Results 11 to 20 of about 1,819 (163)

Immunohistochemical Identification and Assessment of the Location of Immunoproteasome Subunits LMP2 and LMP7 in Acquired Cholesteatoma [PDF]

International Journal of Molecular Sciences, 2023
Cholesteatoma, accompanied by chronic inflammatory response, is characterized by invasive growth and osteolytic activity. As specific proteasome isoforms, the immunoproteasomes serve as an important modulator of inflammatory responses. The aim of the present study was to determine the biological activity of cholesteatoma through the analysis of the ...
Irena Kasacka, Marek Rogowski, Ewa Olszewska   +2 more
exaly   +4 more sources

Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection

Scientific Reports, 2022
Immunoproteasomes (IP) serve as an important modulator of immune responses to pathogens and other pathological factors. LMP7/β5i, one of the IP subunits, plays a critical role in autoimmune diseases by downregulating inflammation.
Kris Genelyn Dimasuay, Niccolette Schaunaman, Bruce Berg, Diana Cervantes, Elke Kruger, Frank L. Heppner, Deborah A. Ferrington, Hong Wei Chu   +7 more
doaj   +3 more sources

Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice. [PDF]

PLoS ONE, 2013
General cellular functions of proteasomes occur through protein degradation, whereas the specific function of immunoproteasomes is the optimization of antigen processing associated with MHC class I.
Xuefeng Duan, Takashi Imai, Bin Chou, Liping Tu, Kunisuke Himeno, Kazutomo Suzue, Makoto Hirai, Tomoyo Taniguchi, Hiroko Okada, Chikako Shimokawa, Hajime Hisaeda   +10 more
doaj   +4 more sources

The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis [PDF]

Frontiers in Immunology, 2021
Cell survival and function critically relies on the fine-tuned balance of protein synthesis and degradation. In the steady state, the standard proteasome is sufficient to maintain this proteostasis.
Timothy French, Nicole Israel, Nicole Israel, Henning Peter Düsedau, Anne Tersteegen, Johannes Steffen, Clemens Cammann, Clemens Cammann, Eylin Topfstedt, Daniela Dieterich, Daniela Dieterich, Thomas Schüler, Ulrike Seifert, Ulrike Seifert, Ildiko Rita Dunay, Ildiko Rita Dunay   +15 more
doaj   +3 more sources

Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.

PLoS Pathogens, 2011
Proteasomes recognize and degrade poly-ubiquitinylated proteins. In infectious disease, cells activated by interferons (IFNs) express three unique catalytic subunits β1i/LMP2, β2i/MECL-1 and β5i/LMP7 forming an alternative proteasome isoform, the ...
Elisa Opitz, Annett Koch, Karin Klingel, Frank Schmidt, Stefan Prokop, Anna Rahnefeld, Martina Sauter, Frank L Heppner, Uwe Völker, Reinhard Kandolf, Ulrike Kuckelkorn, Karl Stangl, Elke Krüger, Peter M Kloetzel, Antje Voigt   +14 more
doaj   +4 more sources

Immunoproteasome subunit ß5i/LMP7-deficiency in atherosclerosis [PDF]

Scientific Reports, 2017
AbstractManagement of protein homeostasis by the ubiquitin-proteasome system is critical for atherosclerosis development. Recent studies showed controversial results on the role of immunoproteasome (IP) subunit β5i/LMP7 in maintenance of protein homeostasis under cytokine induced oxidative stress.
Hewing, B., Ludwig, A., Dan, C., Poetzsch, M., Hannemann, C., Petry, A., Lauer, D., Görlach, A., Kaschina, E., Müller, D.N., Baumann, G., Stangl, V., Stangl, K., Wilck, N.   +13 more
openaire   +3 more sources

Correction to "Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema via Activating NRF1/2-P62 Axis and Suppressing IRF4 Transcription". [PDF]

Adv Sci (Weinh)
Advanced Science, Volume 13, Issue 11, 23 February 2026.
europepmc   +2 more sources

Genetic variability in LMP2 and LMP7 is associated with the risk of esophageal squamous cell carcinoma in the Kazakh population but is not associated with HPV infection. [PDF]

PLoS ONE, 2017
The Kazakh population in Xinjiang Province in northwestern China exhibits a high incidence of esophageal squamous cell carcinoma (ESCC). Although the etiology of esophageal carcinoma (EC) has not been elucidated, there are reports of the involvement of ...
Lan Yang, Yu Ji, Ling Chen, Mei Li, Fei Wu, Jianming Hu, Jinfang Jiang, Xiaobin Cui, Yunzhao Chen, Lijuan Pang, Yutao Wei, Feng Li   +11 more
doaj   +1 more source

LMP2 and LMP7 gene polymorphism in Mexican populations: Mestizos and Amerindians [PDF]

Genes & Immunity, 2002
Low molecular weight polypeptide (LMP) genes are located within the major histocompatibility complex and have been associated with autoimmune diseases such as ankylosing spondylitis. In order to define the distribution of LMP genes in Mexican populations, the LMP2 and LMP7 polymorphism was analyzed in 312 Mexican individuals (95 Mexican Mestizos, 48 ...
G, Vargas-Alarcón, R, Gamboa, Y, Vergara, J M, Rodriguez-Zepeda, A, de la Peña, R, Izaguirre, J, Zuñiga, J A, Ruiz-Morales, J, Granados   +8 more
openaire   +2 more sources

Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. [PDF]

PLoS ONE, 2016
Immunoproteasomes, harboring the active site subunits β5i/LMP7, β1i/LMP2, and β2i/MECL1 exert protective, regulatory or modulating functions during infection-induced immune responses.
Felicia Kirschner, Katrin Reppe, Nadine Andresen, Martin Witzenrath, Frédéric Ebstein, Peter-Michael Kloetzel   +5 more
doaj   +1 more source