Results 31 to 40 of about 8,916 (246)
Role of Immunoproteasomes in Cross-Presentation [PDF]
The Journal of Immunology, 2006 Abstract The evidence that proteasomes are involved in the processing of cross-presented proteins is indirect and based on the in vitro use of proteasome inhibitors. It remains, therefore, unclear whether cross-presentation of MHC class I peptide epitopes can occur entirely within phagolysosomes or whether it requires proteasome ...
Michael J. Palmowski +10 more
openalex +5 more sources
Pathogenic roles of immunoproteasomes in fibrosis. [PDF]
Essays BiochemThe 26S proteasome is a multi-subunit protease complex that degrades most eukaryotic cellular proteins. It not only regulates individual protein’s half-lives but also maintains proteome homeostasis and modulates immunological responses. During conditions involving large-scale proteome remodeling, such as fibrosis and cellular differentiation, the 26S ...
Kim S, Park SH, Lee MJ.
europepmc +3 more sources
Correction to "Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema via Activating NRF1/2-P62 Axis and Suppressing IRF4 Transcription". [PDF]
Adv Sci (Weinh)Advanced Science, Volume 13, Issue 11, 23 February 2026.
europepmc +2 more sources
Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]
, 2017 A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Aronica, Eleonora +17 more
core +9 more sources
Cell Death and Disease, 2022 Muscle repair in dysferlinopathies is defective. Although macrophage (Mø)-rich infiltrates are prominent in damaged skeletal muscles of patients with dysferlinopathy, the contribution of the immune system to the disease pathology remains to be fully ...
A. Farini +8 more
doaj +1 more source
OncoImmunology, 2023 New treatment options to battle hormone-refractory prostate carcinoma (PC) are a pressing medical need. Chronic inflammation has been implicated in PC etiology.
Julia Koerner +4 more
doaj +1 more source
Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease
Redox Biology, 2021 Aberrant α-synuclein (α-Syn) accumulation resulting from proteasome dysfunction is considered as a prominent factor to initiate and aggravate the neurodegeneration in Parkinson's disease (PD).
Mingxia Bi +7 more
doaj +1 more source
Corneal wound healing is compromised by immunoproteasome deficiency. [PDF]
PLoS ONE, 2013 Recent studies have revealed roles for immunoproteasome in regulating cell processes essential for maintaining homeostasis and in responding to stress and injury.
Deborah A Ferrington +10 more
doaj +1 more source
Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia
Frontiers in Immunology, 2021 The immunoproteasome, a special isoform of the 20S proteasome, is expressed when the cells receive an inflammatory signal. Immunoproteasome inhibition proved efficacy in the treatment of autoimmune diseases.
Sheng-hong Du +18 more
doaj +1 more source
Nature Communications, 2021 The proteasome activator PA28αβ affects MHC class I antigen presentation by associating with immunoproteasome core particles (iCPs). Cryo-EM structures of the mammalian PA28αβ -iCP immunoproteasome and free iCP, combined with cross-linking data, reveal ...
Jinhuan Chen +9 more
doaj +1 more source