Results 21 to 30 of about 5,747 (197)
The Immunoproteasome: An Emerging Therapeutic Target
Current Topics in Medicinal Chemistry, 2011 The proteasome, a large multisubunit protease complex, has been extensively investigated over the years, greatly enhancing our understanding of critical roles that the proteasome plays in cells.
Lee, Wooin +3 more
core +3 more sources
Computational analysis and modeling of cleavage by the immunoproteasome and the constitutive proteasome [PDF]
BMC Bioinformatics, 2010 Background Proteasomes play a central role in the major histocompatibility class I (MHCI) antigen processing pathway. They conduct the proteolytic degradation of proteins in the cytosol, generating the C-terminus of CD8 T cell epitopes and MHCI-peptide ...
Lafuente Esther M +2 more
doaj +2 more sources
Journal of Translational MedicineBackground How to select muscle-invasive bladder cancer (MIBC) patients who are sensitive to immunotherapy is an unmet medical need. This study aimed to explore the role of immunoproteasome subunits as a novel signature for predicting efficacy of ...
XinJian Wang +10 more
doaj +2 more sources
New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells [PDF]
Journal of Immunology Research, 2015 The immunoproteasome is a highly efficient proteolytic machinery derived from the constitutive proteasome and is abundantly expressed in immune cells.
Hiroaki Kimura +3 more
doaj +2 more sources
Targeting immunoproteasome in neurodegeneration: a glance to the future
Pharmacology & Therapeutics, 2023 The immunoproteasome is a specialized form of proteasome equipped with modified catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen processing and immune system modulation.
Graziani G. +11 more
core +4 more sources
The Functional and Mechanistic Roles of Immunoproteasome Subunits in Cancer
Cells, 2021 Cell-mediated immunity is driven by antigenic peptide presentation on major histocompatibility complex (MHC) molecules. Specialized proteasome complexes called immunoproteasomes process viral, bacterial, and tumor antigens for presentation on MHC class I
Satyendra Chandra Tripathi +2 more
doaj +2 more sources
Astrocytic LMP2 Coordinates NF-κB and TGF-β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion. [PDF]
Adv Sci (Weinh)ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Mao Y +7 more
europepmc +2 more sources
Type I and II Interferon Signalling Characterizes the Transcriptional Landscape of Sweet Syndrome. [PDF]
Exp DermatolABSTRACT Sweet syndrome (SS) is an autoinflammatory neutrophilic dermatosis characterized by abrupt‐onset inflammatory skin lesions and systemic symptoms, yet its molecular pathogenesis remains incompletely defined. To delineate disease‐specific inflammatory programmes, we performed NanoString‐based transcriptomic analysis of SS skin lesions and ...
Calabrese L +12 more
europepmc +2 more sources
The Function of Immunoproteasomes—An Immunologists’ Perspective [PDF]
Cells, 2021 Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a specialized form of proteasomes, known as immunoproteasomes, in which the constitutive catalytic sites are replaced for cytokine-inducible homologues.
Bart L. van den Eshof +4 more
openaire +5 more sources
Cell Death and Disease, 2022 Muscle repair in dysferlinopathies is defective. Although macrophage (Mø)-rich infiltrates are prominent in damaged skeletal muscles of patients with dysferlinopathy, the contribution of the immune system to the disease pathology remains to be fully ...
A. Farini +8 more
doaj +1 more source