Results 91 to 100 of about 5,747 (197)

Immunoproteasome deficiency results in age-dependent development of epilepsy

The immunoproteasome is a central protease complex required for optimal antigen presentation. Immunoproteasome activity is also associated with facilitating the degradation of misfolded and oxidized proteins, which prevents cellular stress.
Hanna Leister (13880143), Inna Prus (14246942), Michael A Farrell (7953308), Alexander Visekruna (154426), Rogerio Da Rosa Gerbatin (17956281), Frederik Helmprobst (3618095), Donncha O'Brien (7898714), Felix F Krause (17956272), Axel Pagenstecher (67180), David Henshall (7895351), Ulrich Steinhoff (154431), Beatriz Gil (5594783), Norman Delanty (7895990), Francesca Brett (7899011), Alan Beausang (12816747), Ruslan Prus (14157009), Anne Hellhund-Zingel (17956274), Meghma Mitra (14157000), Jane Cryan (10045865), Tobias Engel (7896263)   +19 more
core   +5 more sources

Immunoproteasome expression is induced in mesial temporal lobe epilepsy.

, 2011
Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of ...
BELLAVISTA, ELENA, Elena Bellavista, FRANCESCHI, CLAUDIO, Michele Mishto, Marco Giulioni, SANTORO, AURELIA, GIULIONI, MARCO, Claudia Ligorio, MISHTO, MICHELE, MARUCCI, GIANLUCA, Morena Martucci, Aurelia Santoro, Gianluca Marucci, LIGORIO, CLAUDIA, MARTUCCI, MORENA, Claudio Franceschi   +15 more
core   +1 more source

Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells.

PLoS ONE, 2013
Autoimmune destruction of insulin producing pancreatic β-cells is the hallmark of type I diabetes. One of the key molecules implicated in the disease onset is the immunoproteasome, a protease with multiple proteolytic sites that collaborates with the ...
Wieke Freudenburg, Madhav Gautam, Pradipta Chakraborty, Jared James, Jennifer Richards, Alison S Salvatori, Aaron Baldwin, Jill Schriewer, R Mark L Buller, John A Corbett, Dorota Skowyra   +10 more
doaj   +1 more source

Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome

, 2015
Selective inhibitors for the human immunoproteasome LMP7 (β5i) subunit over the constitutive proteasome hold promise for the treatment of autoimmune and inflammatory diseases and hematologic malignancies.
Hao Fan (251031), Nicholas G. Angelo (1314942), Gang Lin (824266), Carl F. Nathan (235509), J. David Warren (439659)   +4 more
core   +1 more source

Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits.

PLoS Biology
Defective autophagy is linked to proinflammatory diseases. However, the mechanisms by which autophagy limits inflammation remain elusive. Here, we found that the pan-FGFR inhibitor LY2874455 efficiently activated autophagy and suppressed expression of ...
Jiao Zhou, Chunxia Li, Meng Lu, Gaoyue Jiang, Shanze Chen, Huihui Li, Kefeng Lu   +6 more
doaj   +1 more source

Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

EBioMedicine, 2018
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders.
Scott Ugras, Malcolm J. Daniels, Hossein Fazelinia, Neal S. Gould, Anastasia K. Yocum, Kelvin C. Luk, Esteban Luna, Hua Ding, Chris McKennan, Steven Seeholzer, Dan Martinez, Perry Evans, Daniel Brown, John E. Duda, Harry Ischiropoulos   +14 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Immunoproteasomes [PDF]

, 2012
Deborah A. Ferrington, Dale S. Gregerson
openaire   +2 more sources

Dysregulation of immunoproteasomes in autoinflammatory syndromes

International Immunology, 2018
Abstract Immunoproteasomes degrade ubiquitin-coupled proteins and play a role in creating peptides for presentation by MHC class I proteins. Studies of gene-deficient mice, in which each immunoproteasomal subunit was affected, have demonstrated that dysfunction of immunoproteasomes leads to immunodeficiency, i.e.
openaire   +2 more sources

Recent Advances in the Development of Immunoproteasome Inhibitors as Anti-Cancer Agents: The Past 5 Years

Molecules
The immunoproteasome (iCP) is an isoform of the 20S proteasome that is expressed in response to cellular stress or inflammatory stimuli. The primary role of the iCP is to hydrolyze proteins into peptides that can be loaded into the MHC-I complex.
Francesca Mancuso, Carla Di Chio, Francesca Di Matteo, Gerardina Smaldone, Nunzio Iraci, Salvatore Vincenzo Giofrè   +5 more
doaj   +1 more source