Results 1 to 10 of about 4,413 (167)

Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia [PDF]

Frontiers in Immunology, 2021
The immunoproteasome, a special isoform of the 20S proteasome, is expressed when the cells receive an inflammatory signal. Immunoproteasome inhibition proved efficacy in the treatment of autoimmune diseases.
Ming Hou, Miao Xu
exaly   +5 more sources

Immunoproteasome components LMP2, PSME1, and PSME2 as novel tissue biomarkers predicting response and survival in neoadjuvant chemoimmunotherapy for resectable NSCLC [PDF]

Frontiers in Immunology
BackgroundWhile neoadjuvant chemoimmunotherapy (NACI) improves outcomes in resectable non-small cell lung cancer (NSCLC), a significant subset of patients exhibits innate resistance. Biomarkers predicting response are urgently needed.
Ru Xie, Ke Zhai, Jinming Yu, Miaoqing Zhao   +3 more
doaj   +2 more sources

A Nanobody-LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy. [PDF]

Adv Sci (Weinh)
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Qin S, Huang Z, Huang H, Zhang Y, Chen Y, He X, Niu Z, Xiang Z, Zou C, Song X.   +9 more
europepmc   +2 more sources

A lipid-based LMP2-mRNA vaccine to treat nasopharyngeal carcinoma

Nano Research, 2023
Nasopharyngeal carcinoma (NPC) is a serious and highly invasive epithelial malignancy that is closely associated with Epstein-Barr virus (EBV). Due to the lack of therapeutic vaccines for NPC, we selected EBV latent membrane protein 2 (LMP2) as a preferable targeting antigen to develop a lipid-based LMP2-mRNA (mLMP2) vaccine.
Xiangrong Song, Xing Duan, Mengran Guo   +2 more
exaly   +4 more sources

Epstein–Barr virus-specific T-cells in pediatric liver transplant recipients [PDF]

Scientific Reports
To determine Epstein–Barr virus (EBV)-specific T-cell responses after pediatric liver transplantation (LT), we monitored EBV viral load and IFNγ-producing specific T-cells reacting to BZLF1, EBNA1, and LMP2 antigens from peripheral immune cells before LT
Songpon Getsuwan, Nopporn Apiwattanakul, Chatmanee Lertudomphonwanit, Suradej Hongeng, Sophida Boonsathorn, Wiparat Manuyakorn, Pornthep Tanpowpong, Usanarat Anurathapan, Suporn Treepongkaruna   +8 more
doaj   +2 more sources

Molecular and Genetic Landscape of Intravenous Leiomyomatosis: A Narrative Review. [PDF]

Cancer Innov
Intravenous leiomyomatosis is a rare uterine benign tumor characterized by intravascular growth, quasi‑malignant behavior, and a high recurrence rate. This review summarizes its molecular and genetic research progress, compares it with similar tumors, discusses unsolved issues and prospects, contributing to its pathogenesis, diagnosis, and future ...
Li L, Zhou J, Kang J, Liu X, Chen R, Yuan M, Yu Z, Wang J.   +7 more
europepmc   +2 more sources

Genetic ablation of Lmp2 increases the susceptibility for impaired cardiac function

Frontiers in Molecular Biosciences
Proteasome degradation is an integral part of cellular growth and function. Proteasomal intervention may mitigate adverse myocardial remodeling, but is associated with the onset of heart failure. Previously, we have demonstrated that increasing abundance
Felix A. Trogisch, Felix A. Trogisch, Felix A. Trogisch, Franziska Koser, Synje Michel, David A. Liem, Bogdan I. Florea, Markus Hecker, Markus Hecker, Oliver Drews, Oliver Drews, Oliver Drews   +11 more
doaj   +3 more sources

Immunoproteasome Inhibition Modulates Microglial Polarization to Facilitate Anti-Inflammatory Responses and Hematoma Resolution After Intracerebral Hemorrhage [PDF]

Cells
Intracerebral hemorrhage induces severe secondary brain injury characterized by excessive neuroinflammation and inefficient hematoma clearance, processes largely governed by microglial polarization and phagocytic activity.
Wei-Fen Hu, Chien-Hui Lee, Hsin-Yi Huang, Cheng-Yoong Pang, Yi-Feng Wu, Tsung-Jen Lin, Peter Bor-Chian Lin, Sheng-Tzung Tsai, Chia-Ho Lin, Hock-Kean Liew   +9 more
doaj   +2 more sources

Neuroinflammation as a result of non-neurotropic herpesvirus infection. [PDF]

Immunol Cell Biol
Atypical memory B cells (ABCs) might stimulate autoreactive T cells to cause neuroinflammation and CNS myeloid cell activation during MS. Abstract The non‐neurotropic Epstein Barr virus (EBV) has been suggested to initiate the prodromal phase of multiple sclerosis (MS), often years before the first clinical symptoms. This review discusses mechanisms by
Münz C.
europepmc   +2 more sources

Molecular Mechanisms of Uterine Leiomyosarcomas: Involvement of Defect in LMP2 Expression [PDF]

Gene Regulation and Systems Biology, 2008
Patients with uterine leiomyosarcoma (LMS) typically present with vaginal bleeding, pain, and a pelvic mass. Typical presentations with hypercalcemia or eosinophilia have been reported. Radiographic evaluation with combined positron emission tomography/computed tomography may assist in the diagnosis and surveillance of women with uterine LMS.
Ikuo Konishi, Yuto Shimamura, Akiko Horiuchi   +2 more
exaly   +3 more sources