Results 31 to 40 of about 5,747 (197)
OncoImmunology, 2023 New treatment options to battle hormone-refractory prostate carcinoma (PC) are a pressing medical need. Chronic inflammation has been implicated in PC etiology.
Julia Koerner +4 more
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Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease
Redox Biology, 2021 Aberrant α-synuclein (α-Syn) accumulation resulting from proteasome dysfunction is considered as a prominent factor to initiate and aggravate the neurodegeneration in Parkinson's disease (PD).
Mingxia Bi +7 more
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Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia
Frontiers in Immunology, 2021 The immunoproteasome, a special isoform of the 20S proteasome, is expressed when the cells receive an inflammatory signal. Immunoproteasome inhibition proved efficacy in the treatment of autoimmune diseases.
Sheng-hong Du +18 more
doaj +1 more source
Nature Communications, 2021 The proteasome activator PA28αβ affects MHC class I antigen presentation by associating with immunoproteasome core particles (iCPs). Cryo-EM structures of the mammalian PA28αβ -iCP immunoproteasome and free iCP, combined with cross-linking data, reveal ...
Jinhuan Chen +9 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundAllergic asthma is a chronic disease and medical treatment often fails to fully control the disease in the long term, leading to a great need for new therapeutic approaches.
Franziska Oliveri +6 more
doaj +1 more source
Immunoproteasome Function in Normal and Malignant Hematopoiesis [PDF]
, 2021 The ubiquitin–proteasome system (UPS) is a central part of protein homeostasis, degrading not only misfolded or oxidized proteins but also proteins with essential functions. The fact that a healthy hematopoietic system relies on the regulation of protein
Elke Krüger +7 more
core +1 more source
Dysfunctional immunoproteasomes in autoinflammatory diseases [PDF]
Inflammation and Regeneration, 2016 Recent progress in DNA sequencing technology has made it possible to identify specific genetic mutations in familial disorders. For example, autoinflammatory syndromes are caused by mutations in gene coding for immunoproteasomes. These diseases include Japanese autoinflammatory syndrome with lipodystrophy, Nakajo-Nishimura syndrome, joint contractures,
Arimochi, Hideki +3 more
openaire +2 more sources
Cells, 2021 Proteasomes are intracellular structures responsible for protein degradation. The 20S proteasome is a core catalytic element of the proteasome assembly.
Elmira Vagapova +8 more
doaj +1 more source
Pathogenic roles of immunoproteasomes in fibrosis. [PDF]
Essays BiochemThe 26S proteasome is a multi-subunit protease complex that degrades most eukaryotic cellular proteins. It not only regulates individual protein’s half-lives but also maintains proteome homeostasis and modulates immunological responses. During conditions involving large-scale proteome remodeling, such as fibrosis and cellular differentiation, the 26S ...
Kim S, Park SH, Lee MJ.
europepmc +3 more sources
Immunoproteasomes: Regulating the regulator [PDF]
Proceedings of the National Academy of Sciences, 2005 I f proteins were people, half of the world's population (3 × 109) would cohabit, cheek by jowl, the typically sized vertebrate cell. Proteins are the most abundant macromolecular constituent of cells and certainly the most important and interesting. Because the interactions of proteins with each other and other cellular components are governed by the ...
openaire +2 more sources