Results 31 to 40 of about 4,438 (169)

Los genes TAP y EMP2 en el asma alérgica

Biomédica: revista del Instituto Nacional de Salud, 1997
Los pacientes con asma alérgica presentan una fuerte respuesta de IgE contra los alergenos de ácaros; por tanto, estudiar la inmunogenética de esta respuesta podría ayudar a entender la etiología de las enfermedades alérgicas.
Beatriz Martínez, Luis Caraballo
doaj   +1 more source

The β-carboline Harmine improves the therapeutic benefit of anti-PD1 in melanoma by increasing the MHC-I-dependent antigen presentation

Frontiers in Immunology, 2022
Harmine is a dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor that displays a number of biological and pharmacological properties. Also referred to as ACB1801 molecule, we have previously reported that harmine increases the presentation ...
Muhammad Zaeem Noman, Irene Adelaide Bocci, Manale Karam, Manale Karam, Kris Van Moer, Manon Bosseler, Akinchan Kumar, Guy Berchem, Guy Berchem, Christian Auclair, Christian Auclair, Bassam Janji   +11 more
doaj   +1 more source

Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. [PDF]

PLoS ONE, 2016
The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome.
Haiming M Liu, Deborah A Ferrington, Cory W Baumann, LaDora V Thompson   +3 more
doaj   +1 more source

The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis

Frontiers in Immunology, 2021
Cell survival and function critically relies on the fine-tuned balance of protein synthesis and degradation. In the steady state, the standard proteasome is sufficient to maintain this proteostasis.
Timothy French, Nicole Israel, Nicole Israel, Henning Peter Düsedau, Anne Tersteegen, Johannes Steffen, Clemens Cammann, Clemens Cammann, Eylin Topfstedt, Daniela Dieterich, Daniela Dieterich, Thomas Schüler, Ulrike Seifert, Ulrike Seifert, Ildiko Rita Dunay, Ildiko Rita Dunay   +15 more
doaj   +1 more source

Evaluation of Epstein-Barr Virus Latent Membrane Protein 2 Specific T-Cell Receptors Driven by T-Cell Specific Promoters Using Lentiviral Vector

Clinical and Developmental Immunology, 2011
Transduction of latent membrane protein 2 (LMP2)-specific T-cell receptors into activated T lymphocytes may provide a universal, MHC-restricted mean to treat EBV-associated tumors in adoptive immunotherapy.
Dongchang Yang, Qing Shao, Hua Sun, Xiaoxin Mu, Yun Gao, Runqiu Jiang, Jiajie Hou, Kun Yao, Yun Chen, Beicheng Sun   +9 more
doaj   +1 more source

Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population.

PLoS ONE, 2010
BackgroundAlbeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation.
Michele Mishto, Elena Bellavista, Claudia Ligorio, Kathrin Textoris-Taube, Aurelia Santoro, Mara Giordano, Sandra D'Alfonso, Florinda Listì, Benedetta Nacmias, Elena Cellini, Maurizio Leone, Luigi M E Grimaldi, Chiara Fenoglio, Federica Esposito, Filippo Martinelli-Boneschi, Daniela Galimberti, Elio Scarpini, Ulrike Seifert, Maria Pia Amato, Calogero Caruso, Maria P Foschini, Peter M Kloetzel, Claudio Franceschi   +22 more
doaj   +1 more source

The effect of Epstein-Barr virus Latent Membrane Protein 2 expression on the kinetics of early B cell infection. [PDF]

PLoS ONE, 2013
Infection of human B cells with wild-type Epstein-Barr virus (EBV) in vitro leads to activation and proliferation that result in efficient production of lymphoblastoid cell lines (LCLs). Latent Membrane Protein 2 (LMP2) is expressed early after infection
Laura R Wasil, Monica J Tomaszewski, Aki Hoji, David T Rowe   +3 more
doaj   +1 more source

Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases

Frontiers in Immunology, 2021
Epstein-Barr virus (EBV) is the first human tumor virus discovered and is strongly implicated in the etiology of multiple lymphoid and epithelial cancers.
Xinle Cui, Xinle Cui, Clifford M. Snapper, Clifford M. Snapper   +3 more
doaj   +1 more source

How Strategic Leaders Drive Firms in Ecosystems: Envisioning Value, Orchestrating Knowledge, and Shifting Roles

Journal of Management Studies, EarlyView.
Abstract Research on business ecosystems has illuminated how ecosystems emerge, evolve, and transform, revealing ecosystem‐level dynamics and the central actors that orchestrate them. Yet, it is individual firms that continuously attempt to establish and shift the roles they play within ecosystems through the vision and choices of their strategic ...
Paolo Aversa, Carmelo Cennamo, Ambra Mazzelli, Gianni Lorenzoni   +3 more
wiley   +1 more source

The Accuracy of Plasma EBV-DNA Quantification Using LMP2 as Primer to Detect Distance Metastasis After Radiation of Nasopharyngeal Cancer in “Dharmais” National Cancer Center

Indonesian Journal of Cancer, 2009
Kanker nasofaring (NPC) biasa ditemukan di Indonesia dan berkaitan dengan penyakit tingkat lanjut (advanced disease). Keberadaan virus Epstein-Bar deoxyribonucleic acid (EBV-DNA) sudah lama ditawarkan untuk deteksi awal terhadap kegagalan jarak (distant ...
Dewi Soeis Marzaini, Demak L. Tobing, Siti Boedina Kresno   +2 more
doaj   +1 more source