Results 81 to 90 of about 4,214 (170)

Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells.

PLoS ONE, 2013
Autoimmune destruction of insulin producing pancreatic β-cells is the hallmark of type I diabetes. One of the key molecules implicated in the disease onset is the immunoproteasome, a protease with multiple proteolytic sites that collaborates with the ...
Wieke Freudenburg, Madhav Gautam, Pradipta Chakraborty, Jared James, Jennifer Richards, Alison S Salvatori, Aaron Baldwin, Jill Schriewer, R Mark L Buller, John A Corbett, Dorota Skowyra   +10 more
doaj   +1 more source

Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits.

PLoS Biology
Defective autophagy is linked to proinflammatory diseases. However, the mechanisms by which autophagy limits inflammation remain elusive. Here, we found that the pan-FGFR inhibitor LY2874455 efficiently activated autophagy and suppressed expression of ...
Jiao Zhou, Chunxia Li, Meng Lu, Gaoyue Jiang, Shanze Chen, Huihui Li, Kefeng Lu   +6 more
doaj   +1 more source

Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

EBioMedicine, 2018
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders.
Scott Ugras, Malcolm J. Daniels, Hossein Fazelinia, Neal S. Gould, Anastasia K. Yocum, Kelvin C. Luk, Esteban Luna, Hua Ding, Chris McKennan, Steven Seeholzer, Dan Martinez, Perry Evans, Daniel Brown, John E. Duda, Harry Ischiropoulos   +14 more
doaj   +1 more source

Recent Advances in the Development of Immunoproteasome Inhibitors as Anti-Cancer Agents: The Past 5 Years

Molecules
The immunoproteasome (iCP) is an isoform of the 20S proteasome that is expressed in response to cellular stress or inflammatory stimuli. The primary role of the iCP is to hydrolyze proteins into peptides that can be loaded into the MHC-I complex.
Francesca Mancuso, Carla Di Chio, Francesca Di Matteo, Gerardina Smaldone, Nunzio Iraci, Salvatore Vincenzo Giofrè   +5 more
doaj   +1 more source

Immunoproteasomes [PDF]

, 2012
Deborah A. Ferrington, Dale S. Gregerson
openaire   +2 more sources

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Non-covalent immunoproteasome inhibitors induce cell cycle arrest in multiple myeloma MM.1R cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Proteasome inhibition is a promising strategy for the treatment of multiple myeloma; unfortunately, this disease is often associated with an increasing chemoresistance.
Roberta Ettari, Giovanni Pallio, Gabriele Pizzino, Natasha Irrera, Maria Zappalà, Santina Maiorana, Carla Di Chio, Domenica Altavilla, Francesco Squadrito, Alessandra Bitto   +9 more
doaj   +1 more source

CGRPβ suppresses the pathogenesis of ulcerative colitis via the immunoproteasome

Scientific Reports
Various factors have been implicated in the pathogenesis of ulcerative colitis (UC), with immune system failure being the most important one. Calcitonin gene-related peptide (CGRP), a neuropeptide with two isoforms, CGRPα and CGRPβ, has been reported to ...
Tatsuya Shibao, Hiroaki Hase, Kodai Mizokami, Atsushi Usui, Kaori Kitae, Yuko Ueda, Kentaro Jingushi, Kazutake Tsujikawa   +7 more
doaj   +1 more source

Dominant-negative PSMB10 disrupts immunoproteasome assembly and leads to transient T lymphopenia. [PDF]

J Hum Immun
Ghosh S, Wang Y, Schultheiss C, Borkhardt A, Dafun AS, Knipp L, Marwitz S, Ehl S, Soulard C, Haddad E, Dey D, Evans G, Golwala ZM, Bennstein SB, Laws HJ, Rohlfs M, Magg T, Binder M, Kreins AY, Bousquet MP, Marcoux J, Klein C, Conn GL, Meiners S, Hauck F.   +24 more
europepmc   +1 more source

Monoallelic PSMB8 variants cause PRAAS with immunodeficiency through impaired immunoproteasome assembly. [PDF]

Am J Hum Genet
Wijngaard R, van der Made CI, Kalkan Uçar S, Ramakrishnan G, Wang M, Brand J, Rosenfeld JA, Vogel TP, Nicholas SK, Weisz-Hubshman M, Undiagnosed Diseases Network, van Karnebeek CDM, Allenspach EJ, Gardiner TE, Perera Kimmantudawage S, Stark Z, Armstrong RK, Campbell J, Volpi S, Drago E, Gattorno M, Grossi A, Ceccherini I, Cabrera-Orefice A, Siebels B, Mair T, Schlüter H, Smeets RL, van Beek R, Goebel I, Küchler K, Gersting SW, Hoischen A, Vissers LELM, Wevers RA, Meyer-Schwesinger C, Wortmann SB, Oud MM, Guerrero-Castillo S.   +38 more
europepmc   +1 more source