Results 61 to 70 of about 4,214 (170)

Type I and II Interferon Signalling Characterizes the Transcriptional Landscape of Sweet Syndrome

Experimental Dermatology, Volume 35, Issue 7, July 2026.
ABSTRACT Sweet syndrome (SS) is an autoinflammatory neutrophilic dermatosis characterized by abrupt‐onset inflammatory skin lesions and systemic symptoms, yet its molecular pathogenesis remains incompletely defined. To delineate disease‐specific inflammatory programmes, we performed NanoString‐based transcriptomic analysis of SS skin lesions and ...
Laura Calabrese, Chiara Moltrasio, Maurizio Romagnuolo, Pia‐Charlotte Stadler, Zeno Fiocco, Matthias Neulinger‐Muñoz, Rui Aoki, Martina D'Onghia, Pietro Rubegni, Katrin Kerl, Takashi K. Satoh, Angelo V. Marzano, Lars E. French   +12 more
wiley   +1 more source

The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi. [PDF]

PLoS Pathogens, 2016
The β1i, β2i and β5i immunoproteasome subunits have an important role in defining the repertoire of MHC class I-restricted epitopes. However, the impact of combined deficiency of the three immunoproteasome subunits in the development of protective ...
Jonatan Ersching, José R Vasconcelos, Camila P Ferreira, Braulia C Caetano, Alexandre V Machado, Oscar Bruna-Romero, Monique A Baron, Ludmila R P Ferreira, Edécio Cunha-Neto, Kenneth L Rock, Ricardo T Gazzinelli, Maurício M Rodrigues   +11 more
doaj   +1 more source

The Immunoproteasome Cleans up after Inflammation [PDF]

Cell, 2010
Immune cells and cells activated by the inflammatory cytokine interferon express variant proteasomes called immunoproteasomes that are characterized by unique catalytic subunits. Seifert et al. (2010) now show in mouse models of inflammatory disease that immunoproteasomes help prevent the accumulation of harmful protein aggregates.
van Deventer, Sjoerd, Neefjes, Jacques
openaire   +2 more sources

The Functional and Mechanistic Roles of Immunoproteasome Subunits in Cancer

Cells, 2021
Cell-mediated immunity is driven by antigenic peptide presentation on major histocompatibility complex (MHC) molecules. Specialized proteasome complexes called immunoproteasomes process viral, bacterial, and tumor antigens for presentation on MHC class I
Satyendra Chandra Tripathi, Disha Vedpathak, Edwin Justin Ostrin   +2 more
doaj   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, Volume 2, Issue 2, Page 343-370, June 2026.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation

Journal of Neuroinflammation
Objective Obesity represents a significant global health challenge characterized by chronic low-grade inflammation and metabolic dysregulation. The hypothalamus, a key regulator of energy homeostasis, is particularly susceptible to obesity’s deleterious ...
Nicolás Albornoz, Javiera Álvarez-Indo, Adely de la Peña, Eloisa Arias-Muñoz, Alanis Coca, Fabián Segovia-Miranda, Bredford Kerr, Mauricio Budini, Alfredo Criollo, María A. García-Robles, Eugenia Morselli, Andrea Soza, Patricia V. Burgos   +12 more
doaj   +1 more source

A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus.

PLoS ONE, 2011
Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates and immunocompromised adults.
Sarah Hutchinson, Stuart Sims, Geraldine O'Hara, Jon Silk, Uzi Gileadi, Vincenzo Cerundolo, Paul Klenerman   +6 more
doaj   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, Volume 183, Issue 12, Page 3355-3376, June 2026.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Stable β2‐Microglobulin–HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer‐Associated Epitopes

European Journal of Immunology, Volume 56, Issue 5, May 2026.
We investigated differences in peptide repertoire when β2‐microglobulin is fused to the HLA‐I heavy chain. We observed: (1) that immunopeptidomes changed in this condition, (2) an overall increased median IC50 of the entire peptide repertoire, and (3) a reduced presentation of cancer‐specific epitopes with a strong predicted binding affinity for HLA‐I.
Ana Barajas Molina, Yehor Horokhovskyi, Nicole Acuti, Yee Kien Chong, Meghna Phanichkrivalkosil, Sophie Siddons, Hassnae Afrache, Megan Maloney, Wai Tuck Soh, Tom Hofland, Callum Hall, Henning Urlaub, George Kassiotis, Juliane Liepe, Michele Mishto   +14 more
wiley   +1 more source