Results 71 to 80 of about 4,438 (169)
Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
LMP2 expression and proteasome activity in NOD mice [PDF]
Nature Medicine, 2000 H A, Runnels, W A, Watkins, J J, Monaco
openaire +6 more sources
Reviews in Medical Virology, Volume 36, Issue 3, May 2026.ABSTRACT Epstein‐Barr virus (EBV) is a ubiquitous herpesvirus and a causal factor for Burkitt Lymphoma (BL), Hodgkin Lymphoma (HL), gastric carcinoma (GC) and nasopharyngeal carcinoma (NPC). Whether EBV contributes to a wider spectrum of cancers remains uncertain.
Marisa D. Muckian +4 more
wiley +1 more source
ACTIVATION MECHANISMS OF GUT-ASSOCIATED LYMPHOID TISSUE UNDER CHRONIC SOCIAL STRESS CONDITIONS
Медицинская иммунология, 2015 Stress-induced immune disregulation is a risk factor of autoimmune and inflammatory diseases, but, so far, the mechanisms for this effect are not fully known. Expression levels of specific mRNAs were assessed in gut-associated lymphoid tissue (GALT) from
A. M. Kamyshnyi, I. A. Topol
doaj +1 more source
BMC Research Notes, 2019 Objective The pre-mRNA of the Epstein–Barr virus LMP2 (latent membrane protein 2) has a region of unusual RNA structure that partially spans two consecutive exons and the entire intervening intron; suggesting RNA folding might affect splicing ...
Nuwanthika Kumarasinghe, Walter N. Moss
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Novel Immunotherapy Options for Extranodal NK/T-Cell Lymphoma
Frontiers in Oncology, 2018 Extranodal NK/T-cell lymphoma (ENKTCL) is a highly aggressive mature NK/T-cell neoplasm marked by NK-cell phenotypic expression of CD3ε and CD56. While the disease is reported worldwide, there is a significant geographic variation with its highest ...
Boyu Hu, Yasuhiro Oki
doaj +1 more source
CellsExcessive secretion of pro-inflammatory cytokines leads to the disruption of intestinal barrier in inflammatory bowel disease (IBD). The inflammatory cytokine tumor necrosis factor alpha (TNFα) induces the assembly of the NLRP3 inflammasome, resulting in
Yubin Lee +6 more
doaj +1 more source
Virology Journal, 2019 Background Haploidentical hematopoietic stem cell transplant (haplo-HSCT) recipients are at high risk for Epstein Barr virus (EBV)-related diseases. EBV-specific CD8+ cytotoxic T cells can control EBV-infected B cell expansion; however, no studies have ...
Ling Zhou, Dao-pei Lu
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The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome
Proceedings of the National Academy of Sciences, 1997 Processing of antigens for presentation by major histocompatibility complex (MHC) class I molecules requires the activity of the proteasome. The 20S proteasome complex is composed of 14 different subunits, 2 of which can be substituted by the interferon γ (IFN-γ)-inducible and MHC-encoded subunits LMP2 and LMP7 (low molecular mass poylpeptides 2 and 7).
M, Groettrup +3 more
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EJC Supplements, 2015 The tumor microenvironment plays an important role in the progression of cancer and may be regulated by proteolysis, including the proteasomes. The proteasomes modify the biologically important molecules involved in the pathogenesis and progression of a ...
E. Shashova +5 more
doaj +1 more source