Results 81 to 90 of about 5,882 (203)
Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 9, September 2026.Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao +10 more
wiley +1 more source
Immunoproteasome expression is induced in mesial temporal lobe epilepsy.
, 2011 Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of ...
BELLAVISTA, ELENA +15 more
core +1 more source
MedComm – Oncology, Volume 5, Issue 3, September 2026.The up‐to‐date clinical progress of immune checkpoint inhibitor (ICI) therapy in solid tumors, specifically the combinational regimens between ICIs and other treatment strategies, the mechanisms underlying primary and acquired resistance, and mechanism‐matched strategies to improve clinical outcomes are synthesized in this review.
Qiongyu Zhang, Zhi Qin, Caijuan Guo
wiley +1 more source
Immunoproteasome β5i‐Selective Dipeptidomimetic Inhibitors [PDF]
ChemMedChem, 2016 AbstractN,C‐capped dipeptides belong to a class of noncovalent proteasome inhibitors. Herein we report that the insertion of a β‐amino acid into N,C‐capped dipeptides markedly decreases their inhibitory potency against human constitutive proteasome β5c, while maintaining potent inhibitory activity against human immunoproteasome β5i, thereby achieving ...
Pradeep K, Singh +5 more
openaire +2 more sources
Acta Physiologica, Volume 242, Issue 9, September 2026.ABSTRACT In the central nervous system (CNS), the tissue microenvironment is continuously monitored and regulated to secure the unobstructed function of neurons and of their networks. This is a key function of the neurovascular niche (NVN), which is the interface between the cells of the nervous tissue and the cells and the content of blood vessels. It
Ilias Kazanis +4 more
wiley +1 more source
The Immunoproteasome in oxidative stress, aging, and disease [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2016 The Immunoproteasome has traditionally been viewed primarily for its role in peptide production for antigen presentation by the major histocompatibility complex, which is critical for immunity. However, recent research has shown that the Immunoproteasome is also very important for the clearance of oxidatively damaged proteins in homeostasis, and ...
Helen K, Johnston-Carey +2 more
openaire +2 more sources
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, Volume 293, Issue 18, Page 5645-5663, September 2026.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
Stimulating proteasomal degradation in human proteinopathies
The FEBS Journal, Volume 293, Issue 18, Page 5514-5540, September 2026.The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch +2 more
wiley +1 more source
The immunoproteasome in antigen processing and other immunological functions
, 2013 Treatment of cells with interferon-g leads to the replacement of the constitutive catalytic proteasome subunits b1, b2, and b5 by the inducible subunits LMP2 (b1i), MECL-1 (b2i), and LMP7 (b5i), respectively, building the so-called immunoproteasome.
Kirk, Christopher J. +5 more
core +1 more source
Discovery of Immunoproteasome Inhibitors Using Large-Scale Covalent Virtual Screening
, 2019 Large-scale virtual screening of boronic acid derivatives was performed to identify nonpeptidic covalent inhibitors of the β5i subunit of the immunoproteasome.
Proj, Matic +17 more
core +2 more sources