Results 71 to 80 of about 4,413 (167)
Sinomenine Regulates PSMB9 to Mediate Therapeutic Effects in Rheumatoid Arthritis
CellsRheumatoid arthritis (RA) is a systemic immune-related disease characterized by chronic synovial inflammation and progressive joint destruction. However, the molecular mechanisms and diagnostic biomarkers underlying RA remain unclear.
Cui Zhang +4 more
doaj +1 more source
Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
Reviews in Medical Virology, Volume 36, Issue 3, May 2026.ABSTRACT Epstein‐Barr virus (EBV) is a ubiquitous herpesvirus and a causal factor for Burkitt Lymphoma (BL), Hodgkin Lymphoma (HL), gastric carcinoma (GC) and nasopharyngeal carcinoma (NPC). Whether EBV contributes to a wider spectrum of cancers remains uncertain.
Marisa D. Muckian +4 more
wiley +1 more source
ACTIVATION MECHANISMS OF GUT-ASSOCIATED LYMPHOID TISSUE UNDER CHRONIC SOCIAL STRESS CONDITIONS
Медицинская иммунология, 2015 Stress-induced immune disregulation is a risk factor of autoimmune and inflammatory diseases, but, so far, the mechanisms for this effect are not fully known. Expression levels of specific mRNAs were assessed in gut-associated lymphoid tissue (GALT) from
A. M. Kamyshnyi, I. A. Topol
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LMP2 expression and proteasome activity in NOD mice [PDF]
Nature Medicine, 2000 H A, Runnels, W A, Watkins, J J, Monaco
openaire +6 more sources
Why Is MS a More Frequent Complication of EBV Infection in Females?
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Shannon E. Dunn +2 more
wiley +1 more source
EBV Genome Variations and Association With Diseases
Journal of Medical Virology, Volume 98, Issue 4, April 2026.ABSTRACT The Epstein‐Barr virus (EBV) is associated with a range of diseases, including malignancies and autoimmune disorders. Driven by advances in deep sequencing technologies, recent studies have systematically characterized EBV genomic landscapes in diverse clinical specimens, uncovering distinct geographic patterns in strain distribution. However,
Xueer Lin +5 more
wiley +1 more source
Virology Journal, 2019 Background Haploidentical hematopoietic stem cell transplant (haplo-HSCT) recipients are at high risk for Epstein Barr virus (EBV)-related diseases. EBV-specific CD8+ cytotoxic T cells can control EBV-infected B cell expansion; however, no studies have ...
Ling Zhou, Dao-pei Lu
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BMC Research Notes, 2019 Objective The pre-mRNA of the Epstein–Barr virus LMP2 (latent membrane protein 2) has a region of unusual RNA structure that partially spans two consecutive exons and the entire intervening intron; suggesting RNA folding might affect splicing ...
Nuwanthika Kumarasinghe, Walter N. Moss
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CellsExcessive secretion of pro-inflammatory cytokines leads to the disruption of intestinal barrier in inflammatory bowel disease (IBD). The inflammatory cytokine tumor necrosis factor alpha (TNFα) induces the assembly of the NLRP3 inflammasome, resulting in
Yubin Lee +6 more
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