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A Lipid-Based LMP2-mRNA Vaccine to Treat Nasopharyngeal Carcinoma

Nano Research, 2023
Nasopharyngeal carcinoma (NPC) is a serious and highly invasive epithelial malignancy that is closely associated with Epstein-Barr virus (EBV). Due to the lack of therapeutic vaccines for NPC, we selected EBV latent membrane protein 2 (LMP2) as a preferable targeting antigen to develop a lipid-based LMP2-mRNA (mLMP2) vaccine.
Guo Mengran, Xing Duan
exaly   +4 more sources

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Immunoproteasome and LMP2 Polymorphism in Aged and Alzheimer's Disease Brains

Neurobiology of Aging, 2006
In this study, we investigated the presence and role of immunoproteasome and its LMP2 subunit polymorphism at codon 60 in Alzheimer's disease (AD). Immunoproteasome was present in brain areas such as hippocampus and cerebellum and localized in neurons, astrocytes and endothelial cells.
Annalisa Pession, Benedetta Nacmias, Claudio Franceschi   +2 more
exaly   +4 more sources

LMP2 Inhibitors as a Potential Treatment for Alzheimer’s Disease

Journal of Medicinal Chemistry, 2020
The immunoproteasome (iP), an inducible proteasome variant harboring three immunosubunits, low molecular mass polypeptide-2 (LMP2), multicatalytic endopeptidase complex subunit-1, and low molecular mass polypeptide-7 (LMP7), is involved in multiple facets of inflammatory responses.
Deepak Bhattarai, Min Jae Lee, Ahruem Baek, In Jun Yeo, Zachary Miller, Yu Mi Baek, Sukyeong Lee, Dong-Eun Kim, Jin Tae Hong, Kyung Bo Kim   +9 more
openaire   +2 more sources

Association of an LMP2 Polymorphism With Acute Myeloid Leukemia and Multiple Myeloma

Asian Pacific Journal of Cancer Prevention, 2013
Hematological malignancies (HM) are a group of neoplasms derived from the cells of the bone marrow and lymphatic system. Genetic factors leading to susceptibility to HM have been investigated for years but little is known yet. Low molecular weight polypeptide (LMP) 2 and LMP7 genes are important subunits of the immunoproteasome and play significant ...
Nazli Bozman, Mustafa Pehlivan, Filiz Özbaş Gerçeker   +2 more
exaly   +5 more sources

Allelic Variations in the TAP2 and LMP2 Genes in Behçet's Disease

Tissue Antigens, 1996
S Kuwata, N Mizuki, H Kawata
exaly   +3 more sources

[Expression and purification of EBV-LMP2 protein].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2011
To obtain a second Epstein-Barr virus membrane protein (LMP2) in insect cells.The full length EBV-LMP2 gene was inserted into baculovirus expression transfer vector pFastBac HT B to obtain the recombinant baculoviruses Bac-LMP2. And generation of recombinant baculoviruses was followed by transfection of the recombinant Bac-LMP2 into insect cells, then ...
Zhan, Wang, Jing, Ma, Ling, Zhou, Xiao-Guang, Zhang, Hai-Jun, Du, Song-Mei, Yang, Yi, Zeng   +6 more
openaire   +2 more sources

Latent Membrane Protein 2 (LMP2)

2015
LMP2A is an EBV-encoded protein with three domains: (a) an N-terminal cytoplasmic domain, which has PY motifs that bind to WW domain-containing E3 ubiquitin ligases and an ITAM that binds to SH2 domain-containing proteins, (b) a transmembrane domain with 12 transmembrane segments that localizes LMP2A in cellular membranes, and (c) a 27-amino acid C ...
Osman, Cen, Richard, Longnecker
openaire   +2 more sources

No independent associations of LMP2 and LMP7 polymorphisms with susceptibility to develop IDDM

Diabetes, 1997
Results from a recent study suggested that polymorphisms within the HLA class II genes LMP2 and LMP7 were associated with the susceptibility for developing IDDM, and that this association could not be explained by linkage disequilibrium to HLA-DR or -DQ genes.
D E, Undlien, H E, Akselsen, G, Joner, K, Dahl-Jørgensen, O, Søvik, K S, Rønningen, E, Thorsby   +6 more
openaire   +2 more sources

LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer.

Biomedical and environmental sciences : BES, 2021
To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2 (LMP2) modified dendritic cells (DCs) that boosts specific responses of cytotoxic T lymphocytes (CTLs) to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma (NPC).DCs were derived from peripheral blood monocytes of patients with ...
Yi, Zeng, Yong Feng, Si, Gui Ping, Lan, Zhan, Wang, Ling, Zhou, Min Zhong, Tang, O Brien, Sj, Jiao, Lan, Xiang Yang, Zhou, Yong Li, Wang, Juan, Tang, Zhi Xiang, Zhou, Hai Jun, Du, Hui, Lin   +13 more
openaire   +1 more source