Results 71 to 80 of about 5,087 (193)

Beyond the Usual Suspects: Emerging Associations Between Epstein‐Barr Virus Infection/Infectious Mononucleosis and Cancers

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT Epstein‐Barr virus (EBV) is a ubiquitous herpesvirus and a causal factor for Burkitt Lymphoma (BL), Hodgkin Lymphoma (HL), gastric carcinoma (GC) and nasopharyngeal carcinoma (NPC). Whether EBV contributes to a wider spectrum of cancers remains uncertain.
Marisa D. Muckian, Graham S. Taylor, John Diaz‐Decaro, Enejda Senko, Helen R. Stagg   +4 more
wiley   +1 more source

Functional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapy.

PLoS ONE, 2007
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignancy with high prevalence in Southern Chinese. In order to assess whether defects of EBV-specific immunity may contribute to the tumor, the phenotype and function of ...
Jiang Li, Xue-hui Zeng, Hao-yuan Mo, Ulrika Rolén, Yan-fang Gao, Xiao-shi Zhang, Qiu-yan Chen, Li Zhang, Mu-sheng Zeng, Man-zhi Li, Wen-lin Huang, Xiao-ning Wang, Yi-xin Zeng, Maria G Masucci   +13 more
doaj   +1 more source

Variable EBV DNA Load Distributions and Heterogeneous EBV mRNA Expression Patterns in the Circulation of Solid Organ versus Stem Cell Transplant Recipients

Clinical and Developmental Immunology, 2012
Epstein-Barr virus (EBV) driven post-transplant lymphoproliferative disease (PTLD) is a heterogeneous and potentially life-threatening condition. Early identification of aberrant EBV activity may prevent progression to B-cell lymphoma.
A. E. Greijer, S. J. Stevens, S. A. Verkuijlen, H. Juwana, S. C. Fleig, E. A. Verschuuren, B. G. Hepkema, J. J. Cornelissen, R. A. Brooimans, L. F. Verdonck, J. M. Middeldorp   +10 more
doaj   +1 more source

LMP2-mRNA lipid nanoparticle sensitizes EBV-related tumors to anti-PD-1 therapy by reversing T cell exhaustion

Journal of Nanobiotechnology, 2023
Background Targeting EBV-proteins with mRNA vaccines is a promising way to treat EBV-related tumors like nasopharyngeal carcinoma (NPC). We assume that it may sensitize tumors to immune checkpoint inhibitors.
Yu Xiang, Miaomiao Tian, Juan Huang, Yueyi Li, Guangqi Li, Xue Li, Zedong Jiang, Xiangrong Song, Xuelei Ma   +8 more
doaj   +1 more source

Why Is MS a More Frequent Complication of EBV Infection in Females?

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Shannon E. Dunn, Nuria Alvarez‐Sanchez, Lawrence Steinman   +2 more
wiley   +1 more source

Additional file 1 of LMP2 and TAP2 impair tumor growth and metastasis by inhibiting Wnt/β-catenin signaling pathway and EMT in cervical cancer

, 2023
Supplemental figures: Supplementary Fig. 1 The relative mRNA levels of Lmp2 and Tap2 were determined by RT-qPCR in LMP2 and TAP2 overexpression (OE) cells. Supplementary Fig.
Zhengyan Cheng (17422289), Jiaxu Li (422143), Xing Chen (140292), Zewei Yang (1562755), Hongbo Wang (587749)   +4 more
core   +1 more source

Distinct Proteasome Subpopulations in the Alveolar Space of Patients with the Acute Respiratory Distress Syndrome

Mediators of Inflammation, 2012
There is increasing evidence that proteasomes have a biological role in the extracellular alveolar space, but inflammation could change their composition.
S. U. Sixt, R. Alami, J. Hakenbeck, M. Adamzik, A. Kloß, U. Costabel, P. R. Jungblut, B. Dahlmann, J. Peters   +8 more
doaj   +1 more source

EBV Genome Variations and Association With Diseases

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT The Epstein‐Barr virus (EBV) is associated with a range of diseases, including malignancies and autoimmune disorders. Driven by advances in deep sequencing technologies, recent studies have systematically characterized EBV genomic landscapes in diverse clinical specimens, uncovering distinct geographic patterns in strain distribution. However,
Xueer Lin, Jingtong Liang, Qiuting Zhang, Qinyao Huang, Xinyu Zhang, Miao Xu   +5 more
wiley   +1 more source

Immunohistochemical Identification and Assessment of the Location of Immunoproteasome Subunits LMP2 and LMP7 in Acquired Cholesteatoma

International Journal of Molecular Sciences, 2023
Cholesteatoma, accompanied by chronic inflammatory response, is characterized by invasive growth and osteolytic activity. As specific proteasome isoforms, the immunoproteasomes serve as an important modulator of inflammatory responses. The aim of the present study was to determine the biological activity of cholesteatoma through the analysis of the ...
Justyna Rutkowska, Irena Kasacka, Marek Rogowski, Ewa Olszewska   +3 more
openaire   +2 more sources

In vivo growth of Epstein-Barr virus transformed B cells with mutations in latent membrane protein 2 (LMP2) [PDF]

, 1997
 Epstein-Barr virus (EBV) causes infectious mononucleosis in adolescents and is associated with malignant B lymphocyte proliferation in AIDS patients, patients undergoing immune suppression for organ transplantation, and SCID mice.
Izumi, K. M., Rochford, Rosemary, Cannon, M. J., Kieff, E., Longnecker, R., Miller, C. L.   +5 more
core   +1 more source