Results 101 to 110 of about 5,747 (197)

The Antiviral Immune Response in Mice Devoid of Immunoproteasome Activity

, 2011
The replacement of the catalytically active proteasome subunits β1, β2, and β5 by the immunoproteasome subunits low molecular mass polypeptide (LMP) 2 (β1i), multicatalytic endopeptidase complex-like–1 (MECL-1) (β2i), and LMP7 (β5i) is required for the ...
Ulrike Beck, Christopher J. Kirk, Michael Basler, Marcus Groettrup   +3 more
core   +1 more source

Non-covalent immunoproteasome inhibitors induce cell cycle arrest in multiple myeloma MM.1R cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Proteasome inhibition is a promising strategy for the treatment of multiple myeloma; unfortunately, this disease is often associated with an increasing chemoresistance.
Roberta Ettari, Giovanni Pallio, Gabriele Pizzino, Natasha Irrera, Maria Zappalà, Santina Maiorana, Carla Di Chio, Domenica Altavilla, Francesco Squadrito, Alessandra Bitto   +9 more
doaj   +1 more source

Immunoproteasome Deficiency Impairs Microglial Clearance and Worsens Tau and Amyloid Pathology

Immunoproteasome induction is prominent in Alzheimers disease (AD), but whether it protects proteostasis or amplifies neuroinflammation remains unresolved.
Helen Y Figueroa, Mayank Kumar, Shan Jiang, Malavika Srikanth, Timothy Lantin, Steven M Wellman, Mu Yang, Daniella E Lorman, Avery M Runyan, Natura Myeku, Shrita Sarkar, Qi Wang, Eric Sydney   +12 more
core   +1 more source

Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages.

, 2016
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes involved in shaping adaptive immune responses, but their role in innate immune ...
Yu, Y., Meiners, S., M Irmler, Eickelberg, O., Y Yu, Y Wu, O Vosyka, Beckers, J., Vosyka, O., Baumann, T., Wu, Y., S Chen, Overkleeft, H.S., T Baumann, J Beckers, Stöger, T., Irmler, M., T Stoeger, Stoeger, T., Chen, S., O Eickelberg, H S Overkleeft, Kammerl, I.E., S Meiners, I E Kammerl   +24 more
core   +1 more source

Systematically exploring the immune and housekeeping roles of the immunoproteasome

, 2012
© 2012 Dr. Damien John ZankerA central role in infection-free immunity is the continual monitoring and surveillance for pathogens in the body. Every nucleated cell possesses the ability to display protein fragments (peptides) derived from the internal ...
Zanker, Damien John
core   +1 more source

Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells

, 2020
© 2016 Elsevier B.V. and Société française de biochimie et biologie Moléculaire (SFBBM). All rights reserved.The pathogenesis of autoimmune and neurodegenerative diseases involves overexpression of inducible subunits of the immunoproteasome. However, the
Belogurov A., Chernolovskaya E., Ven'yaminova A., Kuzina E., Meschaninova M., Zenkova M., Gvozdeva O., Gabibov A., Vlassov V.   +8 more
core  

Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells [PDF]

, 2016
© 2016 Elsevier B.V. and Société française de biochimie et biologie Moléculaire (SFBBM). All rights reserved.The pathogenesis of autoimmune and neurodegenerative diseases involves overexpression of inducible subunits of the immunoproteasome. However, the
Belogurov A., Chernolovskaya E., Ven'yaminova A., Kuzina E., Meschaninova M., Zenkova M., Gvozdeva O., Gabibov A., Vlassov V.   +8 more
core  

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

CGRPβ suppresses the pathogenesis of ulcerative colitis via the immunoproteasome

Scientific Reports
Various factors have been implicated in the pathogenesis of ulcerative colitis (UC), with immune system failure being the most important one. Calcitonin gene-related peptide (CGRP), a neuropeptide with two isoforms, CGRPα and CGRPβ, has been reported to ...
Tatsuya Shibao, Hiroaki Hase, Kodai Mizokami, Atsushi Usui, Kaori Kitae, Yuko Ueda, Kentaro Jingushi, Kazutake Tsujikawa   +7 more
doaj   +1 more source

Epoxyketone-Based Immunoproteasome Inhibitors [PDF]

, 2010
An efficient new route for the preparation of dihydroeponemycin, an active eponemycin derivative, is provided, which includes the synthesis of the intermediate compound, a hydroxymethyl-substituted enone.
Kim, Kyung Bo, Ho, Yik Khuan
core