Results 51 to 60 of about 2,385 (193)

Co-immunoprecipitation analysis using proβ5- and LMP7-containing proteasome subunits over-expressed in lmp7^−/−Mefs.

, 2012
Flag-tagged full-length LMP7 (LMP7-Flag), proLMP7 fused to mature β5 (proLMP7mβ5-Flag), full-length β5 (β5-Flag) and proβ5 fused to mature LMP7 (proβ5mLMP7-Flag) were over-expressed in lmp7−/−Mefs by retroviral transduction (A).
Nicole Schmidt (154421), Ulrich Steinhoff (154431), Stefan H. E. Kaufmann (149315), Petra Krienke (154424), Alexander Visekruna (154426), Ulrike Kuckelkorn (154428), David Ermert (154423), Thorsten Joeris (154419)   +7 more
core   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Turning Cold Tumors Into Hot Tumors: Implications for Cancer Therapy

MedComm, Volume 7, Issue 8, August 2026.
Barrier‐defined strategies for cold‐to‐hot tumor conversion. Cold tumors include immune‐desert and immune‐excluded states marked by poor antigen visibility, limited T‐cell priming, stromal or vascular exclusion, metabolic stress and suppressive immune programs.
Xiao Ge, Dong Han, Jing Wang, Xinyu Dai, Chen Ma, Feihong Chen   +5 more
wiley   +1 more source

Interferon y Stimulation Modulates the Proteolytic Activity and Cleavage Site Preference of 20S Mouse Proteasomes [PDF]

, 1994
The proteasome is a 700-kD multisubunit enzyme complex with several proteolytically active sites. The enzyme complex is involved in both ubiquitin-dependent and -independent protein degradation and may contribute to the processing of antigens presented ...
Multhaupt, Gerd, Koszinowski, Ulrich H., Kloetzel, Peter-M., Boes, Bettina, Ruppert, Thomas, Hengel, Hartmut   +5 more
core   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

Distinct Proteasome Subpopulations in the Alveolar Space of Patients with the Acute Respiratory Distress Syndrome

Mediators of Inflammation, 2012
There is increasing evidence that proteasomes have a biological role in the extracellular alveolar space, but inflammation could change their composition.
S. U. Sixt, R. Alami, J. Hakenbeck, M. Adamzik, A. Kloß, U. Costabel, P. R. Jungblut, B. Dahlmann, J. Peters   +8 more
doaj   +1 more source

ONX 0914 Lacks Selectivity for the Cardiac Immunoproteasome in CoxsackievirusB3 Myocarditis of NMRI Mice and Promotes Virus-Mediated Tissue Damage

Cells, 2020
Inhibition of proteasome function by small molecules is highly efficacious in cancer treatment. Other than non-selective proteasome inhibitors, immunoproteasome-specific inhibitors allow for specific targeting of the proteasome in immune cells and the ...
Hannah Louise Neumaier, Shelly Harel, Karin Klingel, Ziya Kaya, Arnd Heuser, Meike Kespohl, Antje Beling   +6 more
doaj   +1 more source

Activity of immunoproteasome inhibitor ONX-0914 in acute lymphoblastic leukemia expressing MLL–AF4 fusion protein

Scientific Reports, 2021
Proteasome inhibitors bortezomib and carfilzomib are approved for the treatment of multiple myeloma and mantle cell lymphoma and have demonstrated clinical efficacy for the treatment of acute lymphoblastic leukemia (ALL). The t(4;11)(q21;q23) chromosomal
Tyler W. Jenkins, Sondra L. Downey-Kopyscinski, Jennifer L. Fields, Gilbert J. Rahme, William C. Colley, Mark A. Israel, Andrey V. Maksimenko, Steven N. Fiering, Alexei F. Kisselev   +8 more
doaj   +1 more source

Single‐Cell RNA Sequencing Revealed the Role of Interferon‐Gamma Related Genes in Primary Sjögren's Syndrome

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder. Dysregulated interferon‐gamma (IFN‐γ) signalling is implicated in pSS pathogenesis, yet the underlying mechanisms remain elusive. This study aimed to identify key IFN‐γ‐associated diagnostic genes and delineate their roles in immune dysregulation using peripheral blood ...
Lei Shi, Tian‐chi Wei, Jing Zhang
wiley   +1 more source

The LMP7-K Allele of the Immunoproteasome Exhibits Reduced Transcript Stability and Predicts High Risk of Colon Cancer

, 2011
Destruction of cancer cells by cytotoxic T lymphocytes depends on immunogenic tumor peptides generated by proteasomes and presented by human leukocyte antigen (HLA) molecules.
Andreas G. Nerlich, Rudolf Wank, Barbara Fellerhoff, Reinhard Kopp, Judith P. Johnson, Barbara Laumbacher, Songhai Gu, Elisabeth H. Weiss, Jürgen Glas   +8 more
core   +1 more source