Results 71 to 80 of about 2,423 (198)
Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation. [PDF]
PLoS ONE, 2013 Alcohol binge-drinking (acute ethanol consumption) is immunosuppressive and alters both the innate and adaptive arms of the immune system. Antigen presentation by macrophages (and other antigen presenting cells) represents an important function of the ...
Alain J D'Souza +5 more
doaj +1 more source
Hiding in Plain Sight: A Case of Intestinal Tuberculosis Masquerading as Benign Lower GI Bleeding
Case Reports in Gastrointestinal Medicine, Volume 2026, Issue 1, 2026.Background Intestinal tuberculosis (TB) represents the most common form of abdominal TB, often affecting the ileocaecal region. Lower gastrointestinal bleeding is an uncommon presentation and may create significant diagnostic uncertainty, particularly in immunocompromised patients and in settings where inflammatory bowel disease is also encountered ...
Lavender Otom +7 more
wiley +1 more source
Journal of Immunology Research, Volume 2026, Issue 1, 2026.Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality worldwide. Approximately 15% of localized and 5% of metastatic cases exhibit mismatch repair deficiency (dMMR) or high microsatellite instability (MSI‐H). While immune checkpoint inhibitors (ICIs) have revolutionized the first‐line treatment for this subgroup, 15%–46% of ...
Ke Zhou +4 more
wiley +1 more source
Piplartine as an Innovative Natural Product With Dual Antiparasitic and Immunomodulatory Actions
Journal of Immunology Research, Volume 2026, Issue 1, 2026.Neglected tropical diseases (NTDs) remain a major global health burden, disproportionately affecting low‐ and middle‐income regions and demanding innovative therapeutic strategies. This review summarizes current evidence on piplartine (piperlongumine), a naturally occurring amide from Piper species with broad antiparasitic and immunomodulatory ...
Lucas Fukui-Silva +4 more
wiley +1 more source
Stem Cells Translational Medicine, 2021 Nakajo‐Nishimura syndrome (NNS) is an autoinflammatory disorder caused by a homozygous mutations in the PSMB8 gene. The administration of systemic corticosteroids is partially effective, but continuous treatment causes severe side effects.
Naoya Kase +8 more
doaj +1 more source
Targeted Therapy for Idiopathic Inflammatory Myopathy
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.ABSTRACT Background Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune disorders characterized by chronic muscle inflammation and significant extramuscular involvement. A substantial proportion of patients exhibit refractory or relapsing disease despite conventional immunosuppressive therapies, necessitating the ...
Ruijie Wang +3 more
wiley +1 more source
, 2010 BACKGROUND AND AIMS: Inflammatory bowel disease (IBD), comprising Crohn s disease and ulcerative colitis, is characterised by chronic relapsing inflammation of the gut.
Schmidt, N;Gonzalez, E;Visekruna, A;Kuhl, AA;Loddenkemper, C;Mollenkopf, H;Kaufmann, SH;Steinhoff, U;Joeris, T
core +1 more source
Proteasome functioning in breast cancer: connection with clinical-pathological factors. [PDF]
PLoS ONE, 2014 Breast cancer is one of four oncology diseases that are most widespread in the world. Moreover, breast cancer is one of leading causes of cancer-related deaths in female population within economically developed regions of the world.
Elena E Shashova +8 more
doaj +1 more source
Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang +7 more
wiley +1 more source
, 2020 Relationship between age and intensity of immunohistochemical reaction in the man’s heart: Immunoreaction against β-catenin in intercalated discs (A), immunoreaction against β-catenin in cardiomyocytes cytoplasm (B), immunoreaction against CacyBP/SIP in ...
Irena Kasacka (8520003) +4 more
core +1 more source