Results 111 to 120 of about 8,916 (246)
The Scientific World Journal, Volume 2026, Issue 1, 2026.Eukaryotic elongation factor 1‐alpha‐2 (eEF1A2) is a neuron‐ and muscle‐specific translation elongation factor isoform that supports high‐demand proteostasis in terminally differentiated cells. Beyond its canonical role in translation elongation, eEF1A2 participates in noncanonical processes linked to actin cytoskeleton regulation, compartmentalized ...
Kawinthra Khwanraj +3 more
wiley +1 more source
Noxa Increases Assembly of Immunoproteasome to Block the Development of COPD [PDF]
, 2021 Z.H. Negasi +3 more
openalex +1 more source
Molecular Oncology, Volume 19, Issue 12, Page 3729-3749, December 2025.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Putting it all together: intrinsic and extrinsic mechanisms governing proteasome biogenesis [PDF]
, 2017 Background The 26S proteasome is at the heart of the ubiquitin-proteasome system, which is the key cellular pathway for the regulated degradation of proteins and enforcement of protein quality control.
Howell, Lauren A. +2 more
core +1 more source
Targeted Therapy for Idiopathic Inflammatory Myopathy
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.ABSTRACT Background Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune disorders characterized by chronic muscle inflammation and significant extramuscular involvement. A substantial proportion of patients exhibit refractory or relapsing disease despite conventional immunosuppressive therapies, necessitating the ...
Ruijie Wang +3 more
wiley +1 more source
Dysregulation of immunoproteasomes in autoinflammatory syndromes
International Immunology, 2018 Abstract Immunoproteasomes degrade ubiquitin-coupled proteins and play a role in creating peptides for presentation by MHC class I proteins. Studies of gene-deficient mice, in which each immunoproteasomal subunit was affected, have demonstrated that dysfunction of immunoproteasomes leads to immunodeficiency, i.e.
openaire +2 more sources
Immune and non-immune functions of the immunoproteasome
Frontiers in Bioscience, 2012 The biological importance of the ubiquitin-proteasome system in the control of myriad cellular processes has been well-recognized; however, the pathophysiological significance of the immunoproteasome, the inducible form of the proteasome, has not been well-comprehended until lately.
Arkhjamil, Angeles +2 more
openaire +2 more sources
CellsIntracerebral hemorrhage induces severe secondary brain injury characterized by excessive neuroinflammation and inefficient hematoma clearance, processes largely governed by microglial polarization and phagocytic activity.
Wei-Fen Hu +9 more
doaj +1 more source
Update in juvenile myositis. [PDF]
, 2013 This update on childhood idiopathic inflammatory myopathies (IIMs) reviews recent progress in the field of translational science and clinical research over the past 12-18 ...
Nistala, K, Wedderburn, LR
core +1 more source
The Role of Immunoproteasomes in Tumor-Immune Cell Interactions in Melanoma and Colon Cancer [PDF]
, 2022 Hanna Leister +4 more
openalex +1 more source