Results 11 to 20 of about 5,882 (203)
The role of the immunoproteasome in cardiovascular disease
Pharmacological ResearchThe ubiquitinproteasome system (UPS) is the main mechanism responsible for the intracellular degradation of misfolded or damaged proteins. Under inflammatory conditions, the immunoproteasome, an isoform of the proteasome, can be induced, enhancing the ...
Yifei Nie +6 more
doaj +4 more sources
Regulation of Immunoproteasome Function in the Lung [PDF]
Scientific Reports, 2015 AbstractImpaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to impaired immune responses. Elimination of infected cells is achieved by cytotoxic CD8+ T cells that are activated by MHC I-mediated presentation of pathogen-derived ...
Keller, I.E. +17 more
openaire +9 more sources
Immunoproteasome inhibition attenuates experimental psoriasis
Frontiers in Immunology, 2022 IntroductionPsoriasis is an autoimmune skin disease associated with multiple comorbidities. The immunoproteasome is a special form of the proteasome expressed in cells of hematopoietic origin.MethodsThe therapeutic use of ONX 0914, a selective inhibitor ...
Marta del Rio Oliva +4 more
doaj +2 more sources
Immunoproteasome inhibition and bioactivity of thiasyrbactins [PDF]
Bioorganic & Medicinal Chemistry, 2018 A family of macrodilactam natural products, the syrbactins, are known proteasome inhibitors. A small group of syrbactin analogs was prepared with a sulfur-for-carbon substitution to enhance synthetic accessibility and facilitate modulation of their solubility.
Bakas, Nicole A +6 more
openaire +6 more sources
Corneal wound healing is compromised by immunoproteasome deficiency. [PDF]
PLoS ONE, 2013 Recent studies have revealed roles for immunoproteasome in regulating cell processes essential for maintaining homeostasis and in responding to stress and injury.
Deborah A Ferrington +10 more
doaj +2 more sources
On the role of the immunoproteasome in transplant rejection [PDF]
Immunogenetics, 2018 The immunoproteasome is expressed in cells of hematopoietic origin and is induced during inflammation by IFN-γ. Targeting the immunoproteasome with selective inhibitors has been shown to be therapeutically effective in pre-clinical models for autoimmune diseases, colitis-associated cancer formation, and transplantation.
Michael Basler, Jun Li, Marcus Groettrup
openaire +4 more sources
On the Role of the Immunoproteasome in Protein Homeostasis [PDF]
Cells, 2021 Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
doaj +4 more sources
The Immunoproteasome: An Emerging Therapeutic Target
Current Topics in Medicinal Chemistry, 2011 The proteasome, a large multisubunit protease complex, has been extensively investigated over the years, greatly enhancing our understanding of critical roles that the proteasome plays in cells. The FDA approval of bortezomib for the treatment of multiple myeloma and mantle cell lymphoma has validated the proteasome as an anticancer target.
Wooin, Lee, Kyung Bo, Kim
openaire +3 more sources
New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells [PDF]
Journal of Immunology Research, 2015 The immunoproteasome is a highly efficient proteolytic machinery derived from the constitutive proteasome and is abundantly expressed in immune cells.
Hiroaki Kimura +3 more
doaj +2 more sources
Immunoproteasome deficiency modifies the alternative pathway of NFκB signaling. [PDF]
PLoS ONE, 2013 Immunoproteasome is a protease abundant in immune cells and also present, albeit at lower concentrations, in cells outside the immune system. Recent evidence supports a novel role for the immunoproteasome in the cellular stress response potentially ...
Marcela Maldonado +6 more
doaj +2 more sources