Results 51 to 60 of about 5,747 (197)
PDGF-D-induced immunoproteasome activation and cell-cell interactions
Computational and Structural Biotechnology Journal, 2023 Platelet-derived growth factor-D (PDGF-D) is abundantly expressed in ocular diseases. Yet, it remains unknown whether and how PDGF-D affects ocular cells or cell-cell interactions in the eye.
Jianing Zhang +9 more
doaj +1 more source
Non-covalent immunoproteasome inhibitors: virtual screening and in vitro test on β1i /β5i subunits
, 2023 Immunoproteasome inhibition is a challenging strategy for the treatment of hematological malignancies, autoimmune and inflammatory diseases [1,2]. The search for non-covalent inhibitors of the immunoproteasome β1i/β5i catalytic subunits could be a new ...
Marco Tutone +6 more
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Frontiers in Immunology, 2023 IntroductionCerebral malaria (CM) lethality is attributable to induction of brain edema induction but the cellular mechanisms involving brain microvascular endothelium in CM pathogenesis are unexplored.ResultsActivation of the STING-INFb-CXCL10 axis in ...
Abdul Muktadir Shafi +8 more
doaj +1 more source
Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis [PDF]
, 2016 In addition to antigen processing, immunoproteasomes were recently shown to exert functions influencing cytokine production by monocytes and T cells, T-helper cell differentiation, and T-cell survival.
Mundt, Sarah +9 more
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iNew Medicine, EarlyView.ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu +2 more
wiley +1 more source
Inhibitors of the immunoproteasome: current status and future directions
, 2013 The ubiquitin-proteasome system (UPS) plays a vital role in maintaining protein homeostasis and regulating numerous cellular processes. The proteasome, a multi-protease complex, is the key component of the UPS and has been validated as a therapeutic ...
Lee, Wooin +3 more
core +1 more source
Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes +7 more
wiley +1 more source
Cell Death and Disease, 2022 Chronic lymphocytic leukemia (CLL) is a hematological neoplasm of CD19-positive mature-appearing B lymphocytes. Despite the clinical success of targeted therapies in CLL, the development of resistance diminishes their therapeutic activity.
Damjan Avsec +6 more
doaj +1 more source
Age-dependent effects of immunoproteasome activity on mouse adenovirus type 1 pathogenesis
, 2023 Acute respiratory infection with mouse adenovirus type 1 (MAV-1) induces activity of the immunoproteasome, an inducible form of the proteasome that shapes CD8 T cell responses by enhancing peptide presentation by major histocompatibility complex (MHC ...
Chandrasekaran, A, Weinberg, JB, Pant, K
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Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Molecular Cancer, 2023 Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance frequently develops to single agents.
Nuria Tubío-Santamaría +25 more
doaj +1 more source