CD8+ T-cell responses in vaccination: Reconsidering targets and function in the context of chronic antigen stimulation [PDF]
, 2018 Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines.
Cosma, Gabriela L., Eisenlohr, Laurence
core +2 more sources
Effectiveness and Mechanism of Cryoablation in the Treatment of Oral Mucosal Melanoma
Cancer Medicine, Volume 15, Issue 2, February 2026.ABSTRACT Objectives To assess the effectiveness and safety of cryoablation for oral mucosal melanoma (OMM) and explore its underlying mechanisms to provide insights for precision treatment of OMM. Materials and Methods Patients diagnosed with OMM were divided into a cryoablation group and a noncryoablation therapy group.
Zhu You +8 more
wiley +1 more source
Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction [PDF]
, 2023 Min‐Ji Kim +11 more
openalex +1 more source
Advanced Science, Volume 13, Issue 5, 27 January 2026.Extracellular vesicle (EV)‐packaged CDC37 are released from TMBhiCTLlo breast cancer cells with high CDC37 expression, and internalized into endo/phagosomes of dendritic cells (DCs). Within these compartments, CDC37 locked HSP90–antigen complex, preventing antigen release into the cytosol.
Ruxin Wang +10 more
wiley +1 more source
Identifying characteristics of frailty in female mice using a phenotype assessment tool [PDF]
, 2019 Preclinical studies are important in identifying the underlying mechanisms contributing to frailty. Frailty studies have mainly focused on male rodents with little directed at female rodents.
Baumann, Cory W. +2 more
core +1 more source
Cancer Nexus, Volume 2, Issue 1, January 2026.Mechanisms of resistance to cancer immunotherapy from a host–tumor interaction perspective. The central tumor cell is protected by multiple resistance mechanisms, including genetic mutations, epigenetic modifications, and metabolic alterations. The immunosuppressive tumor microenvironment features myeloid‐derived suppressor cells (MDSCs), regulatory T ...
Mohammed Elmujtba Adam Essa +2 more
wiley +1 more source
Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer’s Disease [PDF]
, 2021 Min Jae Lee +11 more
openalex +1 more source
Piplartine as an Innovative Natural Product With Dual Antiparasitic and Immunomodulatory Actions
Journal of Immunology Research, Volume 2026, Issue 1, 2026.Neglected tropical diseases (NTDs) remain a major global health burden, disproportionately affecting low‐ and middle‐income regions and demanding innovative therapeutic strategies. This review summarizes current evidence on piplartine (piperlongumine), a naturally occurring amide from Piper species with broad antiparasitic and immunomodulatory ...
Lucas Fukui-Silva +4 more
wiley +1 more source
Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis [PDF]
, 2017 Osteopontin is a pleiotropic cytokine that is involved in several diseases including multiple sclerosis. Secreted osteopontin is cleaved by few known proteases, modulating its pro-inflammatory activities.
Boneschi, Filippo Martinelli +14 more
core +1 more source
O15‐3: The immunoproteasome as a potential therapeutic target in cisplatin‐resistant small cell and non‐small cell lung cancer [PDF]
, 2021 openalex +1 more source