Results 41 to 50 of about 5,087 (193)

LMP2 and LMP7 gene polymorphism in Mexican populations: Mestizos and Amerindians [PDF]

Genes & Immunity, 2002
Low molecular weight polypeptide (LMP) genes are located within the major histocompatibility complex and have been associated with autoimmune diseases such as ankylosing spondylitis. In order to define the distribution of LMP genes in Mexican populations, the LMP2 and LMP7 polymorphism was analyzed in 312 Mexican individuals (95 Mexican Mestizos, 48 ...
G, Vargas-Alarcón, R, Gamboa, Y, Vergara, J M, Rodriguez-Zepeda, A, de la Peña, R, Izaguirre, J, Zuñiga, J A, Ruiz-Morales, J, Granados   +8 more
openaire   +2 more sources

No primary association between LMP2 polymorphisms and extraspinal manifestations in spondyloarthropathies [PDF]

Annals of the Rheumatic Diseases, 1997
To investigate the potential role of the HLA-linked LMP2 (low molecular weight protein) gene polymorphisms in conjunction with DR4 and DR7 on extraspinal disease manifestations in HLA-B27 positive patients with spondyloarthropathy.172 patients with spondyloarthropathy, 46 healthy, HLA-B27 positive blood donors, and 99 unrelated controls were typed for ...
T, Höhler, T, Schäper, P M, Schneider, F, Krummenauer, C, Rittner, K H, Meyer zum Büschenfelde, E, Märker-Hermann   +6 more
openaire   +2 more sources

Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy [PDF]

, 2011
Although the majority of smooth muscle neoplasms found in the uterus are benign, uterine leiomyosarcoma (LMS) is extremely malignant, with high rates of recurrence and metastasis.
Ryuichiro Nishimura, Nobuyoshi Hiraoka, Nobuo Yaegashi, Aburatani, Hiroyuki, Kenji Sano, Ichimura, Tomoyuki, Yoh-ichi Tagawa, Mari Kasai, Horiuchi, Akiko, Kanai, Yae, Yaegashi, Nobuo, Sano, Kenji, Nishimura, Ryuichiro, Sudo, Tamotsu, Kasai, Mari, Ishiko, Osamu, Shiozawa, Tanri, Hiraoka, Nobuyoshi, Tagawa, Yoh-ichi, Tanri Shiozawa, Yae Kanai, Osamu Ishiko, Hayashi, Takuma, Tamotsu Sudo, Ikuo Konishi, Akiko Horiuchi, Konishi, Ikuo, Takuma Hayashi, Tomoyuki Ichimura, Hiroyuki Aburatani   +29 more
core   +2 more sources

Reduced Expression of the Antigen Processing Machinery Components TAP2, LMP2, and LMP7 in Tonsillar and Base of Tongue Cancer and Implications for Clinical Outcome

Translational Oncology, 2015
OBJECTIVES: Patients with human papillomavirus (HPV)–positive tonsillar squamous cell carcinoma (TSCC) and base of tongue squamous cell carcinoma (BOTSCC) have a better clinical outcome than those with corresponding HPV-negative tumors.
Nikolaos Tertipis, Linnea Haeggblom, Nathalie Grün, Cecilia Nordfors, Anders Näsman, Tina Dalianis, Torbjörn Ramqvist   +6 more
doaj   +1 more source

'Off-the-shelf’ allogeneic antigen-specific adoptive T-cell therapy for the treatment of multiple EBV-associated malignancies

Journal for ImmunoTherapy of Cancer, 2021
Background Epstein-Barr virus (EBV), an oncogenic human gammaherpesvirus, is associated with a wide range of human malignancies of epithelial and B-cell origin.
Debottam Sinha, Sriganesh Srihari, Kirrliee Beckett, Laetitia Le Texier, Matthew Solomon, Archana Panikkar, George R Ambalathingal, Lea Lekieffre, Pauline Crooks, Sweera Rehan, Michelle A. Neller, Corey Smith, Rajiv Khanna   +12 more
doaj   +1 more source

Expression of HPV6b L1/EBV LMP2 multiepitope and immunogenicity in mice [PDF]

Acta Biochimica et Biophysica Sinica, 2010
Human papillomavirus (HPV) major capsid protein L1 is an important vehicle for the delivery of epitopes. To investigate the expression and immunogenicity of hybridized HPV6b L1 containing multiepitope of Epstein-Barr virus (EBV) latency membrane protein 2 (LMP2), a recombinant plasmid pcDNA3.1(+) containing mammalian codon-optimization HPV6b L1 gene ...
Shanli, Zhu, Xiangyang, Xue, Jianxiao, Liu, Lijun, Lu, Pengyun, Zhao, Jia, Wang, WenShu, Li, Lifang, Zhang   +7 more
openaire   +2 more sources

Application of Explicitly Localized Molecular Orbitals to Electronic Structure Calculations

CHIMIA, 2012
We have recently generalized the method for localizing orbitals on a set of predefined molecular fragments [Phys. Chem. Chem. Phys. 2012, 14, 546].
Piotr de Silva, Marcin Makowski, Jacek Korchowiec   +2 more
doaj   +1 more source

The β-carboline Harmine improves the therapeutic benefit of anti-PD1 in melanoma by increasing the MHC-I-dependent antigen presentation

Frontiers in Immunology, 2022
Harmine is a dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor that displays a number of biological and pharmacological properties. Also referred to as ACB1801 molecule, we have previously reported that harmine increases the presentation ...
Muhammad Zaeem Noman, Irene Adelaide Bocci, Manale Karam, Manale Karam, Kris Van Moer, Manon Bosseler, Akinchan Kumar, Guy Berchem, Guy Berchem, Christian Auclair, Christian Auclair, Bassam Janji   +11 more
doaj   +1 more source

Los genes TAP y EMP2 en el asma alérgica

Biomédica: revista del Instituto Nacional de Salud, 1997
Los pacientes con asma alérgica presentan una fuerte respuesta de IgE contra los alergenos de ácaros; por tanto, estudiar la inmunogenética de esta respuesta podría ayudar a entender la etiología de las enfermedades alérgicas.
Beatriz Martínez, Luis Caraballo
doaj   +1 more source

Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. [PDF]

PLoS ONE, 2016
The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome.
Haiming M Liu, Deborah A Ferrington, Cory W Baumann, LaDora V Thompson   +3 more
doaj   +1 more source