Military Medical Research, 2021 Background Disruption of the blood–brain barrier (BBB) after a stroke can lead to brain injury and neurological impairment. Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2 (LMP2) in the ...
Xing-Yong Chen +6 more
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Journal of Translational Medicine, 2023 Background Substantial evidence suggests that immunoproteasome is implicated in the various neurological diseases such as stroke, multiple sclerosis and neurodegenerative diseases.
Xingyong Chen +8 more
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Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice. [PDF]
PLoS ONE, 2009 BACKGROUND:Oncocytes of the thyroid gland (Hürthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus.
Hiroaki J Kimura +8 more
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LMP2 polymorphisms and spondyloarthropathies [PDF]
Annals of the Rheumatic Diseases, 1999 Dr Hohler and colleagues1 have examined LMP2 polymorphisms and extraspinal manifestations in spondyloarthropathies arriving at the conclusion that there is no independent association between LMP2 genotypes and the occurrence of uveitis in HLA-B27 positive subjects when stratified for HLA DR.
WALTER P MAKSYMOWYCH, T HÖHLER
openaire +1 more source
Association between plasma immunoproteasome and 90-day prognosis after first-ever ischemic stroke
Neural Regeneration Research, 2021 Many blood biomarkers are reportedly helpful for predicting post-stroke cognitive impairment (PSCI), but no biomarkers are widely used in clinical practice.
Xing-Yong Chen +4 more
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The impact of targeting repetitive BamHI-W sequences on the sensitivity and precision of EBV DNA quantification. [PDF]
PLoS ONE, 2017 Viral load monitoring and early Epstein-Barr virus (EBV) DNA detection are essential in routine laboratory testing, especially in preemptive management of Post-transplant Lymphoproliferative Disorder.
Armen Sanosyan +6 more
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The proteasome system in infection: impact of β5 and LMP7 on composition, maturation and quantity of active proteasome complexes. [PDF]
PLoS ONE, 2012 Proteasomes are the major enzyme complexes for non-lysosomal protein degradation in eukaryotic cells. Mammals express two sets of catalytic subunits: the constitutive subunits β1, β2 and β5 and the immunosubunits LMP2 (β1i), MECL-1 (β2i) and LMP7 (β5i ...
Thorsten Joeris +7 more
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Investigating AKT activation and autophagy in immunoproteasome-deficient retinal cells.
PLoS ONE, 2020 Two major proteolytic systems, the proteasome and the autophagy pathway, are key components of the proteostasis network. The immunoproteasome, a proteasome subtype, and autophagy are upregulated under stress conditions, forming a coordinated unit ...
Md Razaul Karim +4 more
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Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis
Life, 2021 Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk ...
Wanda Niepiekło-Miniewska +6 more
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LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins [PDF]
, 2019 The role of the immunoproteasome is perceived as confined to adaptive immune responses given its ability to produce peptides ideal for MHC Class‐I binding.
Faou, Pierre +10 more
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