Journal of Translational Medicine, 2023 Background Substantial evidence suggests that immunoproteasome is implicated in the various neurological diseases such as stroke, multiple sclerosis and neurodegenerative diseases.
Xingyong Chen +8 more
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Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice. [PDF]
PLoS ONE, 2009 BACKGROUND:Oncocytes of the thyroid gland (Hürthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus.
Hiroaki J Kimura +8 more
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Association between plasma immunoproteasome and 90-day prognosis after first-ever ischemic stroke
Neural Regeneration Research, 2021 Many blood biomarkers are reportedly helpful for predicting post-stroke cognitive impairment (PSCI), but no biomarkers are widely used in clinical practice.
Xing-Yong Chen +4 more
doaj +1 more source
Constructing TC-1-GLUC-LMP2 Model Tumor Cells to Evaluate the Anti-Tumor Effects of LMP2-Related Vaccines [PDF]
Viruses, 2018 Epstein-Barr virus (EBV) is related to a variety of malignant tumors, and its encoded protein, latent membrane protein 2 (LMP2), is an effective target antigen that is widely used to construct vector vaccines. However, the model cells carrying LMP2 have still not been established to assess the oncolytic effect of LMP2-related vaccines at present.
Sun, Liying +3 more
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The impact of targeting repetitive BamHI-W sequences on the sensitivity and precision of EBV DNA quantification. [PDF]
PLoS ONE, 2017 Viral load monitoring and early Epstein-Barr virus (EBV) DNA detection are essential in routine laboratory testing, especially in preemptive management of Post-transplant Lymphoproliferative Disorder.
Armen Sanosyan +6 more
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The proteasome system in infection: impact of β5 and LMP7 on composition, maturation and quantity of active proteasome complexes. [PDF]
PLoS ONE, 2012 Proteasomes are the major enzyme complexes for non-lysosomal protein degradation in eukaryotic cells. Mammals express two sets of catalytic subunits: the constitutive subunits β1, β2 and β5 and the immunosubunits LMP2 (β1i), MECL-1 (β2i) and LMP7 (β5i ...
Thorsten Joeris +7 more
doaj +1 more source
Investigating AKT activation and autophagy in immunoproteasome-deficient retinal cells.
PLoS ONE, 2020 Two major proteolytic systems, the proteasome and the autophagy pathway, are key components of the proteostasis network. The immunoproteasome, a proteasome subtype, and autophagy are upregulated under stress conditions, forming a coordinated unit ...
Md Razaul Karim +4 more
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Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis
Life, 2021 Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk ...
Wanda Niepiekło-Miniewska +6 more
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No primary association between LMP2 polymorphisms and extraspinal manifestations in spondyloarthropathies [PDF]
Annals of the Rheumatic Diseases, 1997 To investigate the potential role of the HLA-linked LMP2 (low molecular weight protein) gene polymorphisms in conjunction with DR4 and DR7 on extraspinal disease manifestations in HLA-B27 positive patients with spondyloarthropathy.172 patients with spondyloarthropathy, 46 healthy, HLA-B27 positive blood donors, and 99 unrelated controls were typed for ...
T, Höhler +6 more
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Expression of HPV6b L1/EBV LMP2 multiepitope and immunogenicity in mice [PDF]
Acta Biochimica et Biophysica Sinica, 2010 Human papillomavirus (HPV) major capsid protein L1 is an important vehicle for the delivery of epitopes. To investigate the expression and immunogenicity of hybridized HPV6b L1 containing multiepitope of Epstein-Barr virus (EBV) latency membrane protein 2 (LMP2), a recombinant plasmid pcDNA3.1(+) containing mammalian codon-optimization HPV6b L1 gene ...
Shanli, Zhu +7 more
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