Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion [PDF]
Advanced ScienceAstrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined.
Yanguang Mao +7 more
doaj +3 more sources
Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia [PDF]
Frontiers in Immunology, 2021 The immunoproteasome, a special isoform of the 20S proteasome, is expressed when the cells receive an inflammatory signal. Immunoproteasome inhibition proved efficacy in the treatment of autoimmune diseases.
Ming Hou, Miao Xu
exaly +5 more sources
Immunoproteasome components LMP2, PSME1, and PSME2 as novel tissue biomarkers predicting response and survival in neoadjuvant chemoimmunotherapy for resectable NSCLC [PDF]
Frontiers in ImmunologyBackgroundWhile neoadjuvant chemoimmunotherapy (NACI) improves outcomes in resectable non-small cell lung cancer (NSCLC), a significant subset of patients exhibits innate resistance. Biomarkers predicting response are urgently needed.
Ru Xie +3 more
doaj +2 more sources
Epstein–Barr virus-specific T-cells in pediatric liver transplant recipients [PDF]
Scientific ReportsTo determine Epstein–Barr virus (EBV)-specific T-cell responses after pediatric liver transplantation (LT), we monitored EBV viral load and IFNγ-producing specific T-cells reacting to BZLF1, EBNA1, and LMP2 antigens from peripheral immune cells before LT
Songpon Getsuwan +8 more
doaj +2 more sources
Immunoproteasome Inhibition Modulates Microglial Polarization to Facilitate Anti-Inflammatory Responses and Hematoma Resolution After Intracerebral Hemorrhage [PDF]
CellsIntracerebral hemorrhage induces severe secondary brain injury characterized by excessive neuroinflammation and inefficient hematoma clearance, processes largely governed by microglial polarization and phagocytic activity.
Wei-Fen Hu +9 more
doaj +2 more sources
Immunoproteasome inhibition triggers protein stress and apoptosis in cells of B cell lineage without impairing vaccination-induced antibody responses [PDF]
Cell Death DiscoveryThe immunoproteasome (IP) is a specialized form of the 26S proteasome, in which the catalytic subunits β1c, β2c, and β5c of the standard proteasome are replaced by LMP2, MECL-1, and LMP7.
Dennis Mink +7 more
doaj +2 more sources
Targeting intracellular LMP2 with costimulatory signal–armed antibody-like TCR T cells [PDF]
JCI InsightExpanding the repertoire of CAR therapies to include intracellular antigens holds promise for treating a broad spectrum of malignancies. TCR-like T cells, capable of recognizing intracellular antigen–derived peptides in complex with HLA molecules (pHLA),
Jiali Cheng +18 more
doaj +2 more sources
BMC Cancer, 2023 Background The roles of low molecular mass polypeptide 2 (LMP2) and transporter-associated with antigen processing (TAP2) in tumorigenesis are controversial.
Zhengyan Cheng +4 more
doaj +1 more source
Genetic variability in LMP2 and LMP7 is associated with the risk of esophageal squamous cell carcinoma in the Kazakh population but is not associated with HPV infection. [PDF]
PLoS ONE, 2017 The Kazakh population in Xinjiang Province in northwestern China exhibits a high incidence of esophageal squamous cell carcinoma (ESCC). Although the etiology of esophageal carcinoma (EC) has not been elucidated, there are reports of the involvement of ...
Lan Yang +11 more
doaj +1 more source
Military Medical Research, 2021 Background Disruption of the blood–brain barrier (BBB) after a stroke can lead to brain injury and neurological impairment. Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2 (LMP2) in the ...
Xing-Yong Chen +6 more
doaj +1 more source