Results 61 to 70 of about 8,916 (246)

Blood Immunoproteasome Activity Is Regulated by Sex, Age and in Chronic Inflammatory Diseases: A First Population-Based Study

Cells, 2021
Dysfunction of the immunoproteasome has been implicated in cardiovascular and pulmonary diseases. Its potential as a biomarker for predicting disease stages, however, has not been investigated so far and population-based analyses on the impact of sex and
Ilona Elisabeth Kammerl, Claudia Flexeder, Stefan Karrasch, Barbara Thorand, Margit Heier, Annette Peters, Holger Schulz, Silke Meiners   +7 more
doaj   +1 more source

Proteostasis and ageing: insights from long-lived mutant mice [PDF]

, 2017
The global increase in life expectancy is creating significant medical, social and economic challenges to current and future generations. Consequently, there is a need to identify the fundamental mechanisms underlying the ageing process.
Page, Melissa M., Sands, William A., Selman, Colin   +2 more
core   +1 more source

Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

Nature Communications, 2017
Immunoproteasome selective inhibitors might lead to less toxic drugs for treatment of multiple myeloma and graft rejection. Here, the authors develop immunoproteasome specific asparagine-ethylenediamine (AsnEDA)-based inhibitory compounds, demonstrate ...
Ruda de Luna Almeida Santos, Lin Bai, Pradeep K. Singh, Naoka Murakami, Hao Fan, Wenhu Zhan, Yingrong Zhu, Xiuju Jiang, Kaiming Zhang, Jean Pierre Assker, Carl F. Nathan, Huilin Li, Jamil Azzi, Gang Lin   +13 more
doaj   +1 more source

Impact of Leishmania donovani infection on the HLA I self peptide repertoire of human macrophages [PDF]

, 2018
Macrophages are specialized antigen-presenting cells that process and present self-antigens for induction of tolerance, and foreign antigens to initiate T cell-mediated immunity.
Jarmalavicius, Saulius, Nyambura, Lydon Wainaina, Walden, Peter   +2 more
core   +1 more source

Neuronal Induction of the Immunoproteasome in Huntington's Disease [PDF]

The Journal of Neuroscience, 2003
Huntington's disease (HD) inclusions are stained with anti-ubiquitin and anti-proteasome antibodies. This, together with proteasome activity studies on transfected cells, suggest that an impairment of the ubiquitin-proteasome system (UPS) may be key in HD pathogenesis.
Díaz-Hernández, Miguel, Hernández, Félix, Martín-Aparicio, Ester, Gómez-Ramos, Pilar, Morán, María A., Castaño, José G., Ferrer, Isidro (Ferrer Abizanda), Avila, Jesús, Lucas, José J.   +8 more
openaire   +4 more sources

Enhanced Expression of Interferon-γ-Induced Antigen-Processing Machinery Components in a Spontaneously Occurring Cancer [PDF]

, 2007
In human tumors, changes in the surface expression and/or function of major histocompatibility complex (MHC) class I antigens are frequently found and may provide malignant cells with a mechanism to escape control of the immune system. This altered human
Cerruti, Fulvia, Martano, Marina, Petterino, Claudio, Bollo, Enrico, Morello, Emanuela, Bruno, Renato, Buracco, Paolo, Cascio, Paolo   +7 more
core   +2 more sources

The histological and immunohistochemical features of the skin lesions in CANDLE syndrome [PDF]

, 2015
Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a newly characterized autoinflammatory disorder, caused by mutations in PSMB8.
Colmenero, Isabel, Goldbach-Mansky, Raphaela, Kutzner, Heinz, Lee, Chyi-Chia Richard, Paller, Amy S., Ramot, Yuval, Requena, Luis, Torrelo, Antonio J., Vera, Ángel, Zlotogorski, Abraham   +9 more
core   +2 more sources

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, EarlyView.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

The Immunoproteasome in oxidative stress, aging, and disease [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2016
The Immunoproteasome has traditionally been viewed primarily for its role in peptide production for antigen presentation by the major histocompatibility complex, which is critical for immunity. However, recent research has shown that the Immunoproteasome is also very important for the clearance of oxidatively damaged proteins in homeostasis, and ...
Helen K, Johnston-Carey, Laura C D, Pomatto, Kelvin J A, Davies   +2 more
openaire   +2 more sources

Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells [PDF]

, 2016
Background Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased approach to identify pathways activated in bronchoalveolar lavage (BAL ...
A Malur, A Subramanian, AI Saeed, B Guillaume, BM Bolstad, D Merico, D Szklarczyk, D Valeyre, DA Ferrington, E Kruger, ED Crouser, EE Schadt, F Larousserie, G Kar, G Nalepa, GW Hunninghake, J Grunewald, J Wahlstrom, J Wang, JD Storey, JE Snyder-Cappione, K Fellenberg, K Osolnik, LH Hartwell, LL Koth, LS Newman, M Ashburner, M Facco, M Karin, M Vidal, MA Judson, MA Judson, MA Kayala, MC Iannuzzi, MJ Edelmann, MS Cline, P Korosec, R Su, R Su, S Ringkowski, SE Calvano, SU Sixt, TD Schmittgen, Y Ben-Neriah   +43 more
core   +3 more sources