Results 101 to 110 of about 2,423 (198)

Innate immune responses against P. yoelii in LMP7-deficient mice.

, 2013
(A) Splenic CD11c+ dendritic cells obtained from WT (upper panels) and LMP7-deficient mice (lower panels) 5 days after infection were analyzed for their expression of activation markers.
Makoto Hirai (227542), Hiroko Okada (391891), Hajime Hisaeda (391893), Liping Tu (391888), Kazutomo Suzue (115420), Bin Chou (391887), Chikako Shimokawa (391892), Tomoyo Taniguchi (391890), Takashi Imai (24800), Kunisuke Himeno (391889), Xuefeng Duan (391886)   +10 more
core   +1 more source

Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice

, 2017
New treatment options and drug targets for colorectal carcinoma are a pressing medical need. Inflammation and pro-inflammatory cytokines produced by Th1 and Th17 cells like IL-6, TNF, IL-17 and IL-23 promote the development and growth of colorectal ...
Thomas Brunner, Julia Koerner, Brunner, Thomas, Körner, Julia, Marcus Groettrup, Koerner, Julia, Groettrup, Marcus   +6 more
core   +1 more source

Relative quantification of proteasome maturation in lmp7^−/− Mefs expressing proLMP7- or proβ5-containing subunits.

, 2012
(A) lmp7−/− Mefs expressing the proLMP7-containing subunits LMP7-Flag and proLMP7mβ5-Flag or the proβ5-containing subunits β5-Flag and proβ5mLMP7-Flag were either left unstimulated or cultured in the presence of 50 U/ml IFNγ for 4 days.
Nicole Schmidt (154421), Ulrich Steinhoff (154431), Stefan H. E. Kaufmann (149315), Petra Krienke (154424), Alexander Visekruna (154426), Ulrike Kuckelkorn (154428), David Ermert (154423), Thorsten Joeris (154419)   +7 more
core   +1 more source

Efficiency of bacterial killing is unaltered in β5i/LMP7^-/- leukocytes.

, 2016
(A) Analysis of phagocytosis of fluorochrome-labelled particles by BMM, determined by flow cytometry (each group with n = 3). (B) Analysis of the intracellular early phase of killing and (C) late phase of killing of D39Δcps by BMM. Therefore, BMM were co-
Peter-Michael Kloetzel (410911), Martin Witzenrath (167419), Felicia Kirschner (2622049), Katrin Reppe (599647), Nadine Andresen (2622046), Frédéric Ebstein (528304)   +5 more
core   +1 more source

The role of immunoproteasome subunit LMP7 in modulating T-helper cell differentiation and progression of autoimmune diseases

, 2013
The Proteasome is the central proteolytic machinery in cells, which plays an important role in antigen processing. The processing of the antigens is done by the catalytic active sites present in the inner -ring of the 20S core subunit of the proteasome ...
Kalim, Khalid W.
core   +1 more source

Autoimmune reactivity against the 20S-proteasome includes immunosubunits LMP2 (beta 1i), MECL1 (beta 2i) and LMP7 (beta 5i)

, 2008
Objectives. Autoantibodies against the 20S-proteasome display a broad diversity with a remarkably low frequency of individual cross-reactivity against the different subunits of the proteasome. Although their pathogenic and diagnostic significance remains
Egerer, K., Feist, E., Scheffler, S., Reiter, K., Soza, A., Burmester, G. R., Kuckelkorn, U., Doerner, T.   +7 more
core   +1 more source

Expression of immunoproteasome in murine corneal epithelium.

, 2013
(A) Immunostaining with anti-Lmp7 antibody in WT corneal sections showed expression of immunoproteasome. Negative controls included staining with secondary antibody only (WT) and staining with anti-Lmp7 in immunoproteasome knock-out mice (L7M1).
Angela A. Chang (287399), Abrar A. Rageh (287403), Craig W. Huang (287401), Elizabeth F. Nelson (287404), Neal D. Heuss (263583), Marcela Maldonado (282241), Deborah A. Ferrington (282245), Wendy Bratten (287402), Ching Yuan (282244), Heidi Roehrich (287398), Dale S. Gregerson (263587)   +10 more
core   +1 more source

Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages.

, 2016
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes involved in shaping adaptive immune responses, but their role in innate immune ...
Yu, Y., Meiners, S., M Irmler, Eickelberg, O., Y Yu, Y Wu, O Vosyka, Beckers, J., Vosyka, O., Baumann, T., Wu, Y., S Chen, Overkleeft, H.S., T Baumann, J Beckers, Stöger, T., Irmler, M., T Stoeger, Stoeger, T., Chen, S., O Eickelberg, H S Overkleeft, Kammerl, I.E., S Meiners, I E Kammerl   +24 more
core   +1 more source

UEG Week 2024 Moderated Posters

United European Gastroenterology Journal, Volume 12, Issue S8, Page 201-664, October 2024.
wiley   +1 more source

Confocal images of cells in slices of IDC after double immunofluorescent labeling.

, 2014
(Panel A) Rabbit pAbs to LMP7 subunit and mouse mAbs to α1,2,3,5,6,7 subunits. (Panel B) Rabbit pAbs to LMP7 subunit and mouse mAbs to Rpt6 subunit. IDC, invasive ductal carcinoma. Scale bar, 100 µm.
Elena M. Slonimskaya (646538), Irina V. Kondakova (646542), Olga V. Savenkova (646539), Nikolay G. Gornostaev (646541), Alexey M. Kulikov (646540), Yulia V. Lyupina (646536), Elena E. Shashova (646535), Svetlana A. Glushchenko (646537), Natalia P. Sharova (646543)   +8 more
core   +1 more source