Results 11 to 20 of about 4,438 (169)

Genetic ablation of Lmp2 increases the susceptibility for impaired cardiac function

Frontiers in Molecular Biosciences
Proteasome degradation is an integral part of cellular growth and function. Proteasomal intervention may mitigate adverse myocardial remodeling, but is associated with the onset of heart failure. Previously, we have demonstrated that increasing abundance
Felix A. Trogisch, Felix A. Trogisch, Felix A. Trogisch, Franziska Koser, Synje Michel, David A. Liem, Bogdan I. Florea, Markus Hecker, Markus Hecker, Oliver Drews, Oliver Drews, Oliver Drews   +11 more
doaj   +3 more sources

A Nanobody-LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy. [PDF]

Adv Sci (Weinh)
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Qin S, Huang Z, Huang H, Zhang Y, Chen Y, He X, Niu Z, Xiang Z, Zou C, Song X.   +9 more
europepmc   +2 more sources

Molecular and Genetic Landscape of Intravenous Leiomyomatosis: A Narrative Review. [PDF]

Cancer Innov
Intravenous leiomyomatosis is a rare uterine benign tumor characterized by intravascular growth, quasi‑malignant behavior, and a high recurrence rate. This review summarizes its molecular and genetic research progress, compares it with similar tumors, discusses unsolved issues and prospects, contributing to its pathogenesis, diagnosis, and future ...
Li L, Zhou J, Kang J, Liu X, Chen R, Yuan M, Yu Z, Wang J.   +7 more
europepmc   +2 more sources

LMP2 polymorphisms and spondyloarthropathies [PDF]

Annals of the Rheumatic Diseases, 1999
Dr Hohler and colleagues1 have examined LMP2 polymorphisms and extraspinal manifestations in spondyloarthropathies arriving at the conclusion that there is no independent association between LMP2 genotypes and the occurrence of uveitis in HLA-B27 positive subjects when stratified for HLA DR.
WALTER P MAKSYMOWYCH, T HÖHLER
openaire   +1 more source

LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions

Journal of Translational Medicine, 2023
Background Substantial evidence suggests that immunoproteasome is implicated in the various neurological diseases such as stroke, multiple sclerosis and neurodegenerative diseases.
Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang, Yinzhou Wang   +8 more
doaj   +1 more source

Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice. [PDF]

PLoS ONE, 2009
BACKGROUND:Oncocytes of the thyroid gland (Hürthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus.
Hiroaki J Kimura, Cindy Y Chen, Shey-Cherng Tzou, Roberto Rocchi, Melissa A Landek-Salgado, Koichi Suzuki, Miho Kimura, Noel R Rose, Patrizio Caturegli   +8 more
doaj   +1 more source

Neuroinflammation as a result of non-neurotropic herpesvirus infection. [PDF]

Immunol Cell Biol
Atypical memory B cells (ABCs) might stimulate autoreactive T cells to cause neuroinflammation and CNS myeloid cell activation during MS. Abstract The non‐neurotropic Epstein Barr virus (EBV) has been suggested to initiate the prodromal phase of multiple sclerosis (MS), often years before the first clinical symptoms. This review discusses mechanisms by
Münz C.
europepmc   +2 more sources

Association between plasma immunoproteasome and 90-day prognosis after first-ever ischemic stroke

Neural Regeneration Research, 2021
Many blood biomarkers are reportedly helpful for predicting post-stroke cognitive impairment (PSCI), but no biomarkers are widely used in clinical practice.
Xing-Yong Chen, Ming Fu, Shao-Fen Wan, Xu Zhang, Yin-Zhou Wang   +4 more
doaj   +1 more source

Constructing TC-1-GLUC-LMP2 Model Tumor Cells to Evaluate the Anti-Tumor Effects of LMP2-Related Vaccines [PDF]

Viruses, 2018
Epstein-Barr virus (EBV) is related to a variety of malignant tumors, and its encoded protein, latent membrane protein 2 (LMP2), is an effective target antigen that is widely used to construct vector vaccines. However, the model cells carrying LMP2 have still not been established to assess the oncolytic effect of LMP2-related vaccines at present.
Sun, Liying, Hao, Yanzhe, Wang, Zhan, Zeng, Yi   +3 more
openaire   +2 more sources

The impact of targeting repetitive BamHI-W sequences on the sensitivity and precision of EBV DNA quantification. [PDF]

PLoS ONE, 2017
Viral load monitoring and early Epstein-Barr virus (EBV) DNA detection are essential in routine laboratory testing, especially in preemptive management of Post-transplant Lymphoproliferative Disorder.
Armen Sanosyan, Alexis Fayd'herbe de Maudave, Karine Bollore, Valérie Zimmermann, Vincent Foulongne, Philippe Van de Perre, Edouard Tuaillon   +6 more
doaj   +1 more source