Results 31 to 40 of about 5,882 (203)
Frontiers in Immunology, 2022 BackgroundAllergic asthma is a chronic disease and medical treatment often fails to fully control the disease in the long term, leading to a great need for new therapeutic approaches.
Franziska Oliveri +6 more
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Nature Communications, 2021 The proteasome activator PA28αβ affects MHC class I antigen presentation by associating with immunoproteasome core particles (iCPs). Cryo-EM structures of the mammalian PA28αβ -iCP immunoproteasome and free iCP, combined with cross-linking data, reveal ...
Jinhuan Chen +9 more
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Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease
Redox Biology, 2021 Aberrant α-synuclein (α-Syn) accumulation resulting from proteasome dysfunction is considered as a prominent factor to initiate and aggravate the neurodegeneration in Parkinson's disease (PD).
Mingxia Bi +7 more
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Argyrin B a non-competitive inhibitor of the human immunoproteasome exhibiting preference for β1i [PDF]
, 2019 Inhibitors of the proteasome have found broad therapeutic applications however, they show severe toxicity due to the abundance of proteasomes in healthy cells.
Bell, C., Allardyce, D., Loizidou, E.
core +4 more sources
Dysfunctional immunoproteasomes in autoinflammatory diseases [PDF]
Inflammation and Regeneration, 2016 Recent progress in DNA sequencing technology has made it possible to identify specific genetic mutations in familial disorders. For example, autoinflammatory syndromes are caused by mutations in gene coding for immunoproteasomes. These diseases include Japanese autoinflammatory syndrome with lipodystrophy, Nakajo-Nishimura syndrome, joint contractures,
Arimochi, Hideki +3 more
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Cells, 2021 Proteasomes are intracellular structures responsible for protein degradation. The 20S proteasome is a core catalytic element of the proteasome assembly.
Elmira Vagapova +8 more
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Immunoproteasomes: Regulating the regulator [PDF]
Proceedings of the National Academy of Sciences, 2005 I f proteins were people, half of the world's population (3 × 109) would cohabit, cheek by jowl, the typically sized vertebrate cell. Proteins are the most abundant macromolecular constituent of cells and certainly the most important and interesting. Because the interactions of proteins with each other and other cellular components are governed by the ...
openaire +2 more sources
The Immunoproteasome as a Target in Hematologic Malignancies [PDF]
Seminars in Hematology, 2012 Suppression of proteasome function with the first-in-class small molecule inhibitor bortezomib is a rational therapeutic strategy against several hematologic malignancies, including multiple myeloma and mantle cell lymphoma. Second-generation inhibitors such as carfilzomib, ixazomib, and marizomib that, like bortezomib, target both the constitutive ...
Deborah J, Kuhn, Robert Z, Orlowski
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Discovery of selective fragment-sized immunoproteasome inhibitors
, 2021 Proteasomes contribute to maintaining protein homeostasis and their inhibition is beneficial in certain types of cancer and in autoimmune diseases. However, the inhibition of the proteasomes in healthy cells leads to unwanted side-effects and significant
Imre, Tímea +23 more
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Discovery and Early Clinical Development of Selective Immunoproteasome Inhibitors
Cells, 2021 Inhibitors of the proteolytic activity of the 20S proteasome have transformed the treatment of multiple B-cell malignancies. These agents have also been employed with success in the treatment of patients with autoimmune diseases and immune-mediated ...
Christopher J. Kirk +3 more
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