Results 11 to 20 of about 4,413 (167)
Association of an LMP2 Polymorphism with Acute Myeloid Leukemia and Multiple Myeloma
Asian Pacific Journal of Cancer Prevention, 2013 Hematological malignancies (HM) are a group of neoplasms derived from the cells of the bone marrow and lymphatic system. Genetic factors leading to susceptibility to HM have been investigated for years but little is known yet. Low molecular weight polypeptide (LMP) 2 and LMP7 genes are important subunits of the immunoproteasome and play significant ...
Nazli Bozman +2 more
exaly +5 more sources
A bright approach to the immunoproteasome: Development of LMP2/β1i-specific imaging probes [PDF]
Bioorganic and Medicinal Chemistry, 2012 While the constitutive, 26S proteasome plays an important role in regulating many important cellular processes, a variant form known as the immunoproteasome is thought to primarily function in adaptive immune responses. However, recent studies indicate an association of immunoproteasomes with many physiological disorders such as cancer ...
Chang-Guo Zhan, Marie Wehenkel
exaly +3 more sources
International Journal of Molecular Sciences, 2023 Cholesteatoma, accompanied by chronic inflammatory response, is characterized by invasive growth and osteolytic activity. As specific proteasome isoforms, the immunoproteasomes serve as an important modulator of inflammatory responses. The aim of the present study was to determine the biological activity of cholesteatoma through the analysis of the ...
Ewa Olszewska +2 more
exaly +3 more sources
Immunoproteasome inhibition triggers protein stress and apoptosis in cells of B cell lineage without impairing vaccination-induced antibody responses [PDF]
Cell Death DiscoveryThe immunoproteasome (IP) is a specialized form of the 26S proteasome, in which the catalytic subunits β1c, β2c, and β5c of the standard proteasome are replaced by LMP2, MECL-1, and LMP7.
Dennis Mink +7 more
doaj +2 more sources
The Proteasome Subunit LMP2/b1i In the Female Genital System [PDF]
Journal of Gynecology and Obstetrics, 2013 Protein degradation by the ubiquitin-proteasome system is central to cell homeostasis and survival. Defects in this process are associated with diseases such as cancer and neurodegenerative disorders. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
exaly +2 more sources
Targeting intracellular LMP2 with costimulatory signal–armed antibody-like TCR T cells [PDF]
JCI InsightExpanding the repertoire of CAR therapies to include intracellular antigens holds promise for treating a broad spectrum of malignancies. TCR-like T cells, capable of recognizing intracellular antigen–derived peptides in complex with HLA molecules (pHLA),
Jiali Cheng +18 more
doaj +2 more sources
BMC Cancer, 2023 Background The roles of low molecular mass polypeptide 2 (LMP2) and transporter-associated with antigen processing (TAP2) in tumorigenesis are controversial.
Zhengyan Cheng +4 more
doaj +1 more source
Genetic variability in LMP2 and LMP7 is associated with the risk of esophageal squamous cell carcinoma in the Kazakh population but is not associated with HPV infection. [PDF]
PLoS ONE, 2017 The Kazakh population in Xinjiang Province in northwestern China exhibits a high incidence of esophageal squamous cell carcinoma (ESCC). Although the etiology of esophageal carcinoma (EC) has not been elucidated, there are reports of the involvement of ...
Lan Yang +11 more
doaj +1 more source
LMP2 polymorphisms and spondyloarthropathies [PDF]
Annals of the Rheumatic Diseases, 1999 Dr Hohler and colleagues1 have examined LMP2 polymorphisms and extraspinal manifestations in spondyloarthropathies arriving at the conclusion that there is no independent association between LMP2 genotypes and the occurrence of uveitis in HLA-B27 positive subjects when stratified for HLA DR.
WALTER P MAKSYMOWYCH, T HÖHLER
openaire +1 more source
Military Medical Research, 2021 Background Disruption of the blood–brain barrier (BBB) after a stroke can lead to brain injury and neurological impairment. Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2 (LMP2) in the ...
Xing-Yong Chen +6 more
doaj +1 more source