Results 101 to 110 of about 5,087 (193)

The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome

Proceedings of the National Academy of Sciences, 1997
Processing of antigens for presentation by major histocompatibility complex (MHC) class I molecules requires the activity of the proteasome. The 20S proteasome complex is composed of 14 different subunits, 2 of which can be substituted by the interferon γ (IFN-γ)-inducible and MHC-encoded subunits LMP2 and LMP7 (low molecular mass poylpeptides 2 and 7).
M, Groettrup, S, Standera, R, Stohwasser, P M, Kloetzel   +3 more
openaire   +3 more sources

In vitro anti-tumor immune response induced by dendritic cells transfected with EBV-LMP2 recombinant adenovirus

, 2006
Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is a high-incidence tumor in southern China. Latent membrane proteins 2 (LMP2) is a subdominant antigen of EBV.
Zhang, Jinkun, Zuo, Jianmin; id_orcid, Zhou, Ling, Zeng, Yi, Pan, Ying   +4 more
core   +1 more source

P13

EJC Supplements, 2015
The tumor microenvironment plays an important role in the progression of cancer and may be regulated by proteolysis, including the proteasomes. The proteasomes modify the biologically important molecules involved in the pathogenesis and progression of a ...
E. Shashova, E. Kolegova, Yu. Lyupina, E. Slonimskaya, I. Kondakova, N. Sharova   +5 more
doaj   +1 more source

DataSheet1_Genetic ablation of Lmp2 increases the susceptibility for impaired cardiac function.pdf

Proteasome degradation is an integral part of cellular growth and function. Proteasomal intervention may mitigate adverse myocardial remodeling, but is associated with the onset of heart failure. Previously, we have demonstrated that increasing abundance
David A. Liem (1849339), Oliver Drews (57590), Franziska Koser (18118582), Markus Hecker (63819), Felix A. Trogisch (11498311), Synje Michel (18118585), Bogdan I. Florea (1330800)   +6 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Immunoproteasome subunit LMP2 expression is deregulated in Sjögren's syndrome but not in other autoimmune disorders [PDF]

, 2006
Background: The proteasome system has a pivotal role in the control of the immune response, which suggests that it might be involved in the pathogenesis of autoimmune disorders.Objective: To investigate the expression profile of selected proteasomal ...
Krause, S., Dörner, T., Burmester, G-R, Feist, E., Kuckelkorn, U., Kloetzel, P-M   +5 more
core   +1 more source

Proteasome LMP2/β1i subunit as biomarker for human uterine leiomyosarcoma

, 2014
Uterine leiomyosarcoma (Ut-LMS) develops more frequently in the myometrium of the uterine body than in the uterine cervix. Although the development of gynecological tumors is often correlated with the secretion of female hormones that of Ut-LMS does not,
Horiuchi, Akiko; Horiuchi Ladies Clinic, Matsumoto, Nagano, Japan, Konishi, Ikuo; Department of Obstetrics and Gynecology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kanai, Yae; Pathology Division, National Cancer Center Research Institute, Chuoku, Tokyo, Japan., Yaegashi, Nobuo; Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan., Tonegawa, Susumu; Picower Institution and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Zharhary, Dorit; Sigma-Aldrich Israel Ltd., Rehovot 76100, Israel., Hayashi, Takuma; Department of Immunology and Infectious Disease, Shinshu University School of Medicine, Matsumoto, Nagano, Japan., Aburatani, Hiroyuki; The Cancer System Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Ishiko, Osamu; Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Japan.   +8 more
core   +1 more source

Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma

Scientific Reports, 2017
Merkel cell carcinoma (MCC) is a rare and aggressive, yet highly immunogenic skin cancer. The latter is due to its viral or UV-associated carcinogenesis. For tumor progression MCC has to escape the host’s immuno-surveillance, e.g.
Cathrin Ritter, Kaiji Fan, Annette Paschen, Sine Reker Hardrup, Soldano Ferrone, Paul Nghiem, Selma Ugurel, David Schrama, Jürgen C. Becker   +8 more
doaj   +1 more source

Characterization of the immunproteasome subunits LMP2 and LMP7 in the mouse brain

, 2018
Die hier verfasste Dissertation beinhaltet eine Lokalisationsstudie sowie eine funktionelle Charakterisierung der katalytischen Untereinheiten LMP2 und LMP7 des Immunoproteasomes (IPs) im Gehirn der Maus. Das IP ist eine spezifische Form des Proteasoms, welches konstitutiv in Zellen des Immunsystems exprimiert wird und auf Grund seiner speziellen ...
openaire   +2 more sources

The E.coli Heat Labile Enterotoxin B-Subunit Enhances CD8+ T-Cell Killing of Epithelial Tumour Cells Expressing EBV LMP2

, 2006
Background: EBV LMP2 is a potential tumour immunotherapeutic target but EBV lymphoblastoid cell lines (LCL) are not normally susceptible to killing by uncloned LMP2-specfic CD8+ cytotoxic T-cells (CTL) in vitro unless pulsed with epitope peptide or if ...
Wilson, AD, Morgan, AJ, Salim, O
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