Immunoproteasome inhibition triggers protein stress and apoptosis in cells of B cell lineage without impairing vaccination-induced antibody responses [PDF]
Cell Death DiscoveryThe immunoproteasome (IP) is a specialized form of the 26S proteasome, in which the catalytic subunits β1c, β2c, and β5c of the standard proteasome are replaced by LMP2, MECL-1, and LMP7.
Dennis Mink +7 more
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Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity [PDF]
EMBO reports, 2018 Cells of hematopoietic origin express high levels of the immunoproteasome, a cytokine-inducible proteasome variant comprising the proteolytic subunits LMP2 (β1i), MECL-1 (β2i), and LMP7 (β5i). Targeting the immunoproteasome in pre-clinical models of autoimmune diseases with the epoxyketone inhibitor ONX 0914 has proven to be effective.
Michael Basler +11 more
core +6 more sources
Sinomenine Regulates PSMB9 to Mediate Therapeutic Effects in Rheumatoid Arthritis [PDF]
CellsRheumatoid arthritis (RA) is a systemic immune-related disease characterized by chronic synovial inflammation and progressive joint destruction. However, the molecular mechanisms and diagnostic biomarkers underlying RA remain unclear.
Cui Zhang +4 more
doaj +2 more sources
Correction to "Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema via Activating NRF1/2-P62 Axis and Suppressing IRF4 Transcription". [PDF]
Adv Sci (Weinh)Advanced Science, Volume 13, Issue 11, 23 February 2026.
europepmc +2 more sources
Cross-Species Insights Into Gamma Herpesvirus Transcriptomes: Long-Read and Multi-Omics Perspectives. [PDF]
J Med VirolABSTRACT Comparative transcriptome analyses of gamma herpesviruses have been revolutionized by long‐read sequencing and integrative multi‐omics approaches, enabling unprecedented resolution of viral gene expression. Cross‐species studies of Kaposi's sarcoma‐associated herpesvirus (KSHV), Epstein–Barr virus (EBV), and murine gamma herpesvirus 68 (MHV68)
Shekhar R +4 more
europepmc +2 more sources
Latent, Lytic, and Linked to Multiple Sclerosis-How EBV Drives Autoimmunity. [PDF]
Eur J ImmunolEBV latent and lytic genes uniquely contribute to Multiple Sclerosis development by various immunopathogenic mechanisms in susceptible hosts. Briefly, EBV infection shapes the B‐cell repertoire and promotes the oligoclonal expansion and subsequent CNS infiltration of T‐bet+CXCR3+ B cells, resulting in a cascade of immune dysregulation, CNS inflammation,
Läderach F, Bremer E, Münz C.
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Targeting intracellular LMP2 with costimulatory signal–armed antibody-like TCR T cells [PDF]
JCI InsightExpanding the repertoire of CAR therapies to include intracellular antigens holds promise for treating a broad spectrum of malignancies. TCR-like T cells, capable of recognizing intracellular antigen–derived peptides in complex with HLA molecules (pHLA),
Jiali Cheng +18 more
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Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma [PDF]
Journal of Virology, 1992 Two species of the Epstein-Barr virus-encoded latent membrane protein 2, LMP2A and LMP2B, are generated by alternative splicing, each species having a distinct first exon. LMP2 transcription in undifferentiated nasopharyngeal carcinoma (NPC), which is consistently associated with the Epstein-Barr virus, was investigated.
P, Busson +5 more
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Selected Contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis
Journal of Applied Physiology, 2001 Recent results in an animal model of autoimmune diabetes, the nonobese diabetic (NOD) mouse, suggest a hypothesis to explain the role of major histocompatibility complex (MHC) in autoimmunity. The genome MHC region contains immune response genes that are important for T cell education and antigen presentation by MHC molecules.
T, Hayashi, D L, Faustman
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Specific Immune Responses and Oncolytic Effects Induced by EBV LMP2A-Armed Modified Ankara-Vaccinia Virus Vectored Vaccines in Nasopharyngeal Cancer [PDF]
PharmaceuticsBackground: The Epstein-Barr virus (EBV) is intricately linked to a range of human malignancies, with EBV latent membrane protein 2A (LMP2A) emerging as a potential target antigen for immunotherapeutic strategies in the treatment of nasopharyngeal ...
Liying Sun, Chao Liu, Junping Peng
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