Results 51 to 60 of about 5,882 (203)

Impairment of immunoproteasome function by cigarette smoke and in COPD.

, 2016
RATIONALE: Chronic obstructive pulmonary disease patients and in particular smokers are more susceptible to respiratory infections contributing to acute exacerbations of disease.
Krauss-Etschmann, S., Nathan, P., Brech, D., Meiners, S., Eickelberg, O., Preissler, G., Vosyka, O., Conlon, T.M., Yildirim, A.Ö., Lindner, M., Noessner, E., Overkleeft, H.S., Hatz, R., Hatz, R.A., Nößner, E., Prasse, A., Mossina, A., Rosas, I.O., Winter, H., Behr, J., Kammerl, I.E., Königshoff, M., Wagner, D.E., Lukas, C., Heinzelmann, K., Dann, A., Straub, T.   +26 more
core   +1 more source

Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome [PDF]

, 2017
BACKGROUND AND PURPOSEMulticatalytic endopeptidase complex-like-1 (β2i), low molecular mass polypeptide (LMP) 2 (β1i) and LMP7 (β5i) are the proteolytically active subunits of the immunoproteasome, a special type of proteasome mainly expressed in ...
Overkleeft, H.S., Koerner, J., Basler, M., Julia Koerner, Maurits, E., Herman S Overkleeft, Körner, Julia, Michael Basler, Gerjan de Bruin, Groettrup, M., Elmer Maurits, Bruin, G. de, Maurits, Elmer, Overkleeft, Herman S., Marcus Groettrup, Basler, Michael, de Bruin, Gerjan, de Bruin G, Overkleeft HS, Basler M, Groettrup, Marcus, Maurits E, Koerner J, Groettrup M   +23 more
core   +1 more source

Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates

, 2022
The 26S proteasome irreversibly hydrolyzes polyubiquitylated substrates to maintain protein homeostasis; it also regulates immune responses by generating antigenic peptides.
Lee, Min Jae, Kim, Sumin, Park, Seo Hyeong, Choi, Won Hoon, Won Hoon Choi, Sumin Kim, Min Jae Lee, Seo Hyeong Park   +7 more
core   +1 more source

Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

Nature Communications, 2017
Immunoproteasome selective inhibitors might lead to less toxic drugs for treatment of multiple myeloma and graft rejection. Here, the authors develop immunoproteasome specific asparagine-ethylenediamine (AsnEDA)-based inhibitory compounds, demonstrate ...
Ruda de Luna Almeida Santos, Lin Bai, Pradeep K. Singh, Naoka Murakami, Hao Fan, Wenhu Zhan, Yingrong Zhu, Xiuju Jiang, Kaiming Zhang, Jean Pierre Assker, Carl F. Nathan, Huilin Li, Jamil Azzi, Gang Lin   +13 more
doaj   +1 more source

PDGF-D-induced immunoproteasome activation and cell-cell interactions

Computational and Structural Biotechnology Journal, 2023
Platelet-derived growth factor-D (PDGF-D) is abundantly expressed in ocular diseases. Yet, it remains unknown whether and how PDGF-D affects ocular cells or cell-cell interactions in the eye.
Jianing Zhang, Wanhong Li, Zhen Xiong, Juanhua Zhu, Xiangrong Ren, Shasha Wang, Haiqing Kuang, Xianchai Lin, Antonio Mora, Xuri Li   +9 more
doaj   +1 more source

Brain endothelial cells exposure to malaria parasites links type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption, and cellular metabolism

Frontiers in Immunology, 2023
IntroductionCerebral malaria (CM) lethality is attributable to induction of brain edema induction but the cellular mechanisms involving brain microvascular endothelium in CM pathogenesis are unexplored.ResultsActivation of the STING-INFb-CXCL10 axis in ...
Abdul Muktadir Shafi, Ákos Végvári, Ákos Végvári, Shanshan Wu Howland, Roman A. Zubarev, Laurent Rénia, Laurent Rénia, Laurent Rénia, Carlos Penha-Gonçalves   +8 more
doaj   +1 more source

SERPINB9 Promotes Colorectal Cancer Liver Metastasis and Immunotherapy Resistance: Association With MHC‐I Downregulation and CD8+ T Cell Dysfunction

Medicine Bulletin, EarlyView.
ABSTRACT Background Colorectal cancer liver metastasis (CRLM) is the leading cause of mortality in colorectal cancer (CRC) patients, for which effective treatments remain limited. The mechanisms by which tumor cells evade immune surveillance and escape cytotoxic killing remain poorly understood.
Xin Liu, Wenchen Wang, Hongqian Wang, Yanshen Kuang, Baoqing Jia   +4 more
wiley   +1 more source

Selective Immunoproteasome Inhibitors with Non-Peptide Scaffolds [PDF]

, 2017
Compounds useful for inhibiting the immunoproteasome have the formula of [image on patent]. Methods and compounds for inhibiting the immunoproteasome, particularly, immunoproteasome inhibitors with non-peptide scaffolds, are ...
Zhan, Chang-Guo, Lee, Na-Re, Kasam, Vinod, Kim, Kyung Bo   +3 more
core  

Immunoproteasome Inhibition Impairs Differentiation but Not Survival of T Helper 17 Cells

Cells
Autoimmune and inflammatory diseases are characterized by aberrant immune responses. The immunoproteasome was proposed as a target for such Th cell-mediated diseases due to its role in the activation, differentiation and function of T cells.
Franziska Oliveri, Dennis Mink, Tony Muchamuel, Michael Basler   +3 more
doaj   +1 more source

Inhibition of p38 MAPK or immunoproteasome overcomes resistance of chronic lymphocytic leukemia cells to Bcl-2 antagonist venetoclax

Cell Death and Disease, 2022
Chronic lymphocytic leukemia (CLL) is a hematological neoplasm of CD19-positive mature-appearing B lymphocytes. Despite the clinical success of targeted therapies in CLL, the development of resistance diminishes their therapeutic activity.
Damjan Avsec, Marja Škrlj Miklavčič, Tilen Burnik, Maša Kandušer, Maruša Bizjak, Helena Podgornik, Irena Mlinarič-Raščan   +6 more
doaj   +1 more source