Results 81 to 90 of about 4,413 (167)
Novel Immunotherapy Options for Extranodal NK/T-Cell Lymphoma
Frontiers in Oncology, 2018 Extranodal NK/T-cell lymphoma (ENKTCL) is a highly aggressive mature NK/T-cell neoplasm marked by NK-cell phenotypic expression of CD3ε and CD56. While the disease is reported worldwide, there is a significant geographic variation with its highest ...
Boyu Hu, Yasuhiro Oki
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The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome
Proceedings of the National Academy of Sciences, 1997 Processing of antigens for presentation by major histocompatibility complex (MHC) class I molecules requires the activity of the proteasome. The 20S proteasome complex is composed of 14 different subunits, 2 of which can be substituted by the interferon γ (IFN-γ)-inducible and MHC-encoded subunits LMP2 and LMP7 (low molecular mass poylpeptides 2 and 7).
M, Groettrup +3 more
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EJC Supplements, 2015 The tumor microenvironment plays an important role in the progression of cancer and may be regulated by proteolysis, including the proteasomes. The proteasomes modify the biologically important molecules involved in the pathogenesis and progression of a ...
E. Shashova +5 more
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Scientific Reports, 2017 Merkel cell carcinoma (MCC) is a rare and aggressive, yet highly immunogenic skin cancer. The latter is due to its viral or UV-associated carcinogenesis. For tumor progression MCC has to escape the host’s immuno-surveillance, e.g.
Cathrin Ritter +8 more
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PharmaceuticsBackground: The Epstein-Barr virus (EBV) is intricately linked to a range of human malignancies, with EBV latent membrane protein 2A (LMP2A) emerging as a potential target antigen for immunotherapeutic strategies in the treatment of nasopharyngeal ...
Liying Sun, Chao Liu, Junping Peng
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Characterization of the immunproteasome subunits LMP2 and LMP7 in the mouse brain
, 2018 Die hier verfasste Dissertation beinhaltet eine Lokalisationsstudie sowie eine funktionelle Charakterisierung der katalytischen Untereinheiten LMP2 und LMP7 des Immunoproteasomes (IPs) im Gehirn der Maus. Das IP ist eine spezifische Form des Proteasoms, welches konstitutiv in Zellen des Immunsystems exprimiert wird und auf Grund seiner speziellen ...
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Major Histocompatibility-encoded Human Proteasome LMP2 [PDF]
Journal of Biological Chemistry, 1995 Dharam P. Singal +2 more
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Astrocytic LMP2 Coordinates NF-κB and TGF-β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion. [PDF]
Adv Sci (Weinh)Mao Y +7 more
europepmc +1 more source