Results 1 to 10 of about 5,087 (193)

A potential diagnostic biomarker: Proteasome LMP2/b1i-differential expression in human uterus neoplasm

Nature Precedings, 2012
Uterine leiomyosarcoma (ULMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine ULMS
Takuma Hayashi, Akiko Horiuchi, Nobuo Yaegashi   +2 more
exaly   +2 more sources

Allelic variations in the TAP2 and LMP2 genes in Behçet's disease

Tissue Antigens, 1996
N Mizuki, T Naruse, S Kuwata
exaly   +3 more sources

Regulation of LMP2 and TAP1 Genes by IRF-1 Explains the Paucity of CD8+ T Cells in IRF-1−/− Mice

Immunity, 1996
The TAP1 and LMP2 genes are central for class I MHC function and share a common promoter. Here, we analyze the molecular mechanism of IFNγ up-regulation of TAP1 and LMP2.
Kenneth L Wright, Nathan J Felix, Luiz F L Reis   +2 more
exaly   +2 more sources

A bright approach to the immunoproteasome: Development of LMP2/β1i-specific imaging probes [PDF]

Bioorganic and Medicinal Chemistry, 2012
While the constitutive, 26S proteasome plays an important role in regulating many important cellular processes, a variant form known as the immunoproteasome is thought to primarily function in adaptive immune responses. However, recent studies indicate an association of immunoproteasomes with many physiological disorders such as cancer ...
Marie Wehenkel, Chang-Guo Zhan, Kyung Bo Kim   +2 more
exaly   +3 more sources

Polymorphism in the LMP2 and LMP7 genes and adult rheumatoid arthritis: no relationship with disease susceptibility or outcome

Tissue Antigens, 1995
Walter P Maksymowych, F Pazderka
exaly  

A Novel Diagnostic Marker: Proteasome LMP2/1i-Differential Expression in Human Uterus Mesenchymal Tumor

Cancer Research Journal, 2013
Takuma Hayashi, Akiko Horiuchi, Nobuo Yaegashi   +2 more
exaly  

Optimization of α-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 (β5i)/LMP2 (β1i) dual inhibitor

Bioorganic and Medicinal Chemistry
Yuuki Arai, Kei Sakata
exaly  

Genetic ablation of Lmp2 increases the susceptibility for impaired cardiac function [PDF]

Frontiers in Molecular Biosciences
Proteasome degradation is an integral part of cellular growth and function. Proteasomal intervention may mitigate adverse myocardial remodeling, but is associated with the onset of heart failure. Previously, we have demonstrated that increasing abundance
Felix A. Trogisch, Felix A. Trogisch, Felix A. Trogisch, Franziska Koser, Synje Michel, David A. Liem, Bogdan I. Florea, Markus Hecker, Markus Hecker, Oliver Drews, Oliver Drews, Oliver Drews   +11 more
doaj   +5 more sources

Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia [PDF]

Frontiers in Immunology, 2021
The immunoproteasome, a special isoform of the 20S proteasome, is expressed when the cells receive an inflammatory signal. Immunoproteasome inhibition proved efficacy in the treatment of autoimmune diseases.
Lu Liu, Miao Xu, Jun Peng
exaly   +5 more sources

LMP2 Inhibitors as a Potential Treatment for Alzheimer’s Disease

Journal of Medicinal Chemistry, 2020
The immunoproteasome (iP), an inducible proteasome variant harboring three immunosubunits, low molecular mass polypeptide-2 (LMP2), multicatalytic endopeptidase complex subunit-1, and low molecular mass polypeptide-7 (LMP7), is involved in multiple facets of inflammatory responses.
Deepak Bhattarai, Min Jae Lee, Ahruem Baek, In Jun Yeo, Zachary Miller, Yu Mi Baek, Sukyeong Lee, Dong-Eun Kim, Jin Tae Hong, Kyung Bo Kim   +9 more
core   +5 more sources