patients with ankylosing spondylitis(AS).One hundred and eighteen blood samples were collected from patients with AS and acute anterior uveitis(AAU). HLA-B(27) typing was performed and LMP2 and LMP7 amplified fragment length polymorphisms were determined after ...
H, Ding, H, Lu, D, Jiang, Z, Chen, J, Lin, S, Wang   +5 more
openaire   +1 more source

Cellular distribution of proteasome subunit Lmp7 mRNA and protein in human placentas.

Immunology, 1996
Human leucocyte antigen (HLA) class I antigen expression is closely controlled in placental trophoblast cells, which interface directly with genetically disparate maternal blood and tissues during pregnancy. In this study, the possibility that LMP7, a proteasome component that may be required for processing of class I-associated peptides, might be ...
K F, Roby, Y, Yang, D, Gershon, J S, Hunt   +3 more
openaire   +1 more source

Emodin alleviates high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation of mesangial cells by the circ_0000064/miR-30c-5p/Lmp7 axis

Journal of Receptor and Signal Transduction Research, 2022
Yanquan Han
exaly  

miR-451 suppresses the NF-kappaB-mediated proinflammatory molecules expression through inhibiting LMP7 in diabetic nephropathy

Molecular and Cellular Endocrinology, 2016
Handeng Liu, Zheng Zhang, Yan Sun
exaly  

Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(β5i) incorporation into 20 S proteasomes 1 1Edited by R. Huber

Journal of Molecular Biology, 2000
Elke Krueger, Peter M Kloetzel, Peter-M Kloetzel   +2 more
exaly  

Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV‐induced meningitis

European Journal of Immunology, 2016
Marcus Groettrup, Michael Basler, Sarah Mundt   +2 more
exaly