Results 71 to 80 of about 1,819 (163)

Proteasome composition in immune cells implies special immune‐cell‐specific immunoproteasome function

European Journal of Immunology, Volume 54, Issue 4, April 2024.
Immune cells from human peripheral blood and immune cells from murine spleen have been analyzed for their proteasome composition. All analyzed immune populations express almost solely immunoproteasome subunits and rather small proportions of standard proteasome subunits.
Katharina Inholz, Janet L. Anderl, Moritz Klawitter, Heike Goebel, Elmer Maurits, Christopher J. Kirk, R. Andrea Fan, Michael Basler   +7 more
wiley   +1 more source

Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma

Scientific Reports, 2017
Merkel cell carcinoma (MCC) is a rare and aggressive, yet highly immunogenic skin cancer. The latter is due to its viral or UV-associated carcinogenesis. For tumor progression MCC has to escape the host’s immuno-surveillance, e.g.
Cathrin Ritter, Kaiji Fan, Annette Paschen, Sine Reker Hardrup, Soldano Ferrone, Paul Nghiem, Selma Ugurel, David Schrama, Jürgen C. Becker   +8 more
doaj   +1 more source

LMP2 and LMP7 Gene Polymorphisms in the Southeastern Anatolia Population of Turkey

INTERNATIONAL JOURNAL OF HUMAN GENETICS, 2013
The low molecular weight polypeptide 2 (LMP2) and low molecular weight polypeptide 7 (LMP7) genes are located in the class II region of the Major Histocompatability Complex (MHC) locus on chromosome 6. These genes encode peptides forming the large components of the proteosome complex which degrades short-lived cytoplasmic proteins.
openaire   +1 more source

IRF‐1 mediates upregulation of LMP7 by IFN‐γ and concerted expression of immunosubunits of the proteasome

FEBS Letters, 2005
An immunoproteasome subunit low molecular weight protein 7 (LMP7) plays critical roles in major histocompatibility complex class I antigen processing; however, the mechanism for its expression has remained unclear. We demonstrate that interferon (IFN) regulatory factor‐1 (IRF‐1) has a pivotal role in IFN‐γ‐dependent LMP7 expression, as was shown for ...
Namiki, Shin, Nakamura, Tetsuya, Oshima, Shigeru, Yamazaki, Motomi, Sekine, Yuko, Tsuchiya, Kiichiro, Okamoto, Ryuichi, Kanai, Takanori, Watanabe, Mamoru   +8 more
openaire   +2 more sources

A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus.

PLoS ONE, 2011
Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates and immunocompromised adults.
Sarah Hutchinson, Stuart Sims, Geraldine O'Hara, Jon Silk, Uzi Gileadi, Vincenzo Cerundolo, Paul Klenerman   +6 more
doaj   +1 more source

Characterization of the immunproteasome subunits LMP2 and LMP7 in the mouse brain

, 2018
Die hier verfasste Dissertation beinhaltet eine Lokalisationsstudie sowie eine funktionelle Charakterisierung der katalytischen Untereinheiten LMP2 und LMP7 des Immunoproteasomes (IPs) im Gehirn der Maus. Das IP ist eine spezifische Form des Proteasoms, welches konstitutiv in Zellen des Immunsystems exprimiert wird und auf Grund seiner speziellen ...
openaire   +2 more sources

Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models

Lipids in Health and Disease, 2011
Background Inflammation has been implicated in a variety of diseases associated with ageing, including cancer, cardiovascular, and neurologic diseases.
Papasian Christopher J, Badr Mostafa Z, Reis Julia C, Tan Xiaoyu, Qureshi Asaf A, Morrison David C, Qureshi Nilofer   +6 more
doaj   +1 more source

Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic cat.

PLoS ONE, 2008
Two sequences of major histocompatibility complex (MHC) regions in the domestic cat, 2.976 and 0.362 Mbps, which were separated by an ancient chromosome break (55-80 MYA) and followed by a chromosomal inversion were annotated in detail.
Naoya Yuhki, James C Mullikin, Thomas Beck, Robert Stephens, Stephen J O'Brien   +4 more
doaj   +1 more source

Inhibition of Immunoproteasome Attenuates NLRP3 Inflammasome Response by Regulating E3 Ubiquitin Ligase TRIM31

Cells
Excessive secretion of pro-inflammatory cytokines leads to the disruption of intestinal barrier in inflammatory bowel disease (IBD). The inflammatory cytokine tumor necrosis factor alpha (TNFα) induces the assembly of the NLRP3 inflammasome, resulting in
Yubin Lee, Boran Yoon, Sumin Son, Eunbin Cho, Kyung Bo Kim, Eun Young Choi, Dong-Eun Kim   +6 more
doaj   +1 more source

EXPRESSION OF GENES ENCODING IMMUNOPROTEASOME SUBUNITS INDUCIBLE BY MACROPHAGES INFECTED WITH M. bovis BGC AND M. Tuberculosis H37RV

Туберкулез и болезни лёгких, 2014
To study the effect of M. bovis BCG vaccine strain and virulent laboratory M. tuberculosis H37Rv strain on the expression of macrophageinducible immunoproteasome subunits, a real-time reverse-transcription polymerase chain reaction technique using cDNA ...
S. N. Andreevskaya, T. G. Smirnova, A. V. Timofeev, E. E. Larionova, L. N. Chernousova   +4 more
doaj