Results 71 to 80 of about 2,385 (193)

The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire

, 2017
Cells of hematopoietic origin express high levels of the immunoproteasome, a cytokine-inducible variant of the proteasome which has been implicated in regulating inflammatory responses and antigen presentation.
Mundt, Sarah, Gröttrup, Marcus, Michael Basler, Marcus Groettrup, Sarah Mundt, Basler, Michael   +5 more
core   +1 more source

Piplartine as an Innovative Natural Product With Dual Antiparasitic and Immunomodulatory Actions

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Neglected tropical diseases (NTDs) remain a major global health burden, disproportionately affecting low‐ and middle‐income regions and demanding innovative therapeutic strategies. This review summarizes current evidence on piplartine (piperlongumine), a naturally occurring amide from Piper species with broad antiparasitic and immunomodulatory ...
Lucas Fukui-Silva, Felipe C. R. de Souza, Camila S. Amorim, Josué de Moraes, Poorani Gurumallesh Prabu   +4 more
wiley   +1 more source

Pluripotent stem cell‐based screening identifies CUDC‐907 as an effective compound for restoring the in vitro phenotype of Nakajo‐Nishimura syndrome

Stem Cells Translational Medicine, 2021
Nakajo‐Nishimura syndrome (NNS) is an autoinflammatory disorder caused by a homozygous mutations in the PSMB8 gene. The administration of systemic corticosteroids is partially effective, but continuous treatment causes severe side effects.
Naoya Kase, Madoka Terashima, Akira Ohta, Akira Niwa, Fumiko Honda‐Ozaki, Yuri Kawasaki, Tatsutoshi Nakahata, Nobuo Kanazawa, Megumu K. Saito   +8 more
doaj   +1 more source

Targeted Therapy for Idiopathic Inflammatory Myopathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune disorders characterized by chronic muscle inflammation and significant extramuscular involvement. A substantial proportion of patients exhibit refractory or relapsing disease despite conventional immunosuppressive therapies, necessitating the ...
Ruijie Wang, Wei Lin, Qibing Xie, Geng Yin   +3 more
wiley   +1 more source

Proteasome functioning in breast cancer: connection with clinical-pathological factors. [PDF]

PLoS ONE, 2014
Breast cancer is one of four oncology diseases that are most widespread in the world. Moreover, breast cancer is one of leading causes of cancer-related deaths in female population within economically developed regions of the world.
Elena E Shashova, Yulia V Lyupina, Svetlana A Glushchenko, Elena M Slonimskaya, Olga V Savenkova, Alexey M Kulikov, Nikolay G Gornostaev, Irina V Kondakova, Natalia P Sharova   +8 more
doaj   +1 more source

Proteomic Profiling Informs Mechanisms of Esophageal Adenocarcinoma Inhibition by Cranberry Proanthocyanidins

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang, Michelle Lee, Erika de Jesus, Katherine Weh, Connor Howard, Henriette Remmer, Amy B. Howell, Laura A. Kresty   +7 more
wiley   +1 more source

Heat Shock Up-Regulates lmp2 and lmp7 and Enhances Presentation of Immunoproteasome-Dependent Epitopes [PDF]

The Journal of Immunology, 2006
Abstract The heat shock response is a canonical regulatory pathway by which cellular stressors such as heat and oxidative stress alter the expression of stress-responsive genes. Some of these stress-responsive genes (heat shock proteins and MHC class I (MHC I)-related chains) play a significant role in the immune system. In this study,
Margaret K, Callahan, Elizabeth A, Wohlfert, Antoine, Ménoret, Pramod K, Srivastava   +3 more
openaire   +2 more sources

Methylation levels of TAP1, TAP2, LMP7, tapasin and ERp57 in CIN and CSCC samples.

, 2012
Methylation levels of TAP1, TAP2, LMP7, tapasin and ERp57 in CIN and CSCC samples.
Ting Wang (16292), Jun-Qi Ma (135472), Zhen Jiao (135475), Gulzareye Akula (135478), Abulizi Abudula (135482), Reshalaiti Aimiduo (135469), Ayshamgul Hasim (135464), Mangnishahan Abudula (135466)   +7 more
core   +1 more source

Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers [PDF]

Cancer Research and Treatment, 2019
In the presence of interferon, proteasome subunits are replaced by their inducible counterparts to form an immunoproteasome (IP) plays a key role in generation of antigenic peptides presented by MHC class I molecules, leading to elicitation of a T cell‒mediated immune response.
Lee, Miseon, Song, In Hye, Heo, Sun-Hee, Kim, Young-Ae, Park, In Ah, Bang, Won Seon, Park, Hye Seon, Gong, Gyungyub, Lee, Hee Jin   +8 more
openaire   +2 more sources

Susceptibility of RBCs from LMP7-deficient mice infected with PyL to phagocytosis by macrophages.

, 2013
(A) Peritoneal macrophages obtained from WT mice were cultured with CFSE-labeled nRBCs and pRBCs prepared from WT or LMP7-deficient mice as in Fig. 3B. Phagocytosing macrophages were determined as in Fig. 3B.
Makoto Hirai (227542), Hiroko Okada (391891), Hajime Hisaeda (391893), Liping Tu (391888), Kazutomo Suzue (115420), Bin Chou (391887), Chikako Shimokawa (391892), Tomoyo Taniguchi (391890), Takashi Imai (24800), Kunisuke Himeno (391889), Xuefeng Duan (391886)   +10 more
core   +1 more source