Results 11 to 20 of about 5,747 (197)

On the Role of the Immunoproteasome in Protein Homeostasis [PDF]

Cells, 2021
Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
doaj   +5 more sources

The role of the immunoproteasome in cardiovascular disease

Pharmacological Research
The ubiquitinproteasome system (UPS) is the main mechanism responsible for the intracellular degradation of misfolded or damaged proteins. Under inflammatory conditions, the immunoproteasome, an isoform of the proteasome, can be induced, enhancing the ...
Yifei Nie, Zhao Ma, Baoen Zhang, Meichen Sun, Dongfeng Zhang, Hui-Hua Li, Xiantao Song   +6 more
doaj   +4 more sources

Immunoproteasome inhibition attenuates experimental psoriasis

Frontiers in Immunology, 2022
IntroductionPsoriasis is an autoimmune skin disease associated with multiple comorbidities. The immunoproteasome is a special form of the proteasome expressed in cells of hematopoietic origin.MethodsThe therapeutic use of ONX 0914, a selective inhibitor ...
Marta del Rio Oliva, Mark Mellett, Mark Mellett, Michael Basler, Michael Basler   +4 more
doaj   +2 more sources

Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. [PDF]

PLoS ONE, 2016
The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome.
Haiming M Liu, Deborah A Ferrington, Cory W Baumann, LaDora V Thompson   +3 more
doaj   +3 more sources

Immunoproteasome inhibition and bioactivity of thiasyrbactins [PDF]

Bioorganic & Medicinal Chemistry, 2018
A family of macrodilactam natural products, the syrbactins, are known proteasome inhibitors. A small group of syrbactin analogs was prepared with a sulfur-for-carbon substitution to enhance synthetic accessibility and facilitate modulation of their ...
André S. Bachmann, Pirrung, Michael C, Schultz, Chad R, Bachmann, André S, Chia-en A. Chang, Chad R. Schultz, Lisette P. Yco, Bakas, Nicole A, Nicole A. Bakas, Michael C. Pirrung, Yco, Lisette P, Roberts, Christopher C, Christopher C. Roberts, Chang, Chia-En A   +13 more
core   +6 more sources

Regulation of immunoproteasome function in the lung [PDF]

Scientific Reports, 2015
Contains fulltext : 152662.pdf (Publisher’s version ) (Open Access)Impaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD).
Meiners, Silke, Ohno, S., Meiners, S., Kloss, Alexander, Eickelberg, O., Overkleeft, Hermen S., Ruppert, Clemens, Dahlmann, Burkhardt, Dahlmann, B., Willems, L.I., Adnot, Serge, Vosyka, O., Hauck, Stefanie M., Keller, I.E., Keller, Ilona E., Willems, Lianne I., Eickelberg, Oliver, Marcos, E., Overkleeft, H.S., Verdoes, M., Herold, S., Adler, Heiko, Vosyka, Oliver, Gunther, A., Verdoes, Martijn, Guenther, A., Kloss, A., Hauck, S.M., Guenther, Andreas, Takenaka, Shinji, Herold, Susanne, Ruppert, C., Marcos, Elisabeth, Ohno, Shinji, Adnot, S., Adler, H., Takenaka, S.   +36 more
core   +10 more sources

Corneal wound healing is compromised by immunoproteasome deficiency. [PDF]

PLoS ONE, 2013
Recent studies have revealed roles for immunoproteasome in regulating cell processes essential for maintaining homeostasis and in responding to stress and injury.
Deborah A Ferrington, Heidi Roehrich, Angela A Chang, Craig W Huang, Marcela Maldonado, Wendy Bratten, Abrar A Rageh, Neal D Heuss, Dale S Gregerson, Elizabeth F Nelson, Ching Yuan   +10 more
doaj   +2 more sources

On the role of the immunoproteasome in transplant rejection [PDF]

Immunogenetics, 2019
The immunoproteasome is expressed in cells of hematopoietic origin and is induced during inflammation by IFN-γ. Targeting the immunoproteasome with selective inhibitors has been shown to be therapeutically effective in pre-clinical models for autoimmune ...
Li, Jun, Gröttrup, Marcus, Basler, Michael   +2 more
core   +4 more sources

Immunoproteasome deficiency modifies the alternative pathway of NFκB signaling. [PDF]

PLoS ONE, 2013
Immunoproteasome is a protease abundant in immune cells and also present, albeit at lower concentrations, in cells outside the immune system. Recent evidence supports a novel role for the immunoproteasome in the cellular stress response potentially ...
Marcela Maldonado, Rebecca J Kapphahn, Marcia R Terluk, Neal D Heuss, Ching Yuan, Dale S Gregerson, Deborah A Ferrington   +6 more
doaj   +2 more sources

Discovery and Early Clinical Development of Selective Immunoproteasome Inhibitors

Cells, 2021
Inhibitors of the proteolytic activity of the 20S proteasome have transformed the treatment of multiple B-cell malignancies. These agents have also been employed with success in the treatment of patients with autoimmune diseases and immune-mediated ...
Christopher J. Kirk, Tony Muchamuel, Jinhai Wang, R. Andrea Fan   +3 more
doaj   +2 more sources