Results 51 to 60 of about 8,916 (246)

Targeting immunoproteasome in neurodegeneration: A glance to the future

Pharmacology & Therapeutics, 2023
The immunoproteasome is a specialized form of proteasome equipped with modified catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen processing and immune system modulation. However, over the last years, this proteolytic complex has been uncovered to serve additional functions unrelated to antigen presentation.
Tundo G. R., Cascio P., Milardi D., Santoro A. M., Graziani G., Lacal P. M., Bocedi A., Oddone F., Parravano M., Coletta A., Coletta M., Sbardella D.   +11 more
openaire   +3 more sources

Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen. [PDF]

, 2020
Ibuprofen, an inhibitor of prostanoid biosynthesis, is a common pharmacological agent used for the management of pain, inflammation and fever. However, the chronic use of ibuprofen at high doses is associated with increased risk for cardiovascular, renal,
Gomes, Aldrin V, Mishra, Manish, Newens, Joanne L, Phinney, Brett S, Salemi, Michelle R, Tiwari, Shuchita   +5 more
core  

Immunoproteasome Function in Normal and Malignant Hematopoiesis [PDF]

Cells, 2021
The ubiquitin–proteasome system (UPS) is a central part of protein homeostasis, degrading not only misfolded or oxidized proteins but also proteins with essential functions. The fact that a healthy hematopoietic system relies on the regulation of protein homeostasis and that alterations in the UPS can lead to malignant transformation makes the UPS an ...
Nuria Tubío-Santamaría, Frédéric Ebstein, Florian H. Heidel, Elke Krüger   +3 more
openaire   +3 more sources

Ubiquitin Proteasom System und Myopathien [PDF]

, 2015
Objective: In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and upregulation of MHC-I expression implies increased antigen presentation and involvement of the proteasome system.
Ghannam, Khetam
core   +1 more source

Synthesis and Biochemical Evaluation of Warhead-Decorated Psoralens as (Immuno)Proteasome Inhibitors

Molecules, 2021
The immunoproteasome is a multicatalytic protease that is predominantly expressed in cells of hematopoietic origin. Its elevated expression has been associated with autoimmune diseases, various types of cancer, and inflammatory diseases.
Eva Shannon Schiffrer, Matic Proj, Martina Gobec, Luka Rejc, Andrej Šterman, Janez Mravljak, Stanislav Gobec, Izidor Sosič   +7 more
doaj   +1 more source

Proteasomal protein degradation: adaptation of cellular proteolysis with impact on virus-and cytokine-mediated damage of heart tissue during myocarditis [PDF]

, 2018
Viral myocarditis is an inflammation of the heart muscle triggered by direct virus-induced cytolysis and immune response mechanisms with most severe consequences during early childhood.
Agarwal, Ajibade, Aki, Akira, Althof, Althof, Arthur, Banks, Barber, Basler, Basler, Basler, Basler, Bitzer, Blasius, Brehm, Caforio, Cascio, Chen, Chow, Chow, Cooper, Corbin-Lickfett, Cornell, Cornell, Corsten, Dantuma, Davidson, De Bruin, De Verteuil, Delboy, Deng, Deol, Deonarain, Dikic, Dimopoulos, Ebstein, Epelman, Ersching, Esfandiarei, Fehling, Feldman, Flynn, Gaczynska, Gaczynska, Gangaplara, Gao, Gebhard, Ginhoux, Godeny, Godeny, Goldberg, Gomes, Goser, Gray, Groll, Groll, Guillaume, Hallermalm, Hallett, Hayashi, Hayashi, Heaton, Henke, Hensley, Hiraoka, Horwitz, Huber, Ichikawa, Jakel, Jakubzick, Jang, Jaquenod De Giusti, Jenne, Jurk, Kalejta, Kalim, Kaspari, Kawai, Kaya, Kemball, Kemball, Kemball, Kessler, Kincaid, Kindermann, Kirschner, Kisselev, Kitamura, Klingel, Klingel, Klingel, Kloetzel, Koerner, Kuhl, Kuhl, La Frazia, Lam, Leipner, Leuschner, Li, Luo, Luo, Macagno, Magrini, Maier, Matsuzaki, Mccarthy, Mccarthy, Mcnab, Mena, Mena, Mercer, Miller, Mishto, Moebius, Muchamuel, Mundt, Mundt, Murata, Murata, Murata, Nebuloni, Nencioni, Neumann, Neznanov, Nussbaum, Opavsky, Opitz, Paeschke, Parlati, Pickart, Pickering, Prösch, Rahnefeld, Rahnefeld, Respondek, Richardson, Richardson, Ronkina, Ros, Rose, Rovere, Runnels, Sagar, Satheshkumar, Scheffner, Schmidt, Schubert, Schwarz, Seifert, Sijts, Spur, Stetson, Stewart, Strehl, Sula Karreci, Szalay, Szalay, Takeda, Takemoto, Tewari, Tian, Triantafilou, Tu, Turnell, Vachharajani, Vankaer, Visekruna, Voigt, Weinzierl, Wessely, Widjaja, Xu, Yun, Zimmermann   +175 more
core   +1 more source

Die Bedeutung des Low Molecular Weight Protein 7 (LMP7)- spezifischen Inhibitors ONX 0914 bei der viralen Infektion der Maus [PDF]

, 2018
Herzinsuffizienz ist eine der häufigsten Todesursachen. Ein Auslöser hierfür kann eine entzündliche Herzerkrankung sein, die durch virale Infektionen beispielsweise mit CoxsackievirusB3 ausgelöst werden können.
Goetzke, Carl Christoph
core   +1 more source

Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease [PDF]

, 2020
The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
Li, Jing, Sherman, David J.
core  

Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7 [PDF]

, 2017
Chronic inflammation is a well-known risk factor in development of intestinal tumorigenesis, although the exact mechanisms underlying development of colitis-associated cancer (CAC) still remain obscure.
Hartmann, Sabrina, Hofer, Markus J, Jenike, Elena, Joeris, Thorsten, Luu, Maik, Pantazis, Georgios, Pautz, Sabine, Prinz, Immo, Steinhoff, Ulrich, Vachharajani, Niyati, Visekruna, Alexander   +10 more
core   +1 more source

PSMB9 codon 60 polymorphisms have no impact on the activity of the immunoproteasome catalytic subunit B1i expressed in multiple types of solid cancer. [PDF]

PLoS ONE, 2013
The proteasome is a key regulator of cellular protein homeostasis and is a clinically validated anticancer target. The immunoproteasome, a subtype of proteasome expressed mainly in hematopoietic cells, was initially recognized for its role in antigen ...
Ji Eun Park, Lin Ao, Zachary Miller, Kyungbo Kim, Ying Wu, Eun Ryoung Jang, Eun Young Lee, Kyung Bo Kim, Wooin Lee   +8 more
doaj   +1 more source