Results 41 to 50 of about 4,438 (169)
Angewandte Chemie International Edition, Volume 65, Issue 45, 2 November 2026.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +1 more source
The Epstein Barr virus circRNAome. [PDF]
PLoS Pathogens, 2018 Our appreciation for the extent of Epstein Barr virus (EBV) transcriptome complexity continues to grow through findings of EBV encoded microRNAs, new long non-coding RNAs as well as the more recent discovery of over a hundred new polyadenylated lytic ...
Nathan Ungerleider +14 more
doaj +1 more source
Pediatric Transplantation, Volume 30, Issue 10, October 2026.The T cell and Natural Killer cell immune responses in primary EBV infection in children or during progression to PTLD are not well characterized. By performing detailed prospective immunological phenotyping through the first year after 278 pediatric organ transplants, we will unearth pathways that may inform EBV oncogenesis progression.
Vikas R. Dharnidharka +22 more
wiley +1 more source
On the Role of the Immunoproteasome in Protein Homeostasis
Cells, 2021 Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
doaj +1 more source
Small, Volume 22, Issue 49, 1 September 2026.Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley +1 more source
LMP2-Specific Inhibitors: Chemical Genetic Tools for Proteasome Biology
Chemistry & Biology, 2007 The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. However, its other pathophysiological functions are still not very well understood.
Ho, Yik Khuan (Abby) +4 more
openaire +2 more sources
LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes [PDF]
Current Biology, 1995 Major histocompatibility complex (MHC) class I molecules present short peptides generated by intracellular protein degradation to cytotoxic T lymphocytes (CTL). The multisubunit, non-lysosomal proteinases known as proteasomes have been implicated in the generation of these peptides.
Sibille, Catherine +7 more
openaire +4 more sources
Scientific Reports, 2021 Epstein-Barr virus (EBV) has been recently found to generate novel circular RNAs (circRNAs) through backsplicing. However, comprehensive catalogs of EBV circRNAs in other cell lines and their functional characterization are still lacking.
Ke-En Tan +13 more
doaj +1 more source
The Proteasome Subunit LMP2/b1i In the Female Genital System [PDF]
Journal of Gynecology and Obstetrics, 2013 Protein degradation by the ubiquitin-proteasome system is central to cell homeostasis and survival. Defects in this process are associated with diseases such as cancer and neurodegenerative disorders. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
openaire +1 more source
Clinical‐Stage Nanatinostat Triggers Productive Epstein‐Barr Virus Lytic Replication
Journal of Medical Virology, Volume 98, Issue 8, August 2026.ABSTRACT A phase 1b/2 study of the all‐oral “kick‐and‐kill” combo nanatinostat + valganciclovir (nana‐val) showed a ~40% overall response rate in patients with relapsed/refractory Epstein‐Barr virus (EBV)‐associated lymphomas. Despite the promising results in these difficult‐to‐treat cancers, there is little known about the effects of nanatinostat on ...
Ibukun A. Akinyemi +6 more
wiley +1 more source