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Targeting immunoproteasome in neurodegeneration: A glance to the future
Pharmacology & Therapeutics, 2023The immunoproteasome is a specialized form of proteasome equipped with modified catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen processing and immune system modulation. However, over the last years, this proteolytic complex has been uncovered to serve additional functions unrelated to antigen presentation.
Tundo G. R. +11 more
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A patent review of immunoproteasome inhibitors
Expert Opinion on Therapeutic Patents, 2018The ubiquitin-proteasome system is responsible for maintaining protein homeostasis and regulating a variety of cellular processes. The constitutive proteasome is expressed in all cells while the immunoproteasome (IP) is predominantly found in cells of hematopoietic origin.
Eva, Ogorevc +3 more
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Immunoproteasome as a Target for Prodrugs
Journal of Medicinal ChemistryImmunoproteasome (iCP) is a proteasome isoform that is expressed under inflammatory conditions such as cytokine interferon-γ exposure. The iCP has different catalytic subunits other than the standard CP (standard core particle), allowing the production of major histocompatibility complex class I (MHC-I) compatible peptides for eventual T-cell ...
Christine S. Muli +2 more
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Immunoproteasomal Processing of Isolevuglandin Adducts in Hypertension
2023SUMMARY Abstract Figure Graphical Abstract Isolevuglandins (isoLGs) are lipid aldehydes that form in the presence of reactive oxygen species (ROS) and drive immune activation.
Néstor de la Visitación +10 more
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Emerging role of immunoproteasomes in pathophysiology
Immunology & Cell Biology, 2016The immunoproteasome is a proteasome variant that is found only in jawed vertebrates. It is responsible for degrading intracellular proteins to generate a major source of peptides with substantial major histocompatibility complex I binding affinity. The immunoproteasome also has roles in T‐cell survival, differentiation and proliferation in various ...
Gagandeep, Kaur, Sanjay, Batra
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Immunoproteasome-Specific Inhibitors and Their Application
2012Immunoproteasomes (IPs) containing the interferon-inducible subunits β1i (LMP2), β2i (MECL-1), and β5i (LMP7) alter proteasomal cleavage preference, optimise the generation of peptide ligands of MHC class I molecules, alter cytokine profile, influence T-helper cell differentiation, and play a role in T-cell survival.
Michael, Basler, Marcus, Groettrup
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Immunoproteasom: drug development for xenotransplantation
Xenotransplantation, 2012The majority of cellular proteins are degraded by proteasomes within the ubiquitin‐proteasome ATP‐dependent degradation pathway. Products of proteasomal activity are short peptides which are further hydrolysed by proteases to single amino acid. Some peptides though can escape the degradation, being selected and uptaken by MHC class I molecules for ...
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Role of immunoproteasomes and thymoproteasomes in health and disease
Pathology International, 2021The proteasome is a multisubunit protease that degrades intracellular proteins into small peptides. Besides playing a pivotal role in many cellular processes indispensable for survival, it is involved in the production of peptides presented by major histocompatibility complex class I molecules.
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Modulation of immunoproteasome subunits by liposomal lipid A
Vaccine, 2008Liposomes are phospholipid vesicles that have been used as carriers of antigens and adjuvants. Lipid A, the endotoxic moiety of Gram-negative bacterial lipopolysaccharide is a potent adjuvant and incorporation into liposomes essentially reduces the endotoxic activity of lipid A.
Nicholas J, Steers +2 more
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