Results 161 to 170 of about 5,747 (197)
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Immunoproteasome-Specific Inhibitors and Their Application
2012Immunoproteasomes (IPs) containing the interferon-inducible subunits β1i (LMP2), β2i (MECL-1), and β5i (LMP7) alter proteasomal cleavage preference, optimise the generation of peptide ligands of MHC class I molecules, alter cytokine profile, influence T-helper cell differentiation, and play a role in T-cell survival.
Michael, Basler, Marcus, Groettrup
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Immunoproteasom: drug development for xenotransplantation
Xenotransplantation, 2012The majority of cellular proteins are degraded by proteasomes within the ubiquitin‐proteasome ATP‐dependent degradation pathway. Products of proteasomal activity are short peptides which are further hydrolysed by proteases to single amino acid. Some peptides though can escape the degradation, being selected and uptaken by MHC class I molecules for ...
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Role of immunoproteasomes and thymoproteasomes in health and disease
Pathology International, 2021The proteasome is a multisubunit protease that degrades intracellular proteins into small peptides. Besides playing a pivotal role in many cellular processes indispensable for survival, it is involved in the production of peptides presented by major histocompatibility complex class I molecules.
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Modulation of immunoproteasome subunits by liposomal lipid A
Vaccine, 2008Liposomes are phospholipid vesicles that have been used as carriers of antigens and adjuvants. Lipid A, the endotoxic moiety of Gram-negative bacterial lipopolysaccharide is a potent adjuvant and incorporation into liposomes essentially reduces the endotoxic activity of lipid A.
Nicholas J, Steers +2 more
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DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity
EMBO Journal, 2023Fabian Hauck +2 more
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A Novel Mechanism of Immunoproteasome Regulation via miR-369-3p in Intestinal Inflammatory Response
International Journal of Molecular Sciences, 2022Viviana Scalavino +2 more
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Upregulation of immunoproteasome PSMB8 is associated with Parkinson’s disease
Parkinsonism and Related Disorders, 2023Hyeo-Il Ma +2 more
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Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity
EMBO Reports, 2018Herman Overkleeft +2 more
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