Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors [PDF]
Cells, 2022 Targeting proteasome with proteasome inhibitors (PIs) is an approved treatment strategy in multiple myeloma that has also been explored pre-clinically and clinically in other hematological malignancies.
Andrej Besse +6 more
doaj +4 more sources
On the Role of the Immunoproteasome in Protein Homeostasis [PDF]
Cells, 2021 Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
doaj +4 more sources
Immunoproteasome Inhibition Impairs Differentiation but Not Survival of T Helper 17 Cells [PDF]
CellsAutoimmune and inflammatory diseases are characterized by aberrant immune responses. The immunoproteasome was proposed as a target for such Th cell-mediated diseases due to its role in the activation, differentiation and function of T cells.
Franziska Oliveri +3 more
doaj +2 more sources
Computational analysis and modeling of cleavage by the immunoproteasome and the constitutive proteasome [PDF]
BMC Bioinformatics, 2010 Background Proteasomes play a central role in the major histocompatibility class I (MHCI) antigen processing pathway. They conduct the proteolytic degradation of proteins in the cytosol, generating the C-terminus of CD8 T cell epitopes and MHCI-peptide ...
Lafuente Esther M +2 more
doaj +7 more sources
Immunoproteasome subunits are novel signatures for predicting efficacy of immunotherapy in muscle invasive bladder cancer [PDF]
Journal of Translational MedicineBackground How to select muscle-invasive bladder cancer (MIBC) patients who are sensitive to immunotherapy is an unmet medical need. This study aimed to explore the role of immunoproteasome subunits as a novel signature for predicting efficacy of ...
XinJian Wang +10 more
doaj +2 more sources
PDGF-D-induced immunoproteasome activation and cell-cell interactions [PDF]
Computational and Structural Biotechnology Journal, 2023 Platelet-derived growth factor-D (PDGF-D) is abundantly expressed in ocular diseases. Yet, it remains unknown whether and how PDGF-D affects ocular cells or cell-cell interactions in the eye.
Jianing Zhang +9 more
doaj +2 more sources
Immunoproteasome inhibition attenuates experimental psoriasis
Frontiers in Immunology, 2022 IntroductionPsoriasis is an autoimmune skin disease associated with multiple comorbidities. The immunoproteasome is a special form of the proteasome expressed in cells of hematopoietic origin.MethodsThe therapeutic use of ONX 0914, a selective inhibitor ...
Marta del Rio Oliva +4 more
doaj +4 more sources
Non-covalent immunoproteasome inhibitors induce cell cycle arrest in multiple myeloma MM.1R cells [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Proteasome inhibition is a promising strategy for the treatment of multiple myeloma; unfortunately, this disease is often associated with an increasing chemoresistance.
Roberta Ettari +9 more
doaj +2 more sources
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis
EMBO Molecular Medicine, 2014 Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function
Michael Basler +2 more
exaly +2 more sources
The role of the immunoproteasome in cardiovascular disease
Pharmacological ResearchThe ubiquitinî—¸proteasome system (UPS) is the main mechanism responsible for the intracellular degradation of misfolded or damaged proteins. Under inflammatory conditions, the immunoproteasome, an isoform of the proteasome, can be induced, enhancing the ...
Yifei Nie +6 more
doaj +3 more sources