Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice. [PDF]
PLoS ONE, 2013 General cellular functions of proteasomes occur through protein degradation, whereas the specific function of immunoproteasomes is the optimization of antigen processing associated with MHC class I.
Xuefeng Duan +10 more
doaj +5 more sources
Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV‐induced meningitis [PDF]
European Journal of Immunology, 2015 In addition to antigen processing, immunoproteasomes were recently shown to exert functions influencing cytokine production by monocytes and T cells, T‐helper cell differentiation, and T‐cell survival. Moreover, selective inhibition of the immunoproteasome subunit LMP7 ameliorated symptoms of autoimmune diseases including CD4+ T‐cell mediated EAE.
Mundt Sarah +4 more
core +7 more sources
Immunoproteasome subunit ß5i/LMP7-deficiency in atherosclerosis [PDF]
Scientific Reports, 2017 AbstractManagement of protein homeostasis by the ubiquitin-proteasome system is critical for atherosclerosis development. Recent studies showed controversial results on the role of immunoproteasome (IP) subunit β5i/LMP7 in maintenance of protein homeostasis under cytokine induced oxidative stress.
Hewing, B. +13 more
openaire +4 more sources
Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity [PDF]
The EMBO Reports, 2018 Cells of hematopoietic origin express high levels of the immunoproteasome, a cytokine-inducible proteasome variant comprising the proteolytic subunits LMP2 (β1i), MECL-1 (β2i), and LMP7 (β5i). Targeting the immunoproteasome in pre-clinical models of autoimmune diseases with the epoxyketone inhibitor ONX 0914 has proven to be effective.
Michael Basler +11 more
core +7 more sources
Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection
Scientific Reports, 2022 Immunoproteasomes (IP) serve as an important modulator of immune responses to pathogens and other pathological factors. LMP7/β5i, one of the IP subunits, plays a critical role in autoimmune diseases by downregulating inflammation.
Kris Genelyn Dimasuay +7 more
doaj +3 more sources
Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7 [PDF]
Oncotarget, 2017 Chronic inflammation is a well-known risk factor in development of intestinal tumorigenesis, although the exact mechanisms underlying development of colitis-associated cancer (CAC) still remain obscure. The activity and function of immunoproteasome has been extensively analyzed in the context of inflammation and infectious diseases.
Vachharajani, Niyati +10 more
openaire +4 more sources
Genetic variability in LMP2 and LMP7 is associated with the risk of esophageal squamous cell carcinoma in the Kazakh population but is not associated with HPV infection. [PDF]
PLoS ONE, 2017 The Kazakh population in Xinjiang Province in northwestern China exhibits a high incidence of esophageal squamous cell carcinoma (ESCC). Although the etiology of esophageal carcinoma (EC) has not been elucidated, there are reports of the involvement of ...
Lan Yang +11 more
doaj +2 more sources
The proteasome system in infection: impact of β5 and LMP7 on composition, maturation and quantity of active proteasome complexes. [PDF]
PLoS ONE, 2012 Proteasomes are the major enzyme complexes for non-lysosomal protein degradation in eukaryotic cells. Mammals express two sets of catalytic subunits: the constitutive subunits β1, β2 and β5 and the immunosubunits LMP2 (β1i), MECL-1 (β2i) and LMP7 (β5i ...
Thorsten Joeris +7 more
doaj +3 more sources
Reduced Expression of the Antigen Processing Machinery Components TAP2, LMP2, and LMP7 in Tonsillar and Base of Tongue Cancer and Implications for Clinical Outcome [PDF]
Translational Oncology, 2015 OBJECTIVES: Patients with human papillomavirus (HPV)–positive tonsillar squamous cell carcinoma (TSCC) and base of tongue squamous cell carcinoma (BOTSCC) have a better clinical outcome than those with corresponding HPV-negative tumors.
Nikolaos Tertipis +6 more
doaj +2 more sources
Cardiovascular Research, 2022 Abstract Aims The loss of vascular wall cells in allotransplanted arteries is the initial event leading to transplant arteriosclerosis (TA) and ensuing loss of allograft function. Pharmacological agents able to prevent TA are currently lacking.
Jun Li +9 more
openaire +3 more sources