The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi. [PDF]
PLoS Pathogens, 2016 The β1i, β2i and β5i immunoproteasome subunits have an important role in defining the repertoire of MHC class I-restricted epitopes. However, the impact of combined deficiency of the three immunoproteasome subunits in the development of protective ...
Jonatan Ersching +11 more
doaj +1 more source
The Functional and Mechanistic Roles of Immunoproteasome Subunits in Cancer
Cells, 2021 Cell-mediated immunity is driven by antigenic peptide presentation on major histocompatibility complex (MHC) molecules. Specialized proteasome complexes called immunoproteasomes process viral, bacterial, and tumor antigens for presentation on MHC class I
Satyendra Chandra Tripathi +2 more
doaj +1 more source
Lipopolysacharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus [PDF]
, 2012 BACKGROUND: Neuroinflammation and protein accumulation are characteristic hallmarks of both normal aging and age-related neurodegenerative diseases. However, the relationship between these factors in neurodegenerative processes is poorly understood.
Castaño Navarro, Angélica +8 more
core +2 more sources
An effective method studies the β5 subunit activity of immunoproteasome in vitro [PDF]
, 2022 Hengjuan Lv, Yue Hui, DAN FU
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Advanced Science, Volume 13, Issue 16, 18 March 2026.CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan +10 more
wiley +1 more source
A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus.
PLoS ONE, 2011 Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates and immunocompromised adults.
Sarah Hutchinson +6 more
doaj +1 more source
Structural bases for MHC class I peptide selection and neoepitope formation [PDF]
, 2018 One task of the immune system is to distinguish between healthy cells and altered cells due to viruses or cancers. To achieve this CD8+ T-cells are constantly monitoring the Major histocompatibility class I (MHC-I) complexes expressed on all nucleated ...
Hafstrand, Ida
core +1 more source
Gemcitabine alters the proteasome composition and immunopeptidome of tumour cells [PDF]
, 2018 The antigenic makeup of tumour cells can have a profound effect on the progression of cancer and success of immunotherapies. Therefore, one strategy to improve the efficacy of cancer treatments is to augment the antigens displayed by tumours. The present
Copier, J +4 more
core +1 more source
Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders
Advanced Science, Volume 13, Issue 12, 27 February 2026.Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li +7 more
wiley +1 more source
A Cell-Based Platform for the Investigation of Immunoproteasome Subunit β5i Expression and Biology of β5i-Containing Proteasomes [PDF]
, 2021 А. В. Буров +14 more
openalex +1 more source