Results 11 to 20 of about 2,423 (198)

Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice. [PDF]

PLoS ONE, 2013
General cellular functions of proteasomes occur through protein degradation, whereas the specific function of immunoproteasomes is the optimization of antigen processing associated with MHC class I.
Xuefeng Duan, Takashi Imai, Bin Chou, Liping Tu, Kunisuke Himeno, Kazutomo Suzue, Makoto Hirai, Tomoyo Taniguchi, Hiroko Okada, Chikako Shimokawa, Hajime Hisaeda   +10 more
doaj   +5 more sources

Immunoproteasome subunit ß5i/LMP7-deficiency in atherosclerosis [PDF]

Scientific Reports, 2017
Management of protein homeostasis by the ubiquitin-proteasome system is critical for atherosclerosis development. Recent studies showed controversial results on the role of immunoproteasome (IP) subunit β5i/LMP7 in maintenance of protein homeostasis ...
Verena Stangl, Baumann, G., Poetzsch, M., Müller, D.N., Stangl, V., Karl Stangl, Baumann, Gert, Bernd Hewing, Kaschina, E., Gert Baumann, Kaschina, Elena, Hannemann, C., Wilck, N., Stangl, K., Antje Ludwig, Petry, A., Andreas Petry, Hewing, Bernd, Lauer, Dilyara, Ludwig, Antje, Lauer, D., Görlach, Agnes, Stangl, Karl, Carmen Hannemann, Dan, C., Cristian Dan, Ludwig, A., Agnes Görlach, Elena Kaschina, Pötzsch, Max, Nicola Wilck, Görlach, A., Dilyara Lauer, Müller, Dominik N., Petry, Andreas, Hannemann, Carmen, Stangl, Verena, Dominik N. Müller, Max Pötzsch, Wilck, Nicola, Hewing, B.   +40 more
core   +4 more sources

Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity [PDF]

The EMBO Reports, 2018
Cells of hematopoietic origin express high levels of the immunoproteasome, a cytokine-inducible proteasome variant comprising the proteolytic subunits LMP2 (β1i), MECL-1 (β2i), and LMP7 (β5i).
LaStant, Jacob J., Owens, Timothy D., Jacob J LaStant, J Michael Bradshaw, Herman S Overkleeft, Christopher Tsu, Michael Basler, Claire L Langrish, Bradshaw, J. Michael, Elmer Maurits, Schmidt, Christian, Maurits, Elmer, Overkleeft, Herman S., Christian Schmidt, Tsu, Christopher, Lindstrom, Michelle M., Michelle M Lindstrom, Timothy D Owens, Marcus Groettrup, Basler, Michael, Christopher J Kirk, Lindstrom MM, Basler, M., Schmidt C, Bradshaw JM, Maurits, E., Tsu C, Groettrup, M., LaStant, J.J., Overkleeft HS, Kirk, C.J., Groettrup, Marcus, Langrish CL, Groettrup M, Schmidt, C., Overkleeft, H.S., Kirk CJ, Owens TD, LaStant JJ, Tsu, C., Owens, T.D., Langrish, C.L., Basler M, Maurits E, Lindstrom, M.M., Bradshaw, J.M.   +45 more
core   +7 more sources

The proteasome system in infection: impact of β5 and LMP7 on composition, maturation and quantity of active proteasome complexes. [PDF]

PLoS ONE, 2012
Proteasomes are the major enzyme complexes for non-lysosomal protein degradation in eukaryotic cells. Mammals express two sets of catalytic subunits: the constitutive subunits β1, β2 and β5 and the immunosubunits LMP2 (β1i), MECL-1 (β2i) and LMP7 (β5i ...
Thorsten Joeris, Nicole Schmidt, David Ermert, Petra Krienke, Alexander Visekruna, Ulrike Kuckelkorn, Stefan H E Kaufmann, Ulrich Steinhoff   +7 more
doaj   +3 more sources

Genetic variability in LMP2 and LMP7 is associated with the risk of esophageal squamous cell carcinoma in the Kazakh population but is not associated with HPV infection. [PDF]

PLoS ONE, 2017
The Kazakh population in Xinjiang Province in northwestern China exhibits a high incidence of esophageal squamous cell carcinoma (ESCC). Although the etiology of esophageal carcinoma (EC) has not been elucidated, there are reports of the involvement of ...
Lan Yang, Yu Ji, Ling Chen, Mei Li, Fei Wu, Jianming Hu, Jinfang Jiang, Xiaobin Cui, Yunzhao Chen, Lijuan Pang, Yutao Wei, Feng Li   +11 more
doaj   +2 more sources

Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia [PDF]

Frontiers in Immunology, 2021
The immunoproteasome, a special isoform of the 20S proteasome, is expressed when the cells receive an inflammatory signal. Immunoproteasome inhibition proved efficacy in the treatment of autoimmune diseases.
Sheng-hong Du, Sheng-hong Du, Yu-jiao Xiang, Lu Liu, Mu Nie, Mu Nie, Yu Hou, Ling Wang, Ban-ban Li, Ban-ban Li, Miao Xu, Qing-liang Teng, Jun Peng, Jun Peng, Ming Hou, Ming Hou, Ming Hou, Ming Hou, Yan Shi   +18 more
doaj   +3 more sources

Reduced Expression of the Antigen Processing Machinery Components TAP2, LMP2, and LMP7 in Tonsillar and Base of Tongue Cancer and Implications for Clinical Outcome

Translational Oncology, 2015
OBJECTIVES: Patients with human papillomavirus (HPV)–positive tonsillar squamous cell carcinoma (TSCC) and base of tongue squamous cell carcinoma (BOTSCC) have a better clinical outcome than those with corresponding HPV-negative tumors.
Nikolaos Tertipis, Linnea Haeggblom, Nathalie Grün, Cecilia Nordfors, Anders Näsman, Tina Dalianis, Torbjörn Ramqvist   +6 more
doaj   +2 more sources

Ageing-related changes in the levels of β-catenin, CacyBP/SIP, galectin-3 and immunoproteasome subunit LMP7 in the heart of men.

PLoS ONE, 2020
Aging is a major risk factor for morbidity and mortality from cardiovascular causes in men. To better understand the cellular processes related to age-related cardiac complications, we undertook research aimed at comparative evaluation of genes ...
Irena Kasacka, Żaneta Piotrowska, Michał Niezgoda, Alicja Lewandowska, Wojciech Łebkowski   +4 more
doaj   +2 more sources

Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7 [PDF]

Oncotarget, 2017
Chronic inflammation is a well-known risk factor in development of intestinal tumorigenesis, although the exact mechanisms underlying development of colitis-associated cancer (CAC) still remain obscure.
Hartmann, Sabrina, Pantazis, Georgios, Visekruna, Alexander, Vachharajani, Niyati, Luu, Maik, Pautz, Sabine, Jenike, Elena, Steinhoff, Ulrich, Joeris, Thorsten, Prinz, Immo, Hofer, Markus J   +10 more
core   +4 more sources

Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis

Cardiovascular Research, 2022
AimsThe loss of vascular wall cells in allotransplanted arteries is the initial event leading to transplant arteriosclerosis (TA) and ensuing loss of allograft function. Pharmacological agents able to prevent TA are currently lacking.
Song, Yanping, Yanping Song, Hu, Shaobo, Liu, Nan, Peng Xian, Michael Basler, Johnson, Henry W. B., Xian, Peng, Henry W B Johnson, Yuan Li, Li, Jun, Li, Yuan, Kirk, Christopher J., Jun Li, Shaobo Hu, Nan Liu, Marcus Groettrup, Groettrup, Marcus, Basler, Michael, Christopher J Kirk   +19 more
core   +3 more sources