Results 71 to 80 of about 5,882 (203)

The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi. [PDF]

PLoS Pathogens, 2016
The β1i, β2i and β5i immunoproteasome subunits have an important role in defining the repertoire of MHC class I-restricted epitopes. However, the impact of combined deficiency of the three immunoproteasome subunits in the development of protective ...
Jonatan Ersching, José R Vasconcelos, Camila P Ferreira, Braulia C Caetano, Alexandre V Machado, Oscar Bruna-Romero, Monique A Baron, Ludmila R P Ferreira, Edécio Cunha-Neto, Kenneth L Rock, Ricardo T Gazzinelli, Maurício M Rodrigues   +11 more
doaj   +1 more source

The Functional and Mechanistic Roles of Immunoproteasome Subunits in Cancer

Cells, 2021
Cell-mediated immunity is driven by antigenic peptide presentation on major histocompatibility complex (MHC) molecules. Specialized proteasome complexes called immunoproteasomes process viral, bacterial, and tumor antigens for presentation on MHC class I
Satyendra Chandra Tripathi, Disha Vedpathak, Edwin Justin Ostrin   +2 more
doaj   +1 more source

Interferon‐γ Mitigates Oxaliplatin‐Induced Neurotoxicity: Analogies With Connexin 43

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
IFN‐γ mitigates oxaliplatin‐induced neurotoxicity by reducing neuroinflammation and neuronal excitability, suggesting a protective mechanism involving Cx43 modulation and potential therapeutic value in chemotherapy‐induced neurotoxicity. ABSTRACT Aims Chemotherapy‐induced neuropathy is a major side effect of platinum‐based drugs such as oxaliplatin ...
Alessandra Toti, Valentina Ferrara, Elena Lucarini, Laura Micheli, Clara Ciampi, Francesco Margiotta, Daniel Venturi, Carmen Parisio, Elisabetta Gerace, Lorenzo Curti, Alessio Masi, Tommaso Mello, Guido Mannaioni, Carla Ghelardini, Lorenzo Di Cesare Mannelli   +14 more
wiley   +1 more source

Activity-Based Near-Infrared Fluorescent Probe for LMP7: A Chemical Proteomics Tool for the Immunoproteasome in Living Cells

, 2012
Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases.
Lee, Na-Ra, Zhan, Chang-Guo, Sharma, Lalit Kumar, Lee, Wooin, Lei, Beilei, Kim, Kyung-Bo, Jang, Eun Ryoung   +6 more
core   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Age-dependent effects of immunoproteasome activity on mouse adenovirus type 1 pathogenesis

, 2023
Acute respiratory infection with mouse adenovirus type 1 (MAV-1) induces activity of the immunoproteasome, an inducible form of the proteasome that shapes CD8 T cell responses by enhancing peptide presentation by major histocompatibility complex (MHC ...
Chandrasekaran, A, Weinberg, JB, Pant, K
core   +1 more source

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

Rethinking the Oligodendrocyte Progenitor Cell: One Cell, Many Functions

European Journal of Neuroscience, Volume 64, Issue 7, October 2026.
Oligodendrocyte progenitor cells (OPCs) are increasingly recognised as multifunctional CNS cells rather than mere precursors of myelinating oligodendrocytes. Alongside myelination and remyelination, they contribute to myelin and circuit plasticity, circuit regulation, vascular and blood–brain barrier regulation and neuroimmune modulation.
Alerie G. de la Fuente
wiley   +1 more source

Immunoproteasomes Are Important for Proteostasis in Immune Responses [PDF]

Cell, 2013
Document S1. Extended Experimental ProceduresxDownload (.11 MB ) Document S1.
Ebstein, Frédéric, Voigt, Antje, Lange, Nicole, Warnatsch, Annika, Schröter, Friederike, Prozorovski, Timour, Kuckelkorn, Ulrike, Aktas, Orhan, Seifert, Ulrike, Kloetzel, Peter M., Krüger, Elke   +10 more
openaire   +3 more sources

Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome

iMetaOmics, Volume 3, Issue 3, September 2026.
A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo, Huacheng Wang, Meili Gao, Chao Qin, Ke Zhu, Yun Leng, Kamran Ullah, Jun Liang, Haiyan Yan, Guan Yang, Yingqian Mo, Bihui Huang   +20 more
wiley   +1 more source