Results 11 to 20 of about 4,164 (128)
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis
EMBO Molecular Medicine, 2014 Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function
Michael Basler +2 more
exaly +2 more sources
Cells, 2022 Targeting proteasome with proteasome inhibitors (PIs) is an approved treatment strategy in multiple myeloma that has also been explored pre-clinically and clinically in other hematological malignancies.
Andrej Besse +6 more
doaj +1 more source
Immunoproteasome deficiency protects in the retina after optic nerve crush. [PDF]
PLoS ONE, 2015 The immunoproteasome is upregulated by disease, oxidative stress, and inflammatory cytokines, suggesting an expanded role for the immunoproteasome in stress signaling that goes beyond its canonical role in generating peptides for antigen presentation ...
Nathan J Schuld +9 more
doaj +1 more source
Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. [PDF]
PLoS ONE, 2016 The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome.
Haiming M Liu +3 more
doaj +1 more source
Cell Death and Disease, 2022 Muscle repair in dysferlinopathies is defective. Although macrophage (Mø)-rich infiltrates are prominent in damaged skeletal muscles of patients with dysferlinopathy, the contribution of the immune system to the disease pathology remains to be fully ...
A. Farini +8 more
doaj +1 more source
OncoImmunology, 2023 New treatment options to battle hormone-refractory prostate carcinoma (PC) are a pressing medical need. Chronic inflammation has been implicated in PC etiology.
Julia Koerner +4 more
doaj +1 more source
Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease
Redox Biology, 2021 Aberrant α-synuclein (α-Syn) accumulation resulting from proteasome dysfunction is considered as a prominent factor to initiate and aggravate the neurodegeneration in Parkinson's disease (PD).
Mingxia Bi +7 more
doaj +1 more source
On the Role of the Immunoproteasome in Protein Homeostasis
Cells, 2021 Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation.
Michael Basler, Marcus Groettrup
doaj +1 more source
Corneal wound healing is compromised by immunoproteasome deficiency. [PDF]
PLoS ONE, 2013 Recent studies have revealed roles for immunoproteasome in regulating cell processes essential for maintaining homeostasis and in responding to stress and injury.
Deborah A Ferrington +10 more
doaj +1 more source
Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia
Frontiers in Immunology, 2021 The immunoproteasome, a special isoform of the 20S proteasome, is expressed when the cells receive an inflammatory signal. Immunoproteasome inhibition proved efficacy in the treatment of autoimmune diseases.
Sheng-hong Du +18 more
doaj +1 more source