Results 101 to 110 of about 5,882 (203)
Dysregulation of immunoproteasomes in autoinflammatory syndromes
International Immunology, 2018 Abstract Immunoproteasomes degrade ubiquitin-coupled proteins and play a role in creating peptides for presentation by MHC class I proteins. Studies of gene-deficient mice, in which each immunoproteasomal subunit was affected, have demonstrated that dysfunction of immunoproteasomes leads to immunodeficiency, i.e.
openaire +2 more sources
, 2016 Cardiomyocyte death as a result of viral infection is an excellent model for dissecting the inflammatory stress response that occurs in heart tissue. We reported earlier that a specific proteasome isoform, the immunoproteasome, prevents exacerbation of ...
Antje Voigt +21 more
core +1 more source
MoleculesThe immunoproteasome (iCP) is an isoform of the 20S proteasome that is expressed in response to cellular stress or inflammatory stimuli. The primary role of the iCP is to hydrolyze proteins into peptides that can be loaded into the MHC-I complex.
Francesca Mancuso +5 more
doaj +1 more source
Non-covalent immunoproteasome inhibitors induce cell cycle arrest in multiple myeloma MM.1R cells
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Proteasome inhibition is a promising strategy for the treatment of multiple myeloma; unfortunately, this disease is often associated with an increasing chemoresistance.
Roberta Ettari +9 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells [PDF]
, 2016 © 2016 Elsevier B.V. and Société française de biochimie et biologie Moléculaire (SFBBM). All rights reserved.The pathogenesis of autoimmune and neurodegenerative diseases involves overexpression of inducible subunits of the immunoproteasome. However, the
Belogurov A. +8 more
core
Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells
, 2020 © 2016 Elsevier B.V. and Société française de biochimie et biologie Moléculaire (SFBBM). All rights reserved.The pathogenesis of autoimmune and neurodegenerative diseases involves overexpression of inducible subunits of the immunoproteasome. However, the
Belogurov A. +8 more
core
Heatmap illustration of immunoproteasome genes.
, 2013 (A) The heatmap shows immunoproteasome genes (protein ubiquitinitation pathway) that were differentially expressed in monocytes from IFNb responders and non-responders. Gene names and Affymetrix probe sets are shown on the right part of the figure. Green
Marta F. Bustamante (208447) +4 more
core +1 more source
CGRPβ suppresses the pathogenesis of ulcerative colitis via the immunoproteasome
Scientific ReportsVarious factors have been implicated in the pathogenesis of ulcerative colitis (UC), with immune system failure being the most important one. Calcitonin gene-related peptide (CGRP), a neuropeptide with two isoforms, CGRPα and CGRPβ, has been reported to ...
Tatsuya Shibao +7 more
doaj +1 more source