Results 81 to 90 of about 5,747 (197)

Immunoproteasome β5i‐Selective Dipeptidomimetic Inhibitors [PDF]

ChemMedChem, 2016
AbstractN,C‐capped dipeptides belong to a class of noncovalent proteasome inhibitors. Herein we report that the insertion of a β‐amino acid into N,C‐capped dipeptides markedly decreases their inhibitory potency against human constitutive proteasome β5c, while maintaining potent inhibitory activity against human immunoproteasome β5i, thereby achieving ...
Pradeep K, Singh, Hao, Fan, Xiuju, Jiang, Lei, Shi, Carl F, Nathan, Gang, Lin   +5 more
openaire   +2 more sources

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

The Immunoproteasome in oxidative stress, aging, and disease [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2016
The Immunoproteasome has traditionally been viewed primarily for its role in peptide production for antigen presentation by the major histocompatibility complex, which is critical for immunity. However, recent research has shown that the Immunoproteasome is also very important for the clearance of oxidatively damaged proteins in homeostasis, and ...
Helen K, Johnston-Carey, Laura C D, Pomatto, Kelvin J A, Davies   +2 more
openaire   +2 more sources

Single‐Cell RNA Sequencing Revealed the Role of Interferon‐Gamma Related Genes in Primary Sjögren's Syndrome

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder. Dysregulated interferon‐gamma (IFN‐γ) signalling is implicated in pSS pathogenesis, yet the underlying mechanisms remain elusive. This study aimed to identify key IFN‐γ‐associated diagnostic genes and delineate their roles in immune dysregulation using peripheral blood ...
Lei Shi, Tian‐chi Wei, Jing Zhang
wiley   +1 more source

Mass spectrometry proteomics for studying mitostasis

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Maintaining mitochondrial integrity and function is fundamental to cellular homeostasis. Cells rely on coordinated protein quality control (QC) systems—including intricate chaperone‐protease networks, the ubiquitin‐proteasome system, and cytosolic surveillance pathways—that together form a dynamic, cell‐wide mitostasis network governing the ...
Lakshita Sharma, Sristi Chakroborty, Hirak Das, Silke Oeljeklaus, Julian Bender, Bettina Warscheid   +5 more
wiley   +1 more source

Immunoproteasome in cancer and neuropathologies: a new therapeutic target?

, 2013
Immunoproteasome is an emerging biological target that constitutes a key element not only in antigen presentation but also in T cell and cytokine regulation as well as cellular homeostasis.
BELLAVISTA, ELENA, PARENTI, MARCO DANIELE, MISHTO, MICHELE, FRANCESCHI, CLAUDIO, MARTUCCI, MORENA, SALVIOLI, STEFANO, DEL RIO, ALBERTO, SANTORO, AURELIA, BARUZZI, AGOSTINO, ANDREOLI, FEDERICO, CAPRI, MIRIAM   +10 more
core   +1 more source

Identifying novel roles for the immunoproteasome in the retina.

, 2010
University of Minnesota Ph.D. dissertation. October 2010. Major: Biochemistry, Molecular Bio, and Biophysics. Advisors: Dr. Deborah A. Ferrington, Ph.D., 1 computer file (PDF); xii, 204 pages, appendix p. 200-204.Immunoproteasome is a proteasome sub-type
Hussong, Stacy Ann
core  

Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema Via Activating NRF1/2‐P62 Axis and Suppressing IRF4 Transcription

Advanced Science
Chronic obstructive pulmonary disease (COPD) stands as the prevailing chronic airway ailment, characterized by chronic bronchitis and emphysema. Current medications fall short in treatment of these diseases, underscoring the urgent need for effective ...
Bingxin Guo, Xing Shi, Qiong Jiang, Yuanwei Pan, Yuqiong Yang, Yuanyuan Liu, Shuyu Chen, Wenjiao Zhu, Laibin Ren, Ruifang Liang, Xue Chen, Haizhao Xu, Laiyou Wei, Yongjian Lin, Jinyong Wang, Chen Qiu, Haibo Zhou, Lang Rao, Lingwei Wang, Rongchang Chen, Shanze Chen   +20 more
doaj   +1 more source

Subversion of immunoproteasome subunit expression in dengue virus serotype 2-infected HepG2 cells

Revista da Sociedade Brasileira de Medicina Tropical
: INTRODUCTION: Infection with all serotypes of dengue virus (DV) results in augmented antigen presentation by MHC class I molecules. However, the upregulation of immunoproteasome subunits only results from infection with two serotypes. This study aims
Chye Sheng Gan, Pei Jean Lim, Muhammad Fazril Mohamad Razif, Rohana Yusof, Shatrah Othman   +4 more
doaj   +1 more source

Immune and non-immune functions of the immunoproteasome

Frontiers in Bioscience, 2012
The biological importance of the ubiquitin-proteasome system in the control of myriad cellular processes has been well-recognized; however, the pathophysiological significance of the immunoproteasome, the inducible form of the proteasome, has not been well-comprehended until lately.
Arkhjamil, Angeles, Gabriel, Fung, Honglin, Luo   +2 more
openaire   +2 more sources