Results 141 to 150 of about 4,413 (167)

No independent associations of LMP2 and LMP7 polymorphisms with susceptibility to develop IDDM

Diabetes, 1997
Results from a recent study suggested that polymorphisms within the HLA class II genes LMP2 and LMP7 were associated with the susceptibility for developing IDDM, and that this association could not be explained by linkage disequilibrium to HLA-DR or -DQ genes.
D E, Undlien, H E, Akselsen, G, Joner, K, Dahl-Jørgensen, O, Søvik, K S, Rønningen, E, Thorsby   +6 more
openaire   +2 more sources

LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer.

Biomedical and environmental sciences : BES, 2021
To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2 (LMP2) modified dendritic cells (DCs) that boosts specific responses of cytotoxic T lymphocytes (CTLs) to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma (NPC).DCs were derived from peripheral blood monocytes of patients with ...
Yi, Zeng, Yong Feng, Si, Gui Ping, Lan, Zhan, Wang, Ling, Zhou, Min Zhong, Tang, O Brien, Sj, Jiao, Lan, Xiang Yang, Zhou, Yong Li, Wang, Juan, Tang, Zhi Xiang, Zhou, Hai Jun, Du, Hui, Lin   +13 more
openaire   +1 more source

Dextran Sulfate Sodium-Induced Colitis Is Associated with Enhanced Low Molecular Mass Polypeptide 2 (LMP2) Expression and Is Attenuated in LMP2 Knockout Mice

Digestive Diseases and Sciences, 2006
Low molecular mass polypeptide 2 (LMP2) is an inducible proteasome subunit. Our goals were to examine LMP2 expression in mice with dextran sulfate sodium (DSS)-induced colitis and to evaluate colitis in LMP2 knockout (LMP2-/-) mice. Mice were given 2.5% DSS in the drinking water.
Leo R, Fitzpatrick, Vineeta, Khare, Jeffrey S, Small, Walter A, Koltun   +3 more
openaire   +2 more sources

Reply to 'LMP2 expression and proteasome activity in NOD mice'

Nature Medicine, 2000
In our paper, we described developmentally expressed defects in splenocytes and macrophages in NF-B activation and LMP2 expression in the NOD mouse4. These defects parallel disease expression, which occurs in 30% of males and 70% of females by 30 weeks of age13, and we emphasized that such abnormalities are never seen early in life. In contrast, we and
, Hayashi, , Kodama, , Faustman
openaire   +2 more sources

Association analysis of polymorphisms of porcine LMP2 and LMP7 genes with haematological traits

Molecular Biology Reports, 2010
Low molecular weight polypeptides 2 (LMP2) and low molecular weight polypeptides 7 (LMP7) are located within the major histocompatibility complex and have been associated with autoimmune disease. In this study, polymorphisms of porcine LMP2 and LMP7 genes were analyzed by PCR-SSCP and DNA sequencing methods.
Y, Liu, Y R, Luo, X, Lu, X T, Qiu, J P, Zhou, Y F, Gong, X D, Ding, Q, Zhang   +7 more
openaire   +2 more sources

Selected Contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis

Journal of Applied Physiology, 2001
Recent results in an animal model of autoimmune diabetes, the nonobese diabetic (NOD) mouse, suggest a hypothesis to explain the role of major histocompatibility complex (MHC) in autoimmunity. The genome MHC region contains immune response genes that are important for T cell education and antigen presentation by MHC molecules.
T, Hayashi, D L, Faustman
openaire   +2 more sources

[Dendritic cells transfected with recombinant adenovirus Ad5F35-LMP2 induces LMP2 specific immunity mediated by cytotoxic T lymphocytes in vitro].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2009
To observe whether dendritic cells (DCs) transfected with recombinant adenovirus Ad5F35-LMP2 induces LMP2 specific immunity mediated by cytotoxic T lymphocytes in vitro.Dendritic cells have been generated in vitro, and cocultured with autologous T cell after the DCs were infected with Ad5F35-LMP2, then the proliferation of the induced T cells and their
Wu-Ning, Mo, Ling, Zhou, Zhan, Wang, An-Zhou, Tang, Guang-Wu, Huang, Yi, Zeng   +5 more
openaire   +1 more source

[Expression and significance of LMP2 and PPM1A in gestational trophoblastic disease].

Zhonghua fu chan ke za zhi, 2012
To investigate the expression of low molecular mass polypeptide-2 (LMP2) and protein phosphatase 1A (PPM1A) in gestational trophoblastic disease and elucidate their predictive value in malignant transformation of hydatidiform mole.The expressions of LMP2 and PPM1A protein in 196 complete hydatidiform moles (in which 28 cases with malignant ...
Sha-sha, Zhang, Xiao-yun, Wan, Cai-yun, Zhou, Wei-guo, Lü, Xing, Xie   +4 more
openaire   +1 more source

MHC encoded LMP2 and LMP7 subunits of the Proteasome: study of a lymphoblastoid cell line lacking LMP2 subunit

Human Immunology, 1996
H. Teisserenc, M. Belich, C. Lafaurie, P. Loiseau, J. Trowsdale, D. Charron   +5 more
openaire   +1 more source

Immunoproteasome Subunit Low Molecular Mass Peptide 2 (LMP2) Deficiency Ameliorates LPS/Aβ1-42-Induced Neuroinflammation

Molecular Neurobiology, 2023
Yingchun Liu
exaly