Results 111 to 120 of about 5,087 (193)

Characterization of the Interaction between the Matrix Protein of Vesicular Stomatitis Virus and the Immunoproteasome Subunit LMP2

, 2015
International audienceThe matrix protein (M) of vesicular stomatitis virus (VSV) is involved in virus assembly, budding, gene regulation, and cellular pathogenesis. Using a yeast two-hybrid system, the M globular domain was shown to interact with LMP2, a
Beilstein, Frauke, Obiang, Linda, Raux, Hélène, Gaudin, Yves   +3 more
core   +1 more source

A NOVEL CLASS OF IMMUNOPROTEASOME CATALYTIC SUBUNIT LMP2 INHIBITOR AND ITS THERAPEUTIC POTENTIALS IN CANCER

, 2008
The immunoproteasome, known to play an important role in MHC class I antigen processing and presentation, have been linked to neurodegenerative diseases and hematological cancers. However, the pathophysiological functions of the immunoproteasome in these
Ho, Yik Khuan (Abby)
core  

Schematic representation of role for LMP2 in early EBV infection leading to B cell proliferation.

, 2013
Schematic representation of role for LMP2 in early EBV infection leading to B cell proliferation.
David T. Rowe (290381), Laura R. Wasil (290376), Aki Hoji (290379), Monica J. Tomaszewski (290378)   +3 more
core   +1 more source

EBV Gene Expression in early EBV infection with LMP2 KO viruses.

, 2013
1×106 purified B cells were infected with recombinant wt and LMP2 KO EBV at MOI 1. (A) RNA was harvested for analysis at 12, 24, 48, 72, 96, 120 and 168 hours post-infection and analyzed by Real Time PCR to determine the effect of LMP2 on latent gene ...
David T. Rowe (290381), Laura R. Wasil (290376), Aki Hoji (290379), Monica J. Tomaszewski (290378)   +3 more
core   +1 more source

Abstract 2624: Targeted inhibition of the immunoproteasome subunit LMP2 using UK-101 induces apoptotic cell death in colorectal cancer

, 2010
Background: The immunoproteasome is an alternative form of the constitutive proteasome and it has been increasingly shown to play an important role in a number of diseases including cancer and inflammatory diseases. We have previously developed ‘UK-101’,
Kyung-Bo Kim, Eun Y. Lee, Kyunghwa Kim, Marie Wehenkel, Wooin Lee, Eun Ryoung Jang   +5 more
core   +1 more source

Major Histocompatibility-encoded Human Proteasome LMP2 [PDF]

Journal of Biological Chemistry, 1995
Dharam P. Singal, Ming Ye, Shafat A. Quadri   +2 more
openaire   +1 more source

The MHC-encoded TAP1/LMP2 bidirectional promoter is down-regulated in highly oncogenic adenovirus type 12 transformed cells

, 1997
Cells transformed by human adenovirus 12 (Ad12) exhibit extremely low surface levels of MHC class I molecules and contain reduced levels of class I heavy chain mRNAs.
Blair, G.Eric, Proffitt, James A
core   +1 more source

A role for SHP-1 and Vav in the abrogation of B cell receptor signal transduction by latent membrane protein 2 (LMP2)

, 1997
grantor: University of TorontoLatent membrane protein 2 (LMP2) has been reported to block signal transduction through the B cell receptor (BCR) in Epstein-Barr virus-transformed lymphoblastoid cell lines (LCLs) through recruitment of Syk and ...
Glasier, Mary-Ann M.
core   +1 more source

The E.Coli Heat Labile Enterotoxin B-Subunit Enhances CD8+ T-Cell Killing Of An Epithelial Tumour Cell Line Expressing EBV LMP2

, 2007
EBV LMP2 is a potential tumour immunotherapeutic target but EBV lymphoblastoid cell lines (LCL) are not normally susceptible to killing by uncloned LMP2-specfic CD8+ cytotoxic T-cells (CTL) in vitro unless pulsed with epitope peptide or if LMP2 is ...
Wilson, AD, Morgan, AJ, Salim, O
core  

MVA-EBNA1/LMP2 Vaccine [PDF]

, 2020
openaire   +1 more source