Results 91 to 100 of about 5,882 (203)

Structural T‐Cell Receptor Analysis in the Age of Machine Learning

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT The development of highly accurate deep learning models for protein structure prediction has transformed the landscape of T‐cell receptor (TCR) structure data, which can now be accessed at repertoire scale. We provide a perspective on the growing field of structural TCR immunoinformatics, summarizing core principles of TCR structural biology ...
Nele P. Quast, Matthew I. J. Raybould, Charlotte M. Deane   +2 more
wiley   +1 more source

Immunoproteasome in cancer and neuropathologies: a new therapeutic target?

, 2013
Immunoproteasome is an emerging biological target that constitutes a key element not only in antigen presentation but also in T cell and cytokine regulation as well as cellular homeostasis.
BELLAVISTA, ELENA, PARENTI, MARCO DANIELE, MISHTO, MICHELE, FRANCESCHI, CLAUDIO, MARTUCCI, MORENA, SALVIOLI, STEFANO, DEL RIO, ALBERTO, SANTORO, AURELIA, BARUZZI, AGOSTINO, ANDREOLI, FEDERICO, CAPRI, MIRIAM   +10 more
core   +1 more source

Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome

, 2015
Selective inhibitors for the human immunoproteasome LMP7 (β5i) subunit over the constitutive proteasome hold promise for the treatment of autoimmune and inflammatory diseases and hematologic malignancies.
Hao Fan (251031), Nicholas G. Angelo (1314942), Gang Lin (824266), Carl F. Nathan (235509), J. David Warren (439659)   +4 more
core   +1 more source

Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema Via Activating NRF1/2‐P62 Axis and Suppressing IRF4 Transcription

Advanced Science
Chronic obstructive pulmonary disease (COPD) stands as the prevailing chronic airway ailment, characterized by chronic bronchitis and emphysema. Current medications fall short in treatment of these diseases, underscoring the urgent need for effective ...
Bingxin Guo, Xing Shi, Qiong Jiang, Yuanwei Pan, Yuqiong Yang, Yuanyuan Liu, Shuyu Chen, Wenjiao Zhu, Laibin Ren, Ruifang Liang, Xue Chen, Haizhao Xu, Laiyou Wei, Yongjian Lin, Jinyong Wang, Chen Qiu, Haibo Zhou, Lang Rao, Lingwei Wang, Rongchang Chen, Shanze Chen   +20 more
doaj   +1 more source

Subversion of immunoproteasome subunit expression in dengue virus serotype 2-infected HepG2 cells

Revista da Sociedade Brasileira de Medicina Tropical
: INTRODUCTION: Infection with all serotypes of dengue virus (DV) results in augmented antigen presentation by MHC class I molecules. However, the upregulation of immunoproteasome subunits only results from infection with two serotypes. This study aims
Chye Sheng Gan, Pei Jean Lim, Muhammad Fazril Mohamad Razif, Rohana Yusof, Shatrah Othman   +4 more
doaj   +1 more source

Immune and non-immune functions of the immunoproteasome

Frontiers in Bioscience, 2012
The biological importance of the ubiquitin-proteasome system in the control of myriad cellular processes has been well-recognized; however, the pathophysiological significance of the immunoproteasome, the inducible form of the proteasome, has not been well-comprehended until lately.
Arkhjamil, Angeles, Gabriel, Fung, Honglin, Luo   +2 more
openaire   +2 more sources

Identifying novel roles for the immunoproteasome in the retina.

, 2010
University of Minnesota Ph.D. dissertation. October 2010. Major: Biochemistry, Molecular Bio, and Biophysics. Advisors: Dr. Deborah A. Ferrington, Ph.D., 1 computer file (PDF); xii, 204 pages, appendix p. 200-204.Immunoproteasome is a proteasome sub-type
Hussong, Stacy Ann
core  

Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits.

PLoS Biology
Defective autophagy is linked to proinflammatory diseases. However, the mechanisms by which autophagy limits inflammation remain elusive. Here, we found that the pan-FGFR inhibitor LY2874455 efficiently activated autophagy and suppressed expression of ...
Jiao Zhou, Chunxia Li, Meng Lu, Gaoyue Jiang, Shanze Chen, Huihui Li, Kefeng Lu   +6 more
doaj   +1 more source

Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells.

PLoS ONE, 2013
Autoimmune destruction of insulin producing pancreatic β-cells is the hallmark of type I diabetes. One of the key molecules implicated in the disease onset is the immunoproteasome, a protease with multiple proteolytic sites that collaborates with the ...
Wieke Freudenburg, Madhav Gautam, Pradipta Chakraborty, Jared James, Jennifer Richards, Alison S Salvatori, Aaron Baldwin, Jill Schriewer, R Mark L Buller, John A Corbett, Dorota Skowyra   +10 more
doaj   +1 more source

Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

EBioMedicine, 2018
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders.
Scott Ugras, Malcolm J. Daniels, Hossein Fazelinia, Neal S. Gould, Anastasia K. Yocum, Kelvin C. Luk, Esteban Luna, Hua Ding, Chris McKennan, Steven Seeholzer, Dan Martinez, Perry Evans, Daniel Brown, John E. Duda, Harry Ischiropoulos   +14 more
doaj   +1 more source