Results 21 to 30 of about 8,916 (246)

Regulation of Immunoproteasome Function in the Lung [PDF]

Scientific Reports, 2015
AbstractImpaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to impaired immune responses. Elimination of infected cells is achieved by cytotoxic CD8+  T cells that are activated by MHC I-mediated presentation of pathogen-derived ...
Ilona E. Keller, Oliver Vosyka, Shinji Takenaka, Alexander Kloß, Burkhardt Dahlmann, Lianne I. Willems, Martijn Verdoes, Herman S. Overkleeft, Élisabeth Marcos, Serge Adnot, Stefanie M. Hauck, Clemens Ruppert, Andreas Günther, Susanne Herold, Shinji Ohno, Heiko Adler, Oliver Eickelberg, Silke Meiners   +17 more
openalex   +8 more sources

Recent Advances in the Development of Immunoproteasome Inhibitors as Anti-Cancer Agents: The Past 5 Years [PDF]

Molecules
The immunoproteasome (iCP) is an isoform of the 20S proteasome that is expressed in response to cellular stress or inflammatory stimuli. The primary role of the iCP is to hydrolyze proteins into peptides that can be loaded into the MHC-I complex.
Francesca Mancuso, Carla Di Chio, Francesca Di Matteo, Gerardina Smaldone, Nunzio Iraci, Salvatore Vincenzo Giofrè   +5 more
doaj   +2 more sources

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis [PDF]

Cell
Manuela Moritz, Mark Walkenhorst, Vanessa Vieira   +2 more
exaly   +2 more sources

Association of immunoproteasomes with the endoplasmic reticulum [PDF]

Biochemical Journal, 2000
Proteasomes are complex multisubunit proteases which play a critical role in intracellular proteolysis. Immunoproteasomes, which contain three γ-interferon-inducible subunits, are a subset of proteasomes which have a specialized function in antigen processing for presentation by the MHC class I pathway.
Paul Brooks, Rachael Z. Murray, Grant Mason, Klavs B. Hendil, A. Jennifer Rivett   +4 more
openalex   +5 more sources

CGRPβ suppresses the pathogenesis of ulcerative colitis via the immunoproteasome [PDF]

Scientific Reports
Various factors have been implicated in the pathogenesis of ulcerative colitis (UC), with immune system failure being the most important one. Calcitonin gene-related peptide (CGRP), a neuropeptide with two isoforms, CGRPα and CGRPβ, has been reported to ...
Tatsuya Shibao, Hiroaki Hase, Kodai Mizokami, Atsushi Usui, Kaori Kitae, Yuko Ueda, Kentaro Jingushi, Kazutake Tsujikawa   +7 more
doaj   +2 more sources

The Function of Immunoproteasomes—An Immunologists’ Perspective [PDF]

Cells, 2021
Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a specialized form of proteasomes, known as immunoproteasomes, in which the constitutive catalytic sites are replaced for cytokine-inducible homologues.
Bart L. van den Eshof, Lobna Medfai, Emanuele Nolfi, Magdalena Wawrzyniuk, Alice J. A. M. Sijts   +4 more
openaire   +5 more sources

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome. [PDF]

Adv Sci (Weinh)
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Demel UM, Meurer A, Zaghla BKQ, Atay B, Steiert D, Hummel LV, Isaakidis K, Zang C, Korenkov M, Schielin M, Yousefian S, Mecklenbräuker S, Kirchner M, Haas S, Busse A, Mertins P, Müller S, Wirth M, Klatt MG, Keller U.   +19 more
europepmc   +2 more sources

Ubiquitin-conjugating enzyme UBE2N modulates proteostasis in immunoproteasome-positive acute myeloid leukemia. [PDF]

J Clin Invest
Ishikawa C, Barreyro L, Sampson AM, Hueneman KM, Choi K, Philbrook SY, Choi I, Bolanos LC, Wunderlich M, Volk AG, Watowich SS, Greis KD, Starczynowski DT.   +12 more
europepmc   +2 more sources

Immunoproteasome inhibition and bioactivity of thiasyrbactins [PDF]

Bioorganic & Medicinal Chemistry, 2017
A family of macrodilactam natural products, the syrbactins, are known proteasome inhibitors. A small group of syrbactin analogs was prepared with a sulfur-for-carbon substitution to enhance synthetic accessibility and facilitate modulation of their solubility.
Nicole A. Bakas, Chad R. Schultz, Lisette Yco, Christopher Roberts, Chia-en A. Chang, André S. Bachmann, Michael C. Pirrung   +6 more
openalex   +5 more sources

Immunoproteasome remodeling in senescing human macrophages reveals the loss of PA28αβ capping as a hallmark of immunosenescence. [PDF]

Commun Biol
Monittola F, Masini S, Montanari M, Nasoni MG, Bianchi M, De Matteis R, Ricci A, Ligi D, Luchetti F, Canonico B, Magnani M, Menotta M, Fraternale A, Crinelli R.   +13 more
europepmc   +3 more sources