Results 131 to 140 of about 8,916 (246)

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena, Danilova, Nadia, Lin, Shuo, Sakamoto, Kathleen M, Wilkes, Mark, Youn, Min-Young   +5 more
core   +2 more sources

Immunoproteasomes Are Essential for Clearance of Listeria monocytogenes in Nonlymphoid Tissues but Not for Induction of Bacteria-Specific CD8+ T Cells [PDF]

, 2006
Britta Strehl, Thorsten Joeris, Melanie Rieger, Alexander Visekruna, Kathrin Textoris‐Taube, Stefan H. E. Kaufmann, Peter‐Michael Kloetzel, Ulrike Kuckelkorn, Ulrich Steinhoff   +8 more
openalex   +1 more source

Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits.

PLoS Biology
Defective autophagy is linked to proinflammatory diseases. However, the mechanisms by which autophagy limits inflammation remain elusive. Here, we found that the pan-FGFR inhibitor LY2874455 efficiently activated autophagy and suppressed expression of ...
Jiao Zhou, Chunxia Li, Meng Lu, Gaoyue Jiang, Shanze Chen, Huihui Li, Kefeng Lu   +6 more
doaj   +1 more source

Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells.

PLoS ONE, 2013
Autoimmune destruction of insulin producing pancreatic β-cells is the hallmark of type I diabetes. One of the key molecules implicated in the disease onset is the immunoproteasome, a protease with multiple proteolytic sites that collaborates with the ...
Wieke Freudenburg, Madhav Gautam, Pradipta Chakraborty, Jared James, Jennifer Richards, Alison S Salvatori, Aaron Baldwin, Jill Schriewer, R Mark L Buller, John A Corbett, Dorota Skowyra   +10 more
doaj   +1 more source

Reply [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108083/1/hep26952 ...
Omary, M. Bishr, Snider, Natasha T.
core   +1 more source

Oxidative stress regulates the ubiquitin–proteasome system and immunoproteasome functioning in a mouse model of X-adrenoleukodystrophy [PDF]

, 2013
Nathalie Launay, Montserrat Ruíz, Stéphane Fourcade, Agatha Schlüter, Cristina Guilera, Isidró Ferrer, Erwin Knecht, Aurora Pujol   +7 more
openalex   +1 more source

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. I. Effect of Lipopolysaccharide on Innate Immunity [PDF]

, 2015
The dysregulation of endometrial immune response to bacterial lipopolysaccharide (LPS) has been implicated in uterine disease and infertility in the postpartum dairy cow, although the mechanisms are not clear.
Abudureyimu, A, Cheng, Z R, Fouladi-Nashta, A A, Oguejiofor, C F, Wathes, D C   +4 more
core   +2 more sources

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors [PDF]

, 2008
Deborah J. Kuhn, Sally A. Hunsucker, Qing Chen, Peter M. Voorhees, Marian Orłowski, Robert Z. Orlowski   +5 more
openalex   +1 more source

Immunoproteasomes [PDF]

, 2012
Deborah A. Ferrington, Dale S. Gregerson
openaire   +2 more sources

Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice [PDF]

, 2021
Jamilah Abusarah, Fatemeh Khodayarian, Nehmé El-Hachem, Natasha Salame, Martin Olivier, Mohammad Balood, Katiane Roversi, Sébastien Talbot, Jean‐Pierre Bikorimana, Jingkui Chen, Mario Jolicœur, Louis‐Éric Trudeau, Samaneh Kamyabiazar, Borhane Annabi, Françis Robert, Jerry Pelletier, Abed-El-Hakim El-Kadiry, Riam Shammaa, Moutih Rafei   +18 more
openalex   +1 more source