Results 21 to 30 of about 4,438 (169)

The proteasome system in infection: impact of β5 and LMP7 on composition, maturation and quantity of active proteasome complexes. [PDF]

PLoS ONE, 2012
Proteasomes are the major enzyme complexes for non-lysosomal protein degradation in eukaryotic cells. Mammals express two sets of catalytic subunits: the constitutive subunits β1, β2 and β5 and the immunosubunits LMP2 (β1i), MECL-1 (β2i) and LMP7 (β5i ...
Thorsten Joeris, Nicole Schmidt, David Ermert, Petra Krienke, Alexander Visekruna, Ulrike Kuckelkorn, Stefan H E Kaufmann, Ulrich Steinhoff   +7 more
doaj   +1 more source

Investigating AKT activation and autophagy in immunoproteasome-deficient retinal cells.

PLoS ONE, 2020
Two major proteolytic systems, the proteasome and the autophagy pathway, are key components of the proteostasis network. The immunoproteasome, a proteasome subtype, and autophagy are upregulated under stress conditions, forming a coordinated unit ...
Md Razaul Karim, Cody R Fisher, Rebecca J Kapphahn, Jorge R Polanco, Deborah A Ferrington   +4 more
doaj   +1 more source

Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis

Life, 2021
Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk ...
Wanda Niepiekło-Miniewska, Łukasz Matusiak, Joanna Narbutt, Alekandra Lesiak, Piotr Kuna, Andrzej Wiśniewski, Piotr Kuśnierczyk   +6 more
doaj   +1 more source

No primary association between LMP2 polymorphisms and extraspinal manifestations in spondyloarthropathies [PDF]

Annals of the Rheumatic Diseases, 1997
To investigate the potential role of the HLA-linked LMP2 (low molecular weight protein) gene polymorphisms in conjunction with DR4 and DR7 on extraspinal disease manifestations in HLA-B27 positive patients with spondyloarthropathy.172 patients with spondyloarthropathy, 46 healthy, HLA-B27 positive blood donors, and 99 unrelated controls were typed for ...
T, Höhler, T, Schäper, P M, Schneider, F, Krummenauer, C, Rittner, K H, Meyer zum Büschenfelde, E, Märker-Hermann   +6 more
openaire   +2 more sources

Expression of HPV6b L1/EBV LMP2 multiepitope and immunogenicity in mice [PDF]

Acta Biochimica et Biophysica Sinica, 2010
Human papillomavirus (HPV) major capsid protein L1 is an important vehicle for the delivery of epitopes. To investigate the expression and immunogenicity of hybridized HPV6b L1 containing multiepitope of Epstein-Barr virus (EBV) latency membrane protein 2 (LMP2), a recombinant plasmid pcDNA3.1(+) containing mammalian codon-optimization HPV6b L1 gene ...
Shanli, Zhu, Xiangyang, Xue, Jianxiao, Liu, Lijun, Lu, Pengyun, Zhao, Jia, Wang, WenShu, Li, Lifang, Zhang   +7 more
openaire   +2 more sources

LMP2 and LMP7 gene polymorphism in Mexican populations: Mestizos and Amerindians [PDF]

Genes & Immunity, 2002
Low molecular weight polypeptide (LMP) genes are located within the major histocompatibility complex and have been associated with autoimmune diseases such as ankylosing spondylitis. In order to define the distribution of LMP genes in Mexican populations, the LMP2 and LMP7 polymorphism was analyzed in 312 Mexican individuals (95 Mexican Mestizos, 48 ...
G, Vargas-Alarcón, R, Gamboa, Y, Vergara, J M, Rodriguez-Zepeda, A, de la Peña, R, Izaguirre, J, Zuñiga, J A, Ruiz-Morales, J, Granados   +8 more
openaire   +2 more sources

Molecular Mechanisms of Uterine Leiomyosarcomas: Involvement of Defect in LMP2 Expression [PDF]

Gene Regulation and Systems Biology, 2008
Patients with uterine leiomyosarcoma (LMS) typically present with vaginal bleeding, pain, and a pelvic mass. Typical presentations with hypercalcemia or eosinophilia have been reported. Radiographic evaluation with combined positron emission tomography/computed tomography may assist in the diagnosis and surveillance of women with uterine LMS.
Takuma, Hayashi, Yuto, Shimamura, Taro, Saegusa, Akiko, Horiuchi, Yukihiro, Kobayashi, Nobuyoshi, Hiraoka, Yae, Kanai, Hiroyuki, Aburatani, Kenji, Sano, Ikuo, Konishi   +9 more
openaire   +2 more sources

Reduced Expression of the Antigen Processing Machinery Components TAP2, LMP2, and LMP7 in Tonsillar and Base of Tongue Cancer and Implications for Clinical Outcome

Translational Oncology, 2015
OBJECTIVES: Patients with human papillomavirus (HPV)–positive tonsillar squamous cell carcinoma (TSCC) and base of tongue squamous cell carcinoma (BOTSCC) have a better clinical outcome than those with corresponding HPV-negative tumors.
Nikolaos Tertipis, Linnea Haeggblom, Nathalie Grün, Cecilia Nordfors, Anders Näsman, Tina Dalianis, Torbjörn Ramqvist   +6 more
doaj   +1 more source

Application of Explicitly Localized Molecular Orbitals to Electronic Structure Calculations

CHIMIA, 2012
We have recently generalized the method for localizing orbitals on a set of predefined molecular fragments [Phys. Chem. Chem. Phys. 2012, 14, 546].
Piotr de Silva, Marcin Makowski, Jacek Korchowiec   +2 more
doaj   +1 more source

'Off-the-shelf’ allogeneic antigen-specific adoptive T-cell therapy for the treatment of multiple EBV-associated malignancies

Journal for ImmunoTherapy of Cancer, 2021
Background Epstein-Barr virus (EBV), an oncogenic human gammaherpesvirus, is associated with a wide range of human malignancies of epithelial and B-cell origin.
Debottam Sinha, Sriganesh Srihari, Kirrliee Beckett, Laetitia Le Texier, Matthew Solomon, Archana Panikkar, George R Ambalathingal, Lea Lekieffre, Pauline Crooks, Sweera Rehan, Michelle A. Neller, Corey Smith, Rajiv Khanna   +12 more
doaj   +1 more source