Results 111 to 120 of about 5,882 (203)

Revisiting the role of the immunoproteasome in the activation of the canonical NF-kappa B pathway

, 2012
The discovery of NF-kappa B signaling pathways has greatly enhanced our understanding of inflammatory and immune responses. In the canonical NF-kappa B pathway, the proteasomal degradation of I kappa B alpha, an inhibitory protein of NF-kappa B, is ...
Lee, Na-Ra, Hong, Jin Tae, Lee, Do-Min, Wehenkel, Marie, Han, Songhee, Kim, Kyung Bo, Carmony, Kimberly Cornish, Marks, James, Sharma, Lalit Kumar, Lee, Wooin, Jang, Eun Ryoung, Wu, Ying, Ban, Jung-Ok   +12 more
core   +1 more source

The role of the immunoproteasome in interferon-γ-mediated microglial activation

, 2017
Microglia regulate the brain microenvironment by sensing damage and neutralizing potentially harmful insults. Disruption of central nervous system (CNS) homeostasis results in transition of microglia to a reactive state characterized by morphological ...
Gauthaman Sukumar, Clifton L. Dalgard, Barrington G. Burnett, Mahlet B. Abera, Young J. Yauger, Kasey E. Moritz, Nikki M. McCormack, Coralie Viollet   +7 more
core   +1 more source

LY2874455 reduced the protein levels of immunoproteasome-specific subunits in LPS-stimulated macrophages.

(A) Above, method diagram of mass spectrometry-based proteomics analysis of RAW264.7 cells treated with LPS (20 ng/ml) or/and LY2874455. The original mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE ...
Gaoyue Jiang (18115410), Shanze Chen (3524258), Kefeng Lu (9282707), Meng Lu (271376), Huihui Li (227521), Jiao Zhou (2937987), Chunxia Li (182841)   +6 more
core   +1 more source

Substrate secondary structure is associated with proteasomal cleavage propensity. [PDF]

Front Bioinform
Gutierres MBB, Beruldsen F, Antunes DA, Vieira GF.   +3 more
europepmc   +1 more source

The 19S proteasome as a therapeutic target in hematologic malignancies. [PDF]

Front Cell Dev Biol
Olivas IM, Gonzalez-Henry MA, Darvishi S, Esparza EM, Eiring AM.   +4 more
europepmc   +1 more source

Erratum for Steigmann et al., "Effects of immunoproteasome inhibition on acute respiratory infection with murine hepatitis virus strain 1". [PDF]

J Virol
Steigmann JC, Zhou X, Suttenberg LN, Salman I, Rehmathullah ZF, Weinberg JB.   +5 more
europepmc   +1 more source

Sweet Syndrome Beyond the Neutrophil. [PDF]

Exp Dermatol
Nakamizo S.
europepmc   +1 more source

Pan-cancer analysis identifies immunoproteasome as the predominant survival-associated component of antigen processing machinery. [PDF]

Transl Oncol
Lai JI, Liu CY, Tsai YF, Huang CC, Tseng LM, Chao TC.   +5 more
europepmc   +1 more source

Immunoproteasome deficiency results in age-dependent development of epilepsy

The immunoproteasome is a central protease complex required for optimal antigen presentation. Immunoproteasome activity is also associated with facilitating the degradation of misfolded and oxidized proteins, which prevents cellular stress.
Hanna Leister (13880143), Inna Prus (14246942), Michael A Farrell (7953308), Alexander Visekruna (154426), Rogerio Da Rosa Gerbatin (17956281), Frederik Helmprobst (3618095), Donncha O'Brien (7898714), Felix F Krause (17956272), Axel Pagenstecher (67180), David Henshall (7895351), Ulrich Steinhoff (154431), Beatriz Gil (5594783), Norman Delanty (7895990), Francesca Brett (7899011), Alan Beausang (12816747), Ruslan Prus (14157009), Anne Hellhund-Zingel (17956274), Meghma Mitra (14157000), Jane Cryan (10045865), Tobias Engel (7896263)   +19 more
core   +2 more sources

A Novel Dominantly Segregating PSMB10 Splice-Site Variant in Familial Autoinflammatory Disease with Immunoproteasome and Interferon-Related Dysregulation. [PDF]

Genes (Basel)
Onat UI, Bülbül A, Sigli D, Sever EA, Ugurlu S, Ozdogan AH, Tahir Turanli E.   +6 more
europepmc   +1 more source