Results 61 to 70 of about 4,438 (169)

Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity [PDF]

The EMBO Reports, 2018
Cells of hematopoietic origin express high levels of the immunoproteasome, a cytokine-inducible proteasome variant comprising the proteolytic subunits LMP2 (β1i), MECL-1 (β2i), and LMP7 (β5i). Targeting the immunoproteasome in pre-clinical models of autoimmune diseases with the epoxyketone inhibitor ONX 0914 has proven to be effective.
Michael Basler, Michelle M Lindstrom, Jacob J LaStant, J Michael Bradshaw, Timothy D Owens, Christian Schmidt, Elmer Maurits, Christopher Tsu, Herman S Overkleeft, Christopher J Kirk, Claire L Langrish, Marcus Groettrup   +11 more
openaire   +5 more sources

Distinct Proteasome Subpopulations in the Alveolar Space of Patients with the Acute Respiratory Distress Syndrome

Mediators of Inflammation, 2012
There is increasing evidence that proteasomes have a biological role in the extracellular alveolar space, but inflammation could change their composition.
S. U. Sixt, R. Alami, J. Hakenbeck, M. Adamzik, A. Kloß, U. Costabel, P. R. Jungblut, B. Dahlmann, J. Peters   +8 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma [PDF]

Journal of Virology, 1992
Two species of the Epstein-Barr virus-encoded latent membrane protein 2, LMP2A and LMP2B, are generated by alternative splicing, each species having a distinct first exon. LMP2 transcription in undifferentiated nasopharyngeal carcinoma (NPC), which is consistently associated with the Epstein-Barr virus, was investigated.
P, Busson, R, McCoy, R, Sadler, K, Gilligan, T, Tursz, N, Raab-Traub   +5 more
openaire   +2 more sources

Novel Synthetic DNA Immunogens Targeting Latent Expressed Antigens of Epstein–Barr Virus Elicit Potent Cellular Responses and Inhibit Tumor Growth

Vaccines, 2019
Infectious diseases are linked to 15%−20% of cancers worldwide. Among them, Epstein−Barr virus (EBV) is an oncogenic herpesvirus that chronically infects over 90% of the adult population, with over 200,000 cases of cancer and 150,000 cancer ...
Krzysztof Wojtak, Alfredo Perales-Puchalt, David B. Weiner   +2 more
doaj   +1 more source

Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. [PDF]

PLoS ONE, 2016
Immunoproteasomes, harboring the active site subunits β5i/LMP7, β1i/LMP2, and β2i/MECL1 exert protective, regulatory or modulating functions during infection-induced immune responses.
Felicia Kirschner, Katrin Reppe, Nadine Andresen, Martin Witzenrath, Frédéric Ebstein, Peter-Michael Kloetzel   +5 more
doaj   +1 more source

Involvement of proteasome β1i subunit, LMP2, on development of uterin leiomyosarcma

North American Journal of Medical Sciences, 2011
Although the majority of smooth muscle neoplasms found in the uterus are benign, uterine leiomyosarcoma is extremely malignant, with high rates of recurrence and metastasis. The development of gynecologic tumors is often correlated with secretion of female hormone; however, the development of human uterine leiomyosarcoma is not substantially correlated
Hayashi, Takuma, Horiuchi, Akiko, Sano, Kenji, Hiraoka, Nobuyoshi, Kasai, Mari, Ichimura, Tomoyuki, Nagase, Satoru, Ishiko, Osamu, Shiozawa, Tanri, Kanai, Yae, Yaegashi, Nobuo, Aburatani, Hiroyuki, Tonegawa, Susumu, Konishi, Ikuo   +13 more
openaire   +2 more sources

Sinomenine Regulates PSMB9 to Mediate Therapeutic Effects in Rheumatoid Arthritis

Cells
Rheumatoid arthritis (RA) is a systemic immune-related disease characterized by chronic synovial inflammation and progressive joint destruction. However, the molecular mechanisms and diagnostic biomarkers underlying RA remain unclear.
Cui Zhang, Chonkit Lio, Nana Li, Yang Yu, Jinfang Luo   +4 more
doaj   +1 more source

Manufacturing and clinical applications of non‐CAR‐T immune effector cells

Transfusion, Volume 66, Issue S2, Page S29-S44, September 2026.
Thane Kubik, Theodros Mamo, David H. McKenna   +2 more
wiley   +1 more source

Molecular Mimicry Between Epstein‐Barr Virus and Human Herpesvirus‐6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background The Epstein‐Barr virus (EBV) and human herpesvirus 6 (HHV‐6) are frequently linked to neuropsychiatric illnesses such as multiple sclerosis, depression, and chronic fatigue syndrome/myalgic encephalomyelitis. These viruses may induce autoimmune reactions by molecular mimicry, leading to damage to self‐epitopes in the central nervous
Abbas F. Almulla, Muslimbek G. Normatov, Thitiporn Supasitthumrong, Michael Maes   +3 more
wiley   +1 more source