Results 21 to 30 of about 5,882 (203)

Immunoproteasome subunits are novel signatures for predicting efficacy of immunotherapy in muscle invasive bladder cancer

Journal of Translational Medicine
Background How to select muscle-invasive bladder cancer (MIBC) patients who are sensitive to immunotherapy is an unmet medical need. This study aimed to explore the role of immunoproteasome subunits as a novel signature for predicting efficacy of ...
XinJian Wang, Hang You, Teng Zhang, Yuan Li, XinYu Chen, Michael Basler, QingMing Jiang, Han Chen, Nan Liu, Fang Yuan, Jun Li   +10 more
doaj   +2 more sources

Computational analysis and modeling of cleavage by the immunoproteasome and the constitutive proteasome [PDF]

BMC Bioinformatics, 2010
Background Proteasomes play a central role in the major histocompatibility class I (MHCI) antigen processing pathway. They conduct the proteolytic degradation of proteins in the cytosol, generating the C-terminus of CD8 T cell epitopes and MHCI-peptide ...
Lafuente Esther M, Diez-Rivero Carmen M, Reche Pedro A   +2 more
doaj   +2 more sources

ONX 0914 Lacks Selectivity for the Cardiac Immunoproteasome in CoxsackievirusB3 Myocarditis of NMRI Mice and Promotes Virus-Mediated Tissue Damage [PDF]

Cells, 2020
Inhibition of proteasome function by small molecules is highly efficacious in cancer treatment. Other than non-selective proteasome inhibitors, immunoproteasome-specific inhibitors allow for specific targeting of the proteasome in immune cells and the ...
Hannah Louise Neumaier, Shelly Harel, Karin Klingel, Ziya Kaya, Arnd Heuser, Meike Kespohl, Antje Beling   +6 more
doaj   +2 more sources

A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus. [PDF]

PLoS ONE, 2011
Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates and immunocompromised adults.
Sarah Hutchinson, Stuart Sims, Geraldine O'Hara, Jon Silk, Uzi Gileadi, Vincenzo Cerundolo, Paul Klenerman   +6 more
doaj   +2 more sources

Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation

Journal of Neuroinflammation
Objective Obesity represents a significant global health challenge characterized by chronic low-grade inflammation and metabolic dysregulation. The hypothalamus, a key regulator of energy homeostasis, is particularly susceptible to obesity’s deleterious ...
Nicolás Albornoz, Javiera Álvarez-Indo, Adely de la Peña, Eloisa Arias-Muñoz, Alanis Coca, Fabián Segovia-Miranda, Bredford Kerr, Mauricio Budini, Alfredo Criollo, María A. García-Robles, Eugenia Morselli, Andrea Soza, Patricia V. Burgos   +12 more
doaj   +2 more sources

Astrocytic LMP2 Coordinates NF-κB and TGF-β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion. [PDF]

Adv Sci (Weinh)
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Mao Y, Ma R, Lin Z, Zhao H, Liu Y, Su Y, Zhang X, Chen X.   +7 more
europepmc   +2 more sources

The Function of Immunoproteasomes—An Immunologists’ Perspective [PDF]

Cells, 2021
Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a specialized form of proteasomes, known as immunoproteasomes, in which the constitutive catalytic sites are replaced for cytokine-inducible homologues.
Bart L. van den Eshof, Lobna Medfai, Emanuele Nolfi, Magdalena Wawrzyniuk, Alice J. A. M. Sijts   +4 more
openaire   +5 more sources

Immunoproteasome Function in Normal and Malignant Hematopoiesis [PDF]

, 2021
The ubiquitin–proteasome system (UPS) is a central part of protein homeostasis, degrading not only misfolded or oxidized proteins but also proteins with essential functions. The fact that a healthy hematopoietic system relies on the regulation of protein
Elke Krüger, Heidel, Florian H., Ebstein, Frédéric, Nuria Tubío-Santamaría, Krüger, Elke, Florian H. Heidel, Tubío-Santamaría, Nuria, Frédéric Ebstein   +7 more
core   +1 more source

Suppression of prostate cancer and amelioration of the immunosuppressive tumor microenvironment through selective immunoproteasome inhibition

OncoImmunology, 2023
New treatment options to battle hormone-refractory prostate carcinoma (PC) are a pressing medical need. Chronic inflammation has been implicated in PC etiology.
Julia Koerner, Dennis Horvath, Franziska Oliveri, Jun Li, Michael Basler   +4 more
doaj   +1 more source

Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia

Frontiers in Immunology, 2021
The immunoproteasome, a special isoform of the 20S proteasome, is expressed when the cells receive an inflammatory signal. Immunoproteasome inhibition proved efficacy in the treatment of autoimmune diseases.
Sheng-hong Du, Sheng-hong Du, Yu-jiao Xiang, Lu Liu, Mu Nie, Mu Nie, Yu Hou, Ling Wang, Ban-ban Li, Ban-ban Li, Miao Xu, Qing-liang Teng, Jun Peng, Jun Peng, Ming Hou, Ming Hou, Ming Hou, Ming Hou, Yan Shi   +18 more
doaj   +1 more source