Results 81 to 90 of about 5,087 (193)

Subversion of immunoproteasome subunit expression in dengue virus serotype 2-infected HepG2 cells

Revista da Sociedade Brasileira de Medicina Tropical
: INTRODUCTION: Infection with all serotypes of dengue virus (DV) results in augmented antigen presentation by MHC class I molecules. However, the upregulation of immunoproteasome subunits only results from infection with two serotypes. This study aims
Chye Sheng Gan, Pei Jean Lim, Muhammad Fazril Mohamad Razif, Rohana Yusof, Shatrah Othman   +4 more
doaj   +1 more source

Beyond PD‐1: Mechanisms of Resistance to Checkpoint Blockade in Classical Hodgkin Lymphoma and Next‐Generation Immune Strategies

European Journal of Haematology, Volume 116, Issue 4, Page 357-367, April 2026.
ABSTRACT PD‐1 inhibitors have reshaped the treatment landscape of classical Hodgkin lymphoma, yet a substantial proportion of patients exhibit primary or acquired resistance driven by tumor‐intrinsic alterations, immunosuppressive microenvironmental signals, metabolic constraints, and EBV‐mediated modulation.
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma [PDF]

, 2010
Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS ...
Tonegawa, Susumu, Nobuyoshi Hiraoka, Tanri Shiozawa, Yae Kanai, Hiraoka, Nobuyoshi, Konishi, Ikuo, Kenji Sano, Hayashi, Takuma, Ikuo Konishi, Sano, Kenji, Kanai, Yae, Akiko Horiuchi, Shiozawa, Tanri, Takuma Hayashi, Horiuchi, Akiko, Susumu Tonegawa   +15 more
core   +1 more source

Novel Synthetic DNA Immunogens Targeting Latent Expressed Antigens of Epstein–Barr Virus Elicit Potent Cellular Responses and Inhibit Tumor Growth

Vaccines, 2019
Infectious diseases are linked to 15%−20% of cancers worldwide. Among them, Epstein−Barr virus (EBV) is an oncogenic herpesvirus that chronically infects over 90% of the adult population, with over 200,000 cases of cancer and 150,000 cancer ...
Krzysztof Wojtak, Alfredo Perales-Puchalt, David B. Weiner   +2 more
doaj   +1 more source

Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. [PDF]

PLoS ONE, 2016
Immunoproteasomes, harboring the active site subunits β5i/LMP7, β1i/LMP2, and β2i/MECL1 exert protective, regulatory or modulating functions during infection-induced immune responses.
Felicia Kirschner, Katrin Reppe, Nadine Andresen, Martin Witzenrath, Frédéric Ebstein, Peter-Michael Kloetzel   +5 more
doaj   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

The Proteasome Subunit LMP2/b1i In the Female Genital System [PDF]

Journal of Gynecology and Obstetrics, 2013
Protein degradation by the ubiquitin-proteasome system is central to cell homeostasis and survival. Defects in this process are associated with diseases such as cancer and neurodegenerative disorders. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.
openaire   +1 more source

Immunoproteasome deficiency modifies the alternative pathway of NFκB signaling. [PDF]

PLoS ONE, 2013
Immunoproteasome is a protease abundant in immune cells and also present, albeit at lower concentrations, in cells outside the immune system. Recent evidence supports a novel role for the immunoproteasome in the cellular stress response potentially ...
Marcela Maldonado, Rebecca J Kapphahn, Marcia R Terluk, Neal D Heuss, Ching Yuan, Dale S Gregerson, Deborah A Ferrington   +6 more
doaj   +1 more source

Abstract 2631: Target validation of the LMP2 inhibitor, UK-101

, 2010
Introduction: The purpose of this study is to determine the mechanism(s) of action of the novel LMP2 inhibitor, UK-101. LMP2 is a major catalytic subunit of the immunoproteasome, an alternative form of the constitutive proteasome, and its upregulation ...
Kyung Bo Kim, Marie Wehenkel
core   +1 more source

ACTIVATION MECHANISMS OF GUT-ASSOCIATED LYMPHOID TISSUE UNDER CHRONIC SOCIAL STRESS CONDITIONS

Медицинская иммунология, 2015
Stress-induced immune disregulation is a risk factor of autoimmune and inflammatory diseases, but, so far, the mechanisms for this effect are not fully known. Expression levels of specific mRNAs were assessed in gut-associated lymphoid tissue (GALT) from
A. M. Kamyshnyi, I. A. Topol
doaj   +1 more source