Results 151 to 160 of about 5,747 (197)

Immunoproteasome inhibition triggers protein stress and apoptosis in cells of B cell lineage without impairing vaccination-induced antibody responses. [PDF]

Cell Death Discov
Mink D, Oliveri F, Otto J, Kutsi N, Gonzalez Siebold C, Muchamuel T, Li J, Basler M.   +7 more
europepmc   +1 more source

Chronic IFN-γ Exposure Induces Divergent Adaptive Programs in Glioblastoma Subtypes. [PDF]

Cancers (Basel)
Rahbarlayegh E, Nomura N, Juarez TM, Kesari PR, Kesari S.   +4 more
europepmc   +1 more source

The immunoproteasome regulates ILC2 responses by modulating mitochondrial capacity. [PDF]

Proc Natl Acad Sci U S A
Laurent P, Chaudhary V, Li D, Ah Kioon MD, Zhang C, Miller WH, Liao H, Lin G, Nathan CF, Barrat FJ.   +9 more
europepmc   +1 more source

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Immunoproteasomes and immunosenescence

Ageing Research Reviews, 2003
Aging is a complex process which is accompanied with the decline and the reshaping of different functions of the body. In particular the immune system is characterized, during ageing (immunosenescence) by a remodeling of innate immunity (well preserved, up-regulated) and clonotypical immunity (severely altered) and by the occurrence of a chronic ...
Mishto M., Santoro A., Bellavista E., Bonafe M., Monti D., Franceschi C.   +5 more
openaire   +3 more sources

Proteasomes and immunoproteasomes.

Rivista di biologia, 2011
In eukaryotic cells, the protein degradation is a highly regulated and selective process. Membrane-associated or extracellular proteins are degraded in lysosomes, whereas intracellular protein dismantling is primarily non-lysosomal, being realized by complex, not-membrane enclosed and energy-dependent effectors, the proteasomes, localized in both ...
Fietta, Pieranna, Delsante, Giovanni
openaire   +2 more sources

The immunoproteasome

American Journal of Transplantation, 2017
Modern treatment strategies for the maintenance of allograft acceptance frequently target ubiquitously-expressed pathways, leading to significant side-effects and poor long-term allograft outcomes. Constitutive proteasome inhibitors, which have recently been introduced for the treatment of antibody-mediated rejection, target the ubiquitously-expressed ...
Eskandari, S. K., Seelen, M. A. J., Lin, G., Azzi, J. R.   +3 more
openaire   +1 more source

A patent review of immunoproteasome inhibitors

Expert Opinion on Therapeutic Patents, 2018
The ubiquitin-proteasome system is responsible for maintaining protein homeostasis and regulating a variety of cellular processes. The constitutive proteasome is expressed in all cells while the immunoproteasome (IP) is predominantly found in cells of hematopoietic origin.
Eva, Ogorevc, Eva Shannon, Schiffrer, Izidor, Sosič, Stanislav, Gobec   +3 more
openaire   +2 more sources

Immunoproteasome as a Target for Prodrugs

Journal of Medicinal Chemistry
Immunoproteasome (iCP) is a proteasome isoform that is expressed under inflammatory conditions such as cytokine interferon-γ exposure. The iCP has different catalytic subunits other than the standard CP (standard core particle), allowing the production of major histocompatibility complex class I (MHC-I) compatible peptides for eventual T-cell ...
Christine S. Muli, Cody A. Loy, Darci J. Trader   +2 more
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Immunoproteasomal Processing of Isolevuglandin Adducts in Hypertension

2023
SUMMARY Abstract Figure Graphical Abstract Isolevuglandins (isoLGs) are lipid aldehydes that form in the presence of reactive oxygen species (ROS) and drive immune activation.
Néstor de la Visitación, Wei Chen, Jaya Krishnan, Justin P. Van Beusecum, Venkataraman Amarnath, Elizabeth M. Hennen, Shilin Zhao, Mohammad Saleem, Mingfang Ao, David G. Harrison, David M. Patrick   +10 more
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Emerging role of immunoproteasomes in pathophysiology

Immunology & Cell Biology, 2016
The immunoproteasome is a proteasome variant that is found only in jawed vertebrates. It is responsible for degrading intracellular proteins to generate a major source of peptides with substantial major histocompatibility complex I binding affinity. The immunoproteasome also has roles in T‐cell survival, differentiation and proliferation in various ...
Gagandeep, Kaur, Sanjay, Batra
openaire   +2 more sources